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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 2444 |
Name | FRK |
Synonym | GTK|PTK5|RAK;fyn-related kinase;FRK;fyn-related kinase |
Definition | PTK5 protein tyrosine kinase 5|nuclear tyrosine protein kinase RAK|protein-tyrosine kinase 5|tyrosine-protein kinase FRK |
Position | 6q21-q22.3 |
Gene Type | protein-coding |
Source | Count: 2; Generif,UniProt |
Literature support | Count: 2 PubMed records as below. |
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Evidence Status |
Description |
reviewed | "Study searched for mutations in the FRK gene, a recently identified tumor suppressor gene, for the first time in NSCLC. Somatic FRK mutations were found at a very low frequency in NSCLCs." |
reviewed | Rak functions as a tumor suppressor by regulating PTEN protein stability and function in breast and bone neoplasms. |
| More detail of all 2 literatures about FRK | |
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Pathways and Diseases |
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Pathway | Axon guidance mediated by semaphorins;PANTHER;P00007 |
Pathway | Cadherin signaling pathway;PANTHER;P00012 |
Pathway | Parkinson disease;PANTHER;P00049 |
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External Links |
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Links to Entrez Gene | 2444 |
Links to all GeneRIF Items | 2444 |
Links to iHOP | 2444 |
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Sequence Information |
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Nucleotide Sequence |
>2444 : length: 1518 atgagcaacatctgtcagaggctctgggagtacctagaaccctatctcccctgtttgtcc acggaggcagacaagtcaaccgtgattgaaaatccaggggccctttgctctccccagtca cagaggcatggccactactttgtggctttgtttgattaccaggctcggactgctgaggac ttgagcttccgagcaggtgacaaacttcaagttctggacactttgcatgagggctggtgg tttgccagacacttggagaaaagacgagatggctccagtcagcaactacaaggctatatt ccttctaactacgtggctgaggacagaagcctacaggcagagccgtggttctttggagca atcggaagatcagatgcagagaaacaactattatattcagaaaacaagaccggttccttt ctaatcagagaaagtgaaagccaaaaaggagaattctctctttcagttttagatggagca gttgtaaaacactacagaattaaaagactggatgaagggggattttttctcacgcgaaga agaatcttttcaacactgaacgaatttgtgagccactacaccaagacaagtgacggcctg tgtgtcaagctggggaaaccatgcttaaagatccaggtcccagctccatttgatttgtcg tataaaaccgtggaccaatgggagatagaccgcaactccatacagcttctgaagcgattg ggatctggtcagtttggcgaagtatgggaaggtctgtggaacaataccactccagtagca gtgaaaacattaaaaccaggttcaatggatccaaatgacttcctgagggaggcacagata atgaagaacctaagacatccaaagcttatccagctttatgctgtttgcactttagaagat ccaatttatattattacagagttgatgagacatggaagtctgcaagaatatctccaaaat gacactggatcaaaaatccatctgactcaacaggtagacatggcggcacaggttgcctct ggaatggcctatctggagtctcggaactacattcacagagatctggctgccagaaatgtc ctcgttggtgaacataatatctacaaagtagcagattttggacttgccagagtttttaag gtagataatgaagacatctatgaatctagacacgaaataaagctgccggtgaagtggact gcgcccgaagccattcgtagtaataaattcagcattaagtccgatgtatggtcatttgga atccttctttatgaaatcattacttatggcaaaatgccttacagtggtatgacaggtgcc caggtaatccagatgttggctcaaaactatagacttccgcaaccatccaactgtccacag caattttacaacatcatgttggagtgctggaatgcagagcctaaggaacgacctacattt gagacactgcgttggaaacttgaagactattttgaaacagactcttcatattcagatgca aataacttcataagatga |
Protein Sequence |
>2444 : length: 505 MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAED LSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGA IGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRR RIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRL GSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLED PIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNV LVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFG ILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTF ETLRWKLEDYFETDSSYSDANNFIR |