Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

23239

Name

PHLPP1

Synonymous

PHLPP|PLEKHE1|SCOP;PH domain and leucine rich repeat protein phosphatase 1;PHLPP1;PH domain and leucine rich repeat protein phosphatase 1

Definition

PH domain leucine-rich repeat-containing protein phosphatase 1|PH domain-containing family E member 1|SCN circadian oscillatory protein|pleckstrin homology domain containing, family E (with leucine rich repeats) member 1|suprachiasmatic nucleus circadian

Position

18q21.33

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors

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Regulation From TransFac database

phlpp1(h) + PKCbetaII(m.s.) <==> phlpp1(h):PKCbetaII(m.s.) (binding)
PHLPP(h) --> phlpp1(h) (expression).
PKCbetaII(m.s.){pT641}{pS660} --phlpp1(h)--> PKCbetaII(m.s.) + 2 p (dephosphorylation)
PKCbetaII(m.s.){p} --phlpp1(h)--> PKCbetaII(m.s.) + p (dephosphorylation)
phlpp1(h) --> AKT-2(h){pS474} (increase of phosphorylation)
phlpp1(h) --> AKT-3(h){p} (increase of phosphorylation)
phlpp1(h) --/ PKCbeta(h) (decrease of abundance)
phlpp1(h) --/ PKCalpha(h) (decrease of abundance)
phlpp1(h) --/ PKCdelta(h) (decrease of abundance)
phlpp1(h) --/ PKCepsilon(h) (decrease of abundance)
PHLPP(h) --> phlpp1(h) (expression).
Abl(h) --/ phlpp1(h) (decrease of abundance)

Post Transcriptional Modification From dbPTM

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There is no record for PHLPP1

Methylation Profile From DiseaseMeth database

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Chromosome

Location

Source

chr18

Promoter: 58532214 - 58534214GSE27584

chr18

Promoter: 58532214 - 58534214Agilent_014791


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