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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 26524 |
Name | LATS2 |
Synonym | KPM;LATS, large tumor suppressor, homolog 2 (Drosophila);LATS2;LATS, large tumor suppressor, homolog 2 (Drosophila) |
Definition | LATS (large tumor suppressor, Drosophila) homolog 2|kinase phosphorylated during mitosis protein|large tumor suppressor homolog 2|serine/threonine kinase KPM|serine/threonine-protein kinase LATS2|serine/threonine-protein kinase kpm|warts-like kinase |
Position | 13q11-q12 |
Gene Type | protein-coding |
Source | Count: 3; Pubmed_search,UniProt,Generif |
Literature support | Count: 18 PubMed records as below. |
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Evidence Status |
Description |
reviewed | KIBRA associates with and activates Lats (large tumor suppressor) 1 and 2 kinases by stimulating their phosphorylation on the hydrophobic motif. |
reviewed | The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals. |
reviewed | "Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts." |
reviewed | MicroRNA-31 regulated by the extracellular regulated kinase is involved in vascular smooth muscle cell growth via large tumor suppressor homolog 2. |
reviewed | Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor. |
reviewed | The tumor suppressor Lats2 is pivotal in Aurora A and Aurora B signaling during mitosis. |
reviewed | "Results reveal a functional connection between the pRB and Hippo tumor suppressor pathways, and suggest that low levels of LATS2 may undermine the ability of pRB to induce a permanent cell cycle arrest in tumor cells." |
reviewed | Identification of a tumor suppressor relay between the FOXP3 and the Hippo pathways in breast and prostate cancers. |
reviewed | LATS2 is a tumor suppressor gene of malignant mesothelioma. |
reviewed | LATS2 tumor suppressor gene is regulated by tristetraprolin. |
| More detail of all 18 literatures about LATS2 | |
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Pathways and Diseases |
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Pathway | Coregulation of Androgen receptor activity;PID Curated;200038 |
Disease | Brain tumor;FunDO |
Disease | Breast cancer;FunDO |
Disease | Lung cancer;FunDO |
Disease | Prostate cancer;FunDO |
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External Links |
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Links to Entrez Gene | 26524 |
Links to all GeneRIF Items | 26524 |
Links to iHOP | 26524 |
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Sequence Information |
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Nucleotide Sequence |
>26524 : length: 3267 atgaggccaaagacttttcctgccacgacttattctggaaatagccggcagcgactgcaa gagattcgtgaggggttaaaacagccatccaagtcttcggttcaggggctacccgcagga ccaaacagtgacacttccctggatgccaaagtcctggggagcaaagatgccaccaggcag cagcagcagatgagagccaccccaaagttcggaccttatcagaaagccttgagggaaatc agatattccttgttgccttttgctaatgaatcgggcacctctgcagctgcagaagtgaac cggcaaatgctgcaggaactggtgaacgcaggatgcgaccaggagatggctggccgagct ctcaagcagactggcagcaggagcatcgaggccgccctggagtacatcagcaagatgggc tacctggacccgaggaatgagcagattgtgcgggtcattaagcagacctccccaggaaag gggctcatgccaaccccagtgacgcggaggcccagcttcgaaggaaccggcgattcgttt gcgtcctaccaccagctgagcggtaccccctacgagggcccaagcttcggcgctgacggc cccacggcgctggaggagatgccgcggccgtacgtggactaccttttccccggagtcggc ccccacgggcccggccaccagcaccagcacccacccaagggctacggtgccagcgtagag gcagcaggggcacacttcccgctgcagggcgcgcactacgggcggccgcacctgctggtg cctggggaacccctgggctacggagtgcagcgcagcccctccttccagagcaagacgccg ccggagaccgggggttacgccagcctgcccacgaagggccagggaggaccgccaggcgcc ggcctcgctttcccaccccctgccgccgggctctacgtgccgcacccacaccacaagcag gccggtcccgcggcccaccagctgcatgtgctgggctcccgcagccaggtgttcgccagc gacagccccccgcagagcctgctcactccctcgcggaacagcctcaacgtggacctgtat gaattgggcagcacctccgtccagcagtggccggctgccaccctggcccgccgggactcc ctgcagaagccgggcctggaggcgccgccgcgcgcgcacgtggccttccggcctgactgc ccagtgcccagcaggaccaactccttcaacagccaccagccgcggcccggtccgcctggc aaggccgagccctccctgcccgcccccaacaccgtgacggctgtcacggccgcgcacatc ttgcacccggtgaagagcgtgcgtgtgctgaggccggagccgcagacggctgtggggccc tcgcaccccgcctgggtgcccgcgcctgccccggcccccgcccccgcccccgccccggct gcggagggcttggacgccaaggaggagcatgccctggcgctgggcggcgcaggcgccttc ccgctggacgtggagtacggaggcccagaccggaggtgcccgcctccgccctacccgaag cacctgctgctgcgcagcaagtcggagcagtacgacctggacagcctgtgcgcaggcatg gagcagagcctccgtgcgggccccaacgagcccgagggcggcgacaagagccgcaaaagc gccaagggggacaaaggcggaaaggataaaaagcagattcagacctctcccgttcccgtc cgcaaaaacagcagagacgaagagaagagagagtcacgcatcaagagctactcgccatac gcctttaagttcttcatggagcagcacgtggagaatgtcatcaaaacctaccagcagaag gttaaccggaggctgcagctggagcaagaaatggccaaagctggactctgtgaagctgag caggagcagatgcggaagatcctctaccagaaagagtctaattacaacaggttaaagagg gccaagatggacaagtctatgtttgtcaagatcaaaaccctggggatcggtgcctttgga gaagtgtgccttgcttgtaaggtggacactcacgccctgtacgccatgaagaccctaagg aaaaaggatgtcctgaaccggaatcaggtggcccacgtcaaggccgagagggacatcctg gccgaggcagacaatgagtgggtggtcaaactctactactccttccaagacaaagacagc ctgtactttgtgatggactacatccctggtggggacatgatgagcctgctgatccggatg gaggtcttccctgagcacctggcccggttctacatcgcagagctgactttggccattgag agtgtccacaagatgggcttcatccaccgagacatcaagcctgataacattttgatagat ctggatggtcacattaaactcacagatttcggcctctgcactgggttcaggtggactcac aattccaaatattaccagaaagggagccatgtcagacaggacagcatggagcccagcgac ctctgggatgatgtgtctaactgtcggtgtggggacaggctgaagaccctagagcagagg gcgcggaagcagcaccagaggtgcctggcacattcactggtggggactccaaactacatc gcacccgaggtgctcctccgcaaagggtacactcaactctgtgactggtggagtgttgga gtgattctcttcgagatgctggtggggcagccgccctttttggcacctactcccacagaa acccagctgaaggtgatcaactgggagaacacgctccacattccagcccaggtgaagctg agccctgaggccagggacctcatcaccaagctgtgctgctccgcagaccaccgcctgggg cggaatggggccgatgacctgaaggcccaccccttcttcagcgccattgacttctccagt gacatccggaagcagccagccccctacgttcccaccatcagccaccccatggacacctcg aatttcgaccccgtagatgaagaaagcccttggaacgatgccagcgaaggtagcaccaag gcctgggacacactcacctcgcccaataacaagcatcctgagcacgcattttacgaattc accttccgaaggttctttgatgacaatggctacccctttcgatgcccaaagccttcagga gcagaagcttcacaggctgagagctcagatttagaaagctctgatctggtggatcagact gaaggctgccagcctgtgtacgtgtag |
Protein Sequence |
>26524 : length: 1088 MRPKTFPATTYSGNSRQRLQEIREGLKQPSKSSVQGLPAGPNSDTSLDAKVLGSKDATRQ QQQMRATPKFGPYQKALREIRYSLLPFANESGTSAAAEVNRQMLQELVNAGCDQEMAGRA LKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTSPGKGLMPTPVTRRPSFEGTGDSF ASYHQLSGTPYEGPSFGADGPTALEEMPRPYVDYLFPGVGPHGPGHQHQHPPKGYGASVE AAGAHFPLQGAHYGRPHLLVPGEPLGYGVQRSPSFQSKTPPETGGYASLPTKGQGGPPGA GLAFPPPAAGLYVPHPHHKQAGPAAHQLHVLGSRSQVFASDSPPQSLLTPSRNSLNVDLY ELGSTSVQQWPAATLARRDSLQKPGLEAPPRAHVAFRPDCPVPSRTNSFNSHQPRPGPPG KAEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGPSHPAWVPAPAPAPAPAPAPA AEGLDAKEEHALALGGAGAFPLDVEYGGPDRRCPPPPYPKHLLLRSKSEQYDLDSLCAGM EQSLRAGPNEPEGGDKSRKSAKGDKGGKDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPY AFKFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKR AKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDIL AEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIE SVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSD LWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVG VILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLG RNGADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTK AWDTLTSPNNKHPEHAFYEFTFRRFFDDNGYPFRCPKPSGAEASQAESSDLESSDLVDQT EGCQPVYV |