Basic Information
Gene ID	3090
Name	HIC1
Synonymous	ZBTB29\|ZNF901\|hic-1;hypermethylated in cancer 1;HIC1;hypermethylated in cancer 1
Definition	hypermethylated in cancer 1 protein\|zinc finger and BTB domain-containing protein 29
Position	17p13.3
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Transcription Factors

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Regulation From TransFac database
HIC-1-isoform2(h) + TCF-4-isoform8(h) <==> HIC-1-isoform2(h):TCF-4-isoform8(h) (binding)
CtBP1(h) + HIC-1-isoform2(h) <==> CtBP1(h):HIC-1-isoform2(h) (binding)
CtBP2(h) + HIC-1-isoform2(h) <==> CtBP2(h):HIC-1-isoform2(h) (binding)
MTA-1long(h) + HIC-1-isoform2(h) <==> MTA-1long(h):HIC-1-isoform2(h) (binding)
HIC-1-isoform2(h) + MTA-1(m.s.) <==> HIC-1-isoform2(h):MTA-1(m.s.) (binding)
HIC-1-isoform2(h) + MTA-1(h) + mbd3(h) + Mi2-alpha(h) <==> HIC-1-isoform2(h):MTA-1(h):mbd3(h):Mi2-alpha(h) (binding)
HIC-1-isoform2(h) + RbAp48(m.s.) <==> HIC-1-isoform2(h):RbAp48(m.s.) (binding)
HIC-1-isoform2(h) + acetyl-CoA --p300(m.s.)--> HIC-1-isoform2(h){aceK314} + CoA (acetylation)
HIC-1-isoform2(h) --/ p57Kip2(m) (decrease of abundance)
HIC-1-isoform2(h) --/ cyclinD1(m) (decrease of abundance)
HIC1(h) --> HIC-1-isoform2(h) (expression).
HIC-1(h) --/ AXIN2(m) (transrepression)
HIC-1(h) --/ SP5(h) (transrepression)
HIC-1(h) --/ CCND1(h) (transrepression)
TCF-4(h) + beta-catenin(h) + HIC-1(h) <==> TCF-4(h):beta-catenin(h):HIC-1(h) (binding)
HIC-1(h) + MBD2(m.s.) <==> HIC-1(h):MBD2(m.s.) (binding)
mbd3(m.s.) + HIC-1(h) <==> mbd3(m.s.):HIC-1(h) (binding)
mbd3(h) + HIC-1(h) <==> mbd3(h):HIC-1(h) (binding)
HIC1(h) --> HIC-1(h) (expression).
HIC1(h) --> HIC-1-isoform1(h) (expression).

Location (AA)	PTM type	Database
313	Phosphoserine (By similarity).	Swiss-Prot 53.0
333	N6-acetyllysine; alternate.	Swiss-Prot 53.0
333	Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO);alternate.	Swiss-Prot 53.0

Chromosome	Location	Source
chr17	Promoter: 1903513 - 1905513	GoldenGate_Methylation_Cancer_Panel_I
chr17	Promoter: 1903513 - 1905513	GSE27584
chr17	Promoter: 1903513 - 1905513	PMID:14688019
chr17	Promoter: 1903513 - 1905513	PMID:12097291
chr17	Promoter: 1903513 - 1905513	PMID:14506157
chr17	Promoter: 1903513 - 1905513	PMID:14656076
chr17	Promoter: 1903513 - 1905513	PMID:9671399
chr17	Promoter: 1903513 - 1905513	PMID:11448914
chr17	Promoter: 1903513 - 1905513	PMID:15713962
chr17	Promoter: 1903513 - 1905513	PMID:12773202
chr17	Promoter: 1903513 - 1905513	PMID:16204069
chr17	Promoter: 1903513 - 1905513	PMID:12429618
chr17	Promoter: 1903513 - 1905513	PMID:17177027
chr17	Promoter: 1903513 - 1905513	PMID:14714493
chr17	Promoter: 1903513 - 1905513	PMID:11895880
chr17	Promoter: 1903513 - 1905513	PMID:16435073
chr17	Promoter: 1903513 - 1905513	PMID:16166431
chr17	Promoter: 1903513 - 1905513	PMID:9572497
chr17	Promoter: 1903513 - 1905513	PMID:15328171
chr17	Promoter: 1903513 - 1905513	PMID:15026333
chr17	Promoter: 1903513 - 1905513	PMID:17380894
chr17	Promoter: 1903513 - 1905513	PMID:15788647
chr17	Promoter: 1903513 - 1905513	PMID:15389252
chr17	Promoter: 1903513 - 1905513	PMID:11341745
chr17	Promoter: 1903513 - 1905513	PMID:15885882
chr17	Promoter: 1903513 - 1905513	PMID:16412291
chr17	Promoter: 1903513 - 1905513	PMID:16343268
chr17	Promoter: 1903513 - 1905513	PMID:15507671