|
|
||
|
|
||
| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 3090 |
Name | HIC1 |
Synonym | ZBTB29|ZNF901|hic-1;hypermethylated in cancer 1;HIC1;hypermethylated in cancer 1 |
Definition | hypermethylated in cancer 1 protein|zinc finger and BTB domain-containing protein 29 |
Position | 17p13.3 |
Gene Type | protein-coding |
Source | Count: 3; Pubmed_search,UniProt,Generif |
Literature support | Count: 18 PubMed records as below. |
|
Evidence Status |
Description |
potential | The carboxy-terminal end of the candidate tumor suppressor gene HIC-1 is phylogenetically conserved. |
potential | Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer. |
reviewed | "Alterations in Promoter Methylation Status of tumor suppressor HIC1, SFRP2, and DAPK1 Genes in Prostate Carcinomas." |
reviewed | Retraction. Requirement for chromatin-remodeling complex in novel tumor suppressor HIC1-mediated transcriptional repression and growth control. |
reviewed | Identification of novel subregions of LOH in gastric cancer and analysis of the HIC1 and TOB1 tumor suppressor genes in these subregions. |
reviewed | "Promoter hypermethylation of RASSF1A, MGMT, and HIC-1 genes in benign and malignant colorectal tumors." |
reviewed | Data report that novel tumor suppressor HIC1 is required for growth suppression by estrogen antagonists in breast cancer cells. |
reviewed | "The tumor suppressor HIC1 is implicated in the transcriptional regulation of the chemokine receptor CXCR7, a key player in the promotion of tumorigenesis in a wide variety of cell types." |
reviewed | The tumor suppressor gene hypermethylated in cancer 1 is transcriptionally regulated by E2F1. |
potential | Detailed mapping of chromosome 17p deletions reveals HIC1 as a novel tumor suppressor gene candidate telomeric to TP53 in diffuse large B-cell lymphoma. |
| More detail of all 18 literatures about HIC1 | |
|
Pathways and Diseases |
|
Pathway | E2F transcription factor network;PID Curated;200027 |
Pathway | Direct p53 effectors;PID Curated;200101 |
Pathway | hypoxia and p53 in the cardiovascular system;PID BioCarta;100084 |
|
External Links |
|
Links to Entrez Gene | 3090 |
Links to all GeneRIF Items | 3090 |
Links to iHOP | 3090 |
|
Sequence Information |
|
Nucleotide Sequence |
>3090 : length: 2202 atgacttttcctgaagcggacattttacttaaatcgggagagtgtgctgggcagacgatg ctggacacgatggaggcgcccggccactccaggcagctgctgctgcagctcaacaaccag cgcaccaagggcttcttgtgcgacgtgatcatcgtggtgcagaacgccctcttccgcgcg cacaagaacgtgctggcggccagcagcgcctacctcaagtccctggtggtgcatgacaac ctgctcaacctggaccatgacatggtgagcccggccgtgttccgcctggtgctggacttc atctacaccggccgcctggctgacggcgcagaggcggctgcggccgcggccgtggccccg ggggctgagccgagcctgggcgccgtgctggccgccgccagctacctgcagatccccgac ctcgtggcgctgtgcaagaaacgcctcaagcgccacggcaagtactgccacctgcggggc ggcggcggcggcggcggcggctacgcgccctatggtcggccgggccggggcctgcgggcc gccacgccggtcatccaggcctgctacccgtccccagtcgggcctccgccgccgcctgcc gcggagccgccctcgggcccagaggccgcggtcaacacgcactgcgccgagctgtacgcg tcgggacccggcccggccgccgcactctgtgcctcggagcgccgctgctcccctctttgt ggcctggacctgtccaagaagagcccgccgggctccgcggcgccagagcggccgctggct gagcgcgagctgcccccgcgcccggacagccctcccagcgccggccccgccgcctacaag gagccgcctctcgccctgccgtcgctgccgccgctgcccttccagaagctggaggaggcc gcaccgccttccgacccatttcgcggcggcagcggcagcccgggacccgagccccccggc cgccccgacgggcctagtctcctctatcgctggatgaagcacgagccgggcctgggtagc tatggcgacgagctgggccgggagcgcggctcccccagcgagcgctgcgaagagcgtggt ggggacgcggccgtctcgcccggggggcccccgctcggcctggcgccgccgccgcgctac cctggcagcctggacgggcccggcgcgggcggcgacggcgacgactacaagagcagcagc gaggagaccggtagcagcgaggaccccagcccgcctggcggccacctcgagggctaccca tgcccgcacctggcctatggcgagcccgagagcttcggtgacaacctgtacgtgtgcatt ccgtgcggcaagggcttccccagctctgagcagctgaacgcgcacgtggaggctcacgtg gaggaggaggaagcgctgtacggcagggccgaggcggccgaagtggccgctggggccgcc ggcctagggcccccttttggaggcggcggggacaaggtcgccggggctccgggtggcctg ggagagctgctgcggccctaccgctgcgcgtcgtgcgacaagagctacaaggacccggcc acgctgcggcagcacgagaagacgcactggctgacccggccctacccatgcaccatctgc gggaagaagttcacgcagcgtgggaccatgacgcgccacatgcgcagccacctgggcctc aagcccttcgcgtgcgacgcgtgcggcatgcggttcacgcgccagtaccgcctcacggag cacatgcgcatccactcgggcgagaagccctacgagtgccaggtgtgcggcggcaagttc gcacagcaacgcaacctcatcagccacatgaagatgcacgccgtggggggcgcggccggc gcggccggggcgctggcgggcttgggggggctccccggcgtccccggccccgacggcaag ggcaagctcgacttccccgagggcgtctttgctgtggctcgcctcacggccgagcagctg agcctgaagcagcaggacaaggcggccgcggccgagctgctggcgcagaccacgcacttc ctgcacgaccccaaggtggcgctggagagcctctacccgctggccaagttcacggccgag ctgggcctcagccccgacaaggcggccgaggtgctgagccagggcgctcacctggcggcc gggcccgacggccggaccatcgaccgtttctctcccacctag |
Protein Sequence |
>3090 : length: 733 MTFPEADILLKSGECAGQTMLDTMEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRA HKNVLAASSAYLKSLVVHDNLLNLDHDMVSPAVFRLVLDFIYTGRLADGAEAAAAAAVAP GAEPSLGAVLAAASYLQIPDLVALCKKRLKRHGKYCHLRGGGGGGGGYAPYGRPGRGLRA ATPVIQACYPSPVGPPPPPAAEPPSGPEAAVNTHCAELYASGPGPAAALCASERRCSPLC GLDLSKKSPPGSAAPERPLAERELPPRPDSPPSAGPAAYKEPPLALPSLPPLPFQKLEEA APPSDPFRGGSGSPGPEPPGRPDGPSLLYRWMKHEPGLGSYGDELGRERGSPSERCEERG GDAAVSPGGPPLGLAPPPRYPGSLDGPGAGGDGDDYKSSSEETGSSEDPSPPGGHLEGYP CPHLAYGEPESFGDNLYVCIPCGKGFPSSEQLNAHVEAHVEEEEALYGRAEAAEVAAGAA GLGPPFGGGGDKVAGAPGGLGELLRPYRCASCDKSYKDPATLRQHEKTHWLTRPYPCTIC GKKFTQRGTMTRHMRSHLGLKPFACDACGMRFTRQYRLTEHMRIHSGEKPYECQVCGGKF AQQRNLISHMKMHAVGGAAGAAGALAGLGGLPGVPGPDGKGKLDFPEGVFAVARLTAEQL SLKQQDKAAAAELLAQTTHFLHDPKVALESLYPLAKFTAELGLSPDKAAEVLSQGAHLAA GPDGRTIDRFSPT |