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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 274 |
Name | BIN1 |
Synonym | AMPH2|AMPHL|SH3P9;bridging integrator 1;BIN1;bridging integrator 1 |
Definition | amphiphysin II|amphiphysin-like protein|box dependant MYC interacting protein 1|box-dependent myc-interacting protein 1|myc box-dependent-interacting protein 1 |
Position | 2q14 |
Gene Type | protein-coding |
Source | Count: 4; Pubmed_search,TAG,Generif,UniProt |
Literature support | Count: 6 PubMed records as below. |
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Evidence Status |
Description |
potential | A role for the putative tumor suppressor Bin1 in muscle cell differentiation. |
reviewed | A nucleocytosolic myc-interacting isoform of Bin1 has properties of a tumor suppressor. |
reviewed | The c-MYC-interacting proapoptotic tumor suppressor BIN1 is a transcriptional target for E2F1 in response to DNA damage. |
reviewed | Loss of heterozygosity and tumor suppressor activity of Bin1 in prostate carcinoma. |
reviewed | Losses of the tumor suppressor BIN1 in breast carcinoma are frequent and reflect deficits in programmed cell death capacity. |
reviewed | Missplicing of a brain-specific exon of Bin1 in human melanoma is sufficient to abolish tumor suppressor properties; ectopic WT Bin1 activates PCD in malignant but not normal melanocytes. |
| More detail of all 6 literatures about BIN1 | |
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Pathways and Diseases |
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Pathway | endocytotic role of ndk phosphins and dynamin;PID BioCarta;100099 |
Pathway | Arf6 trafficking events;PID Curated;200046 |
Disease | Myopathy, centronuclear, autosomal recessive;OMIM |
Disease | Cancer;FunDO |
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External Links |
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Links to Entrez Gene | 274 |
Links to all GeneRIF Items | 274 |
Links to iHOP | 274 |
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Sequence Information |
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Nucleotide Sequence |
>274 : length: 1365 atggcagagatgggcagtaaaggggtgacggcgggaaagatcgccagcaacgtgcagaag aagctcacccgcgcgcaggagaaggttctccagaagctggggaaggcagatgagaccaag gatgagcagtttgagcagtgcgtccagaatttcaacaagcagctgacggagggcacccgg ctgcagaaggatctccggacctacctggcctccgtcaaagccatgcacgaggcttccaag aagctgaatgagtgtctgcaggaggtgtatgagcccgattggcccggcagggatgaggca aacaagatcgcagagaacaacgacctgctgtggatggattaccaccagaagctggtggac caggcgctgctgaccatggacacgtacctgggccagttccccgacatcaagtcacgcatt gccaagcgggggcgcaagctggtggactacgacagtgcccggcaccactacgagtccctt caaactgccaaaaagaaggatgaagccaaaattgccaaggccgaggaggagctcatcaaa gcccagaaggtgtttgaggagatgaatgtggatctgcaggaggagctgccgtccctgtgg aacagccgcgtaggtttctacgtcaacacgttccagagcatcgcgggcctggaggaaaac ttccacaaggagatgagcaagctcaaccagaacctcaatgatgtgctggtcggcctggag aagcaacacgggagcaacaccttcacggtcaaggcccagcccagaaagaaaagtaaactg ttttcgcggctgcgcagaaagaagaacagtgacaacgcgcctgcaaaagggaacaagagc ccttcgcctccagatggctcccctgccgccacccccgagatcagagtcaaccacgagcca gagccggccggcggggccacgcccggggccaccctccccaagtccccatctcagccagca gaggcctcggaggtggcgggtgggacccaacctgcggctggagcccaggagccaggggag acggcggcaagtgaagcagcctccagctctcttcctgctgtcgtggtggagaccttccca gcaactgtgaatggcaccgtggagggcggcagtggggccgggcgcttggacctgccccca ggtttcatgttcaaggtacaggcccagcacgactacacggccactgacacagacgagctg cagctcaaggctggtgatgtggtgctggtgatccccttccagaaccctgaagagcaggat gaaggctggctcatgggcgtgaaggagagcgactggaaccagcacaaggagctggagaag tgccgtggcgtcttccccgagaacttcactgagagggtcccatga |
Protein Sequence |
>274 : length: 454 MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTR LQKDLRTYLASVKAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVD QALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQTAKKKDEAKIAKAEEELIK AQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVGLE KQHGSNTFTVKAQPRKKSKLFSRLRRKKNSDNAPAKGNKSPSPPDGSPAATPEIRVNHEP EPAGGATPGATLPKSPSQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFP ATVNGTVEGGSGAGRLDLPPGFMFKVQAQHDYTATDTDELQLKAGDVVLVIPFQNPEEQD EGWLMGVKESDWNQHKELEKCRGVFPENFTERVP |