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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 23365 |
Name | ARHGEF12 |
Synonym | LARG|PRO2792;Rho guanine nucleotide exchange factor (GEF) 12;ARHGEF12;Rho guanine nucleotide exchange factor (GEF) 12 |
Definition | leukemia-associated RhoGEF|leukemia-associated rho guanine nucleotide exchange factor|rho guanine nucleotide exchange factor 12 |
Position | 11q23.3 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 1 PubMed records as below. |
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Evidence Status |
Description |
potential | LARG at chromosome 11q23 has functional characteristics of a tumor suppressor in human breast and colorectal cancer. |
| More detail of all 1 literatures about ARHGEF12 | |
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Pathways and Diseases |
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Pathway | Vascular smooth muscle contraction;KEGG PATHWAY;hsa04270 |
Pathway | G alpha (12/13) signalling events;PID Reactome;500437 |
Pathway | Regulation of RhoA activity;PID Curated;200050 |
Pathway | Signaling by Rho GTPases;Reactome;REACT:11044 |
Pathway | Signaling by GPCR;Reactome;REACT:14797 |
Pathway | Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810 |
Pathway | Axon guidance;KEGG PATHWAY;hsa04360 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Disease | Leukemia, acute myeloid;OMIM |
Disease | METABOLIC;GAD |
Disease | glucose insulin;GAD |
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External Links |
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Links to Entrez Gene | 23365 |
Links to all GeneRIF Items | 23365 |
Links to iHOP | 23365 |
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Sequence Information |
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Nucleotide Sequence |
>23365 : length: 4578 atgagtggcacacagtctactatcaccgacaggtttcccctcaaaaaacctataaggcat ggaagtattttgaaccgagagtcaccaacagataagaagcagaaagttgagcgcattgca tcacatgattttgaccccacaggtcttgttcagcgttgcgtaatcatccagaaagatgac aatggatttgggctgacggtcagtggagacaatccagtcttcgtacagtctgtcaaagaa gatggagcagccatgcgggctggagtacagacaggtgatcgaatcatcaaggtgaatgga actctggtgactcattcaaatcatctggaggtggtgaagctaatcaaatctggttcctat gtagctctcactgttcagggacgcccacctgggtcgccccagattccacttgccgactct gaagtagagccgtcagtcattggacatatgtctcccatcatgacatctcctcattcacct ggagcatctgggaatatggagagaatcactagtcctgtgctcatgggggaggaaaacaat gtggttcataaccagaaagtagaaattctgagaaaaatgttacagaaagaacaggaacgg ctacagttattgcaggaagattacaaccgaacacctgcccaaagattgctaaaagagatc caagaggccaagaaacacattcctcagctgcaagagcagttatccaaagccacaggctct gctcaggatggagctgtagttacaccctccagacctttaggggacaccctaacagtcagt gaggcagaaacagatcctggagatgtactgggcaggactgactgtagcagtggagatgct tctcggcccagtagtgacaatgcagatagtcccaagagtggcccaaaagagagaatttat ctagaggaaaacccagagaaaagtgaaacaattcaggacactgacactcaatcacttgtc ggaagtccctcaacccgtatagcacctcatattattggagcagaagatgatgattttggt actgaacatgaacagatcaatggacagtgcagctgtttccagagcattgaattactaaaa tctcgcccggctcatttggctgttttcttacaccatgtagtttcacaatttgaccctgcg actttgctctgttatctctattcagacctgtataaacataccaattccaaagaaactcgt cgcatcttccttgagtttcatcagttctttctagatcgatcagcacacctgaaagtttct gttcctgatgaaatgtctgcagatctagaaaagagaagacctgagctcattcctgaggat ctgcatcgccactatatccaaactatgcaagaaagagtccatccagaagttcaaaggcac ttagaagattttcggcagaaacgtagtatgggactgaccttggctgaaagcgagctgact aaacttgatgcagagcgagacaaggaccgattgactttggagaaggagcggacatgtgca gaacagattgttgccaaaattgaagaagtattgatgactgctcaggctgtagaggaagat aagagctccaccatgcagtatgttattctcatgtatatgaagcatttgggagtaaaagtg aaagagcctcgaaatttggagcacaaacggggtcggattggatttcttcccaaaatcaag caaagtatgaagaaagataaagaaggggaagaaaaagggaagcgaagaggattccccagc atcctgggacccccacggagaccaagccgtcatgacaacagtgcaattggcagagccatg gaactacagaaggcgcgccaccctaagcacttatccacaccctcatctgtgagtcctgaa cctcaggactctgccaagttgcgccagagtgggttagcaaatgaaggaacagacgctgga tacctgcctgccaattccatgtcttctgtagcttcaggggcctctttttcccaggaagga gggaaagagaatgatacaggatcaaagcaagttggagaaacatcagcacctggagacacc ttagatggcacacctcgtactctcaatactgtctttgatttcccaccacctccattagac caagtgcaggaggaggaatgtgaagtagaaagggtgactgaacatgggacaccaaagccc tttcgaaagtttgacagtgtagcttttggagaaagtcaaagtgaggatgaacaatttgaa aatgacttagagacagatccacccaactggcagcagcttgttagtcgagaagtgttactg ggactaaaaccttgtgaaatcaaaagacaggaagtgattaatgaattgttctacactgaa agagctcatgttcgaacactgaaggttcttgatcaagtgttctatcagcgagtatccaga gaaggaattctgtcaccctcagagctacggaaaattttttcaaacttggaagatattctt caacttcatattggattgaatgaacaaatgaaggctgttcgaaagagaaatgagacctct gttatcgatcagattggggaagatttgctgacatggttcagcggaccaggagaggagaaa ttgaaacatgctgctgctaccttttgcagtaaccaacctttcgccctggaaatgatcaaa tctcgtcagaaaaaggattctcgatttcagacttttgtgcaagatgctgaaagtaatcca ctgtgtcgtcgtcttcaactgaaggatattattcccactcaaatgcaaaggcttactaag tacccacttctgttggataatattgccaaatacacagaatggccaacagaaagggagaag gtgaagaaagctgcagatcactgtcgtcagatcttaaattatgtaaatcaggctgtcaag gaggcagaaaacaagcagcgcctagaagattatcagcgtcgccttgatacctccagcctg aagttgtcagagtacccaaatgttgaagagctcaggaatttggatttaacaaaaaggaag atgattcatgaagggccattggtttggaaggtgaatagagataaaactattgatttatac acgttgctgctggaagacattcttgtattgttacaaaagcaggatgatagactggtttta aggtgtcatagtaagattctggcatctacagctgatagcaaacacacgtttagccctgtc attaagttgagtacagtgttggttcgacaagtggcaacagataacaaagctttattcgtc atttccatgtcagacaatggcgctcagatttatgaactggtggcacagacagtttctgaa aagactgtctggcaggacctaatctgtcggatggctgcatcagtgaaggagcaatccaca aagccaattccattaccacagtcaacacctggcgaaggagataatgatgaagaagatcct tcaaaattaaaagaggagcagcatggcatttcagtcactggtttgcagagtccagacaga gatttgggattagaatctaccttaatatcgtcaaaacctcagtctcattcactgagtacc tctgggaaatcagaggtacgtgatctgtttgtggctgagagacagtttgcaaaggaacaa catacagatgggacactaaaggaagttggagaagattatcaaatcgcaatcccagattca cacctgcctgtctcagaagaacggtgggcattggatgcactaagaaatttgggtttgttg aagcagttgctggtgcaacagctaggtttgactgagaagagcgttcaggaagactggcaa catttcccaagatacagaacagcctctcaggggccgcagacagacagtgtcatccagaac tctgaaaatattaaggcctatcattctggtgaaggacatatgccctttagaactggaact ggtgacattgcaacttgttacagtccacggacttcaactgaatcttttgctccacgggat tcagtgggactggcaccccaggatagccaggcaagtaacattttagtaatggaccacatg attatgaccccagagatgcctaccatggagccagaagggggtcttgatgacagtggagag cacttttttgatgcccgtgaagcacatagtgatgagaatccatcagaaggtgatggagca gttaacaaggaagagaaggatgttaatttacgcatctcaggaaactatttgatccttgat ggctatgacccagtgcaggagagttccacagatgaggaggttgcttcctcacttaccctg cagcccatgacaggcatccctgctgtggaatccacccaccagcagcaacattctcctcag aatactcactccgatggggcaatttcaccattcacccccgaatttctggtccagcagcgc tggggagctatggagtattcctgttttgagatccagagtccctcctcttgtgcagattca cagagccagatcatggagtacattcataagatagaggctgaccttgaacacttaaagaag gtggaggaaagttacaccattctttgccaaaggctggctggatcagccctcacagacaag cactcagataaaagttag |
Protein Sequence |
>23365 : length: 1525 MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTGLVQRCVIIQKDD NGFGLTVSGDNPVFVQSVKEDGAAMRAGVQTGDRIIKVNGTLVTHSNHLEVVKLIKSGSY VALTVQGRPPGSPQIPLADSEVEPSVIGHMSPIMTSPHSPGASGNMERITSPVLMGEENN VVHNQKVEILRKMLQKEQERLQLLQEDYNRTPAQRLLKEIQEAKKHIPQLQEQLSKATGS AQDGAVVTPSRPLGDTLTVSEAETDPGDVLGRTDCSSGDASRPSSDNADSPKSGPKERIY LEENPEKSETIQDTDTQSLVGSPSTRIAPHIIGAEDDDFGTEHEQINGQCSCFQSIELLK SRPAHLAVFLHHVVSQFDPATLLCYLYSDLYKHTNSKETRRIFLEFHQFFLDRSAHLKVS VPDEMSADLEKRRPELIPEDLHRHYIQTMQERVHPEVQRHLEDFRQKRSMGLTLAESELT KLDAERDKDRLTLEKERTCAEQIVAKIEEVLMTAQAVEEDKSSTMQYVILMYMKHLGVKV KEPRNLEHKRGRIGFLPKIKQSMKKDKEGEEKGKRRGFPSILGPPRRPSRHDNSAIGRAM ELQKARHPKHLSTPSSVSPEPQDSAKLRQSGLANEGTDAGYLPANSMSSVASGASFSQEG GKENDTGSKQVGETSAPGDTLDGTPRTLNTVFDFPPPPLDQVQEEECEVERVTEHGTPKP FRKFDSVAFGESQSEDEQFENDLETDPPNWQQLVSREVLLGLKPCEIKRQEVINELFYTE RAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQLHIGLNEQMKAVRKRNETS VIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNP LCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPTEREKVKKAADHCRQILNYVNQAVK EAENKQRLEDYQRRLDTSSLKLSEYPNVEELRNLDLTKRKMIHEGPLVWKVNRDKTIDLY TLLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVIKLSTVLVRQVATDNKALFV ISMSDNGAQIYELVAQTVSEKTVWQDLICRMAASVKEQSTKPIPLPQSTPGEGDNDEEDP SKLKEEQHGISVTGLQSPDRDLGLESTLISSKPQSHSLSTSGKSEVRDLFVAERQFAKEQ HTDGTLKEVGEDYQIAIPDSHLPVSEERWALDALRNLGLLKQLLVQQLGLTEKSVQEDWQ HFPRYRTASQGPQTDSVIQNSENIKAYHSGEGHMPFRTGTGDIATCYSPRTSTESFAPRD SVGLAPQDSQASNILVMDHMIMTPEMPTMEPEGGLDDSGEHFFDAREAHSDENPSEGDGA VNKEEKDVNLRISGNYLILDGYDPVQESSTDEEVASSLTLQPMTGIPAVESTHQQQHSPQ NTHSDGAISPFTPEFLVQQRWGAMEYSCFEIQSPSSCADSQSQIMEYIHKIEADLEHLKK VEESYTILCQRLAGSALTDKHSDKS |