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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 27330 |
Name | RPS6KA6 |
Synonym | PP90RSK4|RSK4;ribosomal protein S6 kinase, 90kDa, polypeptide 6;RPS6KA6;ribosomal protein S6 kinase, 90kDa, polypeptide 6 |
Definition | 90 kDa ribosomal protein S6 kinase 6|RSK-4|S6K-alpha 6|S6K-alpha-6|p90-RSK 6|p90RSK6|ribosomal S6 kinase 4|ribosomal protein S6 kinase alpha-6 |
Position | Xq21 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 2 PubMed records as below. |
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Evidence Status |
Description |
potential | Results support the concept that RSK4 may be an important tumor suppressor gene by modulating senescence induction and contributing to cell proliferation control in colon carcinogenesis and renal cell carcinomas. |
potential | "RT-PCR data show high expression of putative tumor suppressor genes Rsk4 and RbAp46 in 47% and 79% of breast carcinoma cases, respectively, whereas Cldn2 was down-regulated in 52% of breast cancer cases compared with normal adjacent tissues." |
| More detail of all 2 literatures about RPS6KA6 | |
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Pathways and Diseases |
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Pathway | Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | Long-term potentiation;KEGG PATHWAY;hsa04720 |
Pathway | Progesterone-mediated oocyte maturation;KEGG PATHWAY;hsa04914 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | PDGF signaling pathway;PANTHER;P00047 |
Pathway | Synaptic Transmission;Reactome;REACT:13685 |
Pathway | Oocyte meiosis;KEGG PATHWAY;hsa04114 |
Pathway | Interleukin signaling pathway;PANTHER;P00036 |
Pathway | mTOR signaling pathway;KEGG PATHWAY;hsa04150 |
Pathway | Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade;PANTHER;P00032 |
Pathway | Ras Pathway;PANTHER;P04393 |
Disease | Breast cancer;FunDO |
Disease | Colon cancer;FunDO |
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External Links |
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Links to Entrez Gene | 27330 |
Links to all GeneRIF Items | 27330 |
Links to iHOP | 27330 |
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Sequence Information |
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Nucleotide Sequence |
>27330 : length: 2238 atgctaccattcgctcctcaggacgagccctgggaccgagaaatggaagtgttcagcggc ggcggcgcgagcagcggcgaggtaaatggtcttaaaatggttgatgagccaatggaagag ggagaagcagattcttgtcatgatgaaggagttgttaaagaaatccctattactcatcat gttaaggaaggctatgagaaagcagatcctgcacagtttgagttgctcaaggttcttggt caggggtcatttggaaaggtttttcttgttagaaagaagaccggtcctgatgctgggcag ctctatgcaatgaaggtgttaaaaaaagcctctttaaaagttcgagacagagttcggaca aagatggagagggatatactggtggaagtaaatcatccatttattgtcaaattgcactat gcctttcagactgaagggaaactgtacttaatactggattttctcaggggaggagatgtt ttcacaagattatccaaagaggttctgtttacagaggaagatgtgaaattctacctcgca gaactggcccttgctttggatcatctgcaccaattaggaattgtttatagagacctgaag ccagaaaacattttgcttgatgaaataggacatatcaaattaacagattttggactcagc aaggagtcagtagatcaagaaaagaaggcttactcattttgtggtacagtagagtatatg gctcctgaagtagtaaataggagaggccattcccagagtgctgattggtggtcatatggt gttcttatgtttgaaatgcttactggtactctgccatttcaaggtaaagacagaaatgag accatgaatatgatattaaaagcaaaacttggaatgcctcaatttcttagtgctgaagca caaagtcttctaaggatgttattcaaaaggaatccagcaaatagattgggatcagaagga gttgaagaaatcaaaagacatctgttttttgcaaatattgactgggataaattatataaa agagaagttcaacctcctttcaaacctgcttctggaaaaccagatgatactttttgtttt gatcctgaatttactgcaaaaacacctaaagattctcccggtttgccagccagtgcaaat gctcatcagctcttcaaaggattcagctttgttgcaacttctattgcagaagaatataaa atcactcctatcacaagtgcaaatgtattaccaattgttcagataaatggaaatgctgca caatttggtgaagtatatgaattgaaggaggatattggtgttggctcctactctgtttgc aagcgatgcatacatgcaactaccaacatggaatttgcagtgaagatcattgacaaaagt aagcgagacccttcagaagagattgaaatattgatgcgctatggacaacatcccaacatt attactttgaaggatgtctttgatgatggtagatatgtttaccttgttacggatttaatg aaaggaggagagttacttgaccgtattctcaaacaaaaatgtttctcggaacgggaggct agtgatatactatatgtaataagtaagacagttgactatcttcattgtcaaggagttgtt catcgtgatcttaaacctagtaatattttatacatggatgaatcagccagtgcagattca atcaggatatgtgattttgggtttgcaaaacaacttcgaggagaaaatggacttctctta actccatgctacactgcaaactttgttgcacctgaggttcttatgcaacagggatatgat gctgcttgtgatatctggagtttaggagtccttttttacacaatgttggctggctacact ccatttgctaatggccccaatgatactcctgaagagatactgctgcgtataggcaatgga aaattctctttgagtggtggaaactgggacaatatttcagacggagcaaaggatttgctt tcccatatgcttcatatggacccacatcagcggtatactgctgaacaaatattaaagcac tcatggataactcacagagaccagttgccaaatgatcagccaaagagaaatgatgtgtca catgttgttaagggagcaatggttgcaacatactctgccctgactcacaagacctttcaa ccagtcctagagcctgtagctgcttcaagcttagcccagcgacggagcatgaaaaagcga acatcaactggcctgtaa |
Protein Sequence |
>27330 : length: 745 MLPFAPQDEPWDREMEVFSGGGASSGEVNGLKMVDEPMEEGEADSCHDEGVVKEIPITHH VKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRT KMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLA ELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYM APEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEA QSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCF DPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPIVQINGNAA QFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQHPNI ITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVV HRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYD AACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLL SHMLHMDPHQRYTAEQILKHSWITHRDQLPNDQPKRNDVSHVVKGAMVATYSALTHKTFQ PVLEPVAASSLAQRRSMKKRTSTGL |