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General information | Expression | Regulation | Mutation | Interaction |
Basic Information |
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Gene ID | 23239 |
Name | PHLPP1 |
Synonymous | PHLPP|PLEKHE1|SCOP;PH domain and leucine rich repeat protein phosphatase 1;PHLPP1;PH domain and leucine rich repeat protein phosphatase 1 |
Definition | PH domain leucine-rich repeat-containing protein phosphatase 1|PH domain-containing family E member 1|SCN circadian oscillatory protein|pleckstrin homology domain containing, family E (with leucine rich repeats) member 1|suprachiasmatic nucleus circadian |
Position | 18q21.33 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
Regulation From TransFac database |
phlpp1(h) + PKCbetaII(m.s.) <==> phlpp1(h):PKCbetaII(m.s.) (binding) | PHLPP(h) --> phlpp1(h) (expression). | PKCbetaII(m.s.){pT641}{pS660} --phlpp1(h)--> PKCbetaII(m.s.) + 2 p (dephosphorylation) | PKCbetaII(m.s.){p} --phlpp1(h)--> PKCbetaII(m.s.) + p (dephosphorylation) | phlpp1(h) --> AKT-2(h){pS474} (increase of phosphorylation) | phlpp1(h) --> AKT-3(h){p} (increase of phosphorylation) | phlpp1(h) --/ PKCbeta(h) (decrease of abundance) | phlpp1(h) --/ PKCalpha(h) (decrease of abundance) | phlpp1(h) --/ PKCdelta(h) (decrease of abundance) | phlpp1(h) --/ PKCepsilon(h) (decrease of abundance) | PHLPP(h) --> phlpp1(h) (expression). | Abl(h) --/ phlpp1(h) (decrease of abundance) |
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Post Transcriptional Modification From dbPTM | | Top | |
There is no record for PHLPP1 |
Methylation Profile From DiseaseMeth database | | Top | |
Chromosome |
Location |
Source |
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chr18 |
Promoter: 58532214 - 58534214 | GSE27584 |
chr18 |
Promoter: 58532214 - 58534214 | Agilent_014791 |
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