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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 324 |
Name | APC |
Synonym | BTPS2|DP2|DP2.5|DP3|GS|PPP1R46;adenomatous polyposis coli;APC;adenomatous polyposis coli |
Definition | adenomatosis polyposis coli tumor suppressor|adenomatous polyposis coli protein|deleted in polyposis 2.5|protein phosphatase 1, regulatory subunit 46 |
Position | 5q21-q22 |
Gene Type | protein-coding |
Source | Count: 4; Pubmed_search,TAG,UniProt,Generif |
Literature support | Count: 60 PubMed records as below. |
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Evidence Status |
Description |
reviewed | "Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta." |
reviewed | Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein. |
reviewed | Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein. |
reviewed | Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein. |
reviewed | Association of the APC tumor suppressor protein with catenins. |
reviewed | "Association of plakoglobin with APC, a tumor suppressor gene product, and its regulation by tyrosine phosphorylation." |
reviewed | The tumor suppressor adenomatous polyposis coli controls the direction in which a cell extrudes from an epithelium. |
reviewed | Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?. |
reviewed | Hepatitis B viral X protein interacts with tumor suppressor adenomatous polyposis coli to activate Wnt/β-catenin signaling. |
reviewed | Loss of the APC tumor suppressor gene causes upregulation of a DNA demethylase system; tissues taken from human subjects showed the demethylation of these same key developmental genes in human colon adenomas. |
| More detail of all 60 literatures about APC | |
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Pathways and Diseases |
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Pathway | Presenilin action in Notch and Wnt signaling;PID Curated;200052 |
Pathway | Wnt signaling pathway;KEGG PATHWAY;hsa04310 |
Pathway | Regulation of Wnt-mediated beta catenin signaling and target gene transcription;PID Curated;200106 |
Pathway | Apoptosis;Reactome;REACT:578 |
Pathway | Canonical Wnt signaling pathway;PID Curated;200064 |
Pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met);PID Curated;200032 |
Pathway | Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810 |
Pathway | CDC42 signaling events;PID Curated;200057 |
Pathway | Wnt signaling pathway;PANTHER;P00057 |
Pathway | Direct p53 effectors;PID Curated;200101 |
Pathway | Endometrial cancer;KEGG PATHWAY;hsa05213 |
Pathway | Signaling by Wnt;Reactome;REACT:11045 |
Pathway | Regulation of CDC42 activity;PID Curated;200059 |
Pathway | Basal cell carcinoma;KEGG PATHWAY;hsa05217 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Colorectal cancer;KEGG PATHWAY;hsa05210 |
Disease | colon adenomas/carcinomas;GAD |
Disease | Gastric cancer;KEGG DISEASE;H00018 |
Disease | late onset of familial adenomatous polyposis;GAD |
Disease | Adenomatous polyposis coli;OMIM |
Disease | Gastric cancer, somatic;OMIM |
Disease | decreased apoptotic level;GAD |
Disease | Brain tumor-polyposis syndrome 2;OMIM |
Disease | hepatocellular carcinoma;GAD |
Disease | Pervasive development disorder;FunDO |
Disease | Hepatoblastoma;OMIM |
Disease | Ulcerative colitis;FunDO |
Disease | Desmoid disease, hereditary;OMIM |
Disease | Cancer of the anal canal;KEGG DISEASE;H00044 |
Disease | Colorectal cancer, somatic;OMIM |
Disease | beta-catenin;GAD |
Disease | Cancers of the digestive system;KEGG DISEASE |
Disease | Schizophrenia;FunDO |
Disease | Adenomatous Polyposis Coli;GAD |
Disease | colorectal cancer;GAD |
Disease | PSYCH;GAD |
Disease | adenomatous polyposis;GAD |
Disease | colorectal adenocarcinomas;GAD |
Disease | Venous Thrombosis;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | CANCER;GAD |
Disease | familial adenomatous polyposis.;GAD |
Disease | severe desmoid phenotype;GAD |
Disease | Adenoma, periampullary;OMIM |
Disease | colorectal adenomas;GAD |
Disease | Gallbladder cancer;KEGG DISEASE;H00047 |
Disease | late onset familial adenomatous polyposis;GAD |
Disease | diet lifestyle and risk of colon cancer;GAD |
Disease | Cancers;KEGG DISEASE |
Disease | stomach cancer;GAD |
Disease | Barrett's esophagus;FunDO |
Disease | Congenital abnormality;FunDO |
Disease | Autism;GAD |
Disease | Cancer;FunDO |
Disease | Esophageal cancer;KEGG DISEASE;H00017 |
Disease | Gardner syndrome;OMIM |
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External Links |
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Links to Entrez Gene | 324 |
Links to all GeneRIF Items | 324 |
Links to iHOP | 324 |
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Sequence Information |
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Nucleotide Sequence |
>324 : length: 8532 atggctgcagcttcatatgatcagttgttaaagcaagttgaggcactgaagatggagaac tcaaatcttcgacaagagctagaagataattccaatcatcttacaaaactggaaactgag gcatctaatatgaaggaagtacttaaacaactacaaggaagtattgaagatgaagctatg gcttcttctggacagattgatttattagagcgtcttaaagagcttaacttagatagcagt aatttccctggagtaaaactgcggtcaaaaatgtccctccgttcttatggaagccgggaa ggatctgtatcaagccgttctggagagtgcagtcctgttcctatgggttcatttccaaga agagggtttgtaaatggaagcagagaaagtactggatatttagaagaacttgagaaagag aggtcattgcttcttgctgatcttgacaaagaagaaaaggaaaaagactggtattacgct caacttcagaatctcactaaaagaatagatagtcttcctttaactgaaaatttttcctta caaacagatatgaccagaaggcaattggaatatgaagcaaggcaaatcagagttgcgatg gaagaacaactaggtacctgccaggatatggaaaaacgagcacagcgaagaatagccaga attcagcaaatcgaaaaggacatacttcgtatacgacagcttttacagtcccaagcaaca gaagcagagaggtcatctcagaacaagcatgaaaccggctcacatgatgctgagcggcag aatgaaggtcaaggagtgggagaaatcaacatggcaacttctggtaatggtcagggttca actacacgaatggaccatgaaacagccagtgttttgagttctagtagcacacactctgca cctcgaaggctgacaagtcatctgggaaccaaggtggaaatggtgtattcattgttgtca atgcttggtactcatgataaggatgatatgtcgcgaactttgctagctatgtctagctcc caagacagctgtatatccatgcgacagtctggatgtcttcctctcctcatccagctttta catggcaatgacaaagactctgtattgttgggaaattcccggggcagtaaagaggctcgg gccagggccagtgcagcactccacaacatcattcactcacagcctgatgacaagagaggc aggcgtgaaatccgagtccttcatcttttggaacagatacgcgcttactgtgaaacctgt tgggagtggcaggaagctcatgaaccaggcatggaccaggacaaaaatccaatgccagct cctgttgaacatcagatctgtcctgctgtgtgtgttctaatgaaactttcatttgatgaa gagcatagacatgcaatgaatgaactagggggactacaggccattgcagaattattgcaa gtggactgtgaaatgtatgggcttactaatgaccactacagtattacactaagacgatat gctggaatggctttgacaaacttgacttttggagatgtagccaacaaggctacgctatgc tctatgaaaggctgcatgagagcacttgtggcccaactaaaatctgaaagtgaagactta cagcaggttattgcgagtgttttgaggaatttgtcttggcgagcagatgtaaatagtaaa aagacgttgcgagaagttggaagtgtgaaagcattgatggaatgtgctttagaagttaaa aaggaatcaaccctcaaaagcgtattgagtgccttatggaatttgtcagcacattgcact gagaataaagctgatatatgtgctgtagatggtgcacttgcatttttggttggcactctt acttaccggagccagacaaacactttagccattattgaaagtggaggtgggatattacgg aatgtgtccagcttgatagctacaaatgaggaccacaggcaaatcctaagagagaacaac tgtctacaaactttattacaacacttaaaatctcatagtttgacaatagtcagtaatgca tgtggaactttgtggaatctctcagcaagaaatcctaaagaccaggaagcattatgggac atgggggcagttagcatgctcaagaacctcattcattcaaagcacaaaatgattgctatg ggaagtgctgcagctttaaggaatctcatggcaaataggcctgcgaagtacaaggatgcc aatattatgtctcctggctcaagcttgccatctcttcatgttaggaaacaaaaagcccta gaagcagaattagatgctcagcacttatcagaaacttttgacaatatagacaatttaagt cccaaggcatctcatcgtagtaagcagagacacaagcaaagtctctatggtgattatgtt tttgacaccaatcgacatgatgataataggtcagacaattttaatactggcaacatgact gtcctttcaccatatttgaatactacagtgttacccagctcctcttcatcaagaggaagc ttagatagttctcgttctgaaaaagatagaagtttggagagagaacgcggaattggtcta ggcaactaccatccagcaacagaaaatccaggaacttcttcaaagcgaggtttgcagatc tccaccactgcagcccagattgccaaagtcatggaagaagtgtcagccattcatacctct caggaagacagaagttctgggtctaccactgaattacattgtgtgacagatgagagaaat gcacttagaagaagctctgctgcccatacacattcaaacacttacaatttcactaagtcg gaaaattcaaataggacatgttctatgccttatgccaaattagaatacaagagatcttca aatgatagtttaaatagtgtcagtagtagtgatggttatggtaaaagaggtcaaatgaaa ccctcgattgaatcctattctgaagatgatgaaagtaagttttgcagttatggtcaatac ccagccgacctagcccataaaatacatagtgcaaatcatatggatgataatgatggagaa ctagatacaccaataaattatagtcttaaatattcagatgagcagttgaactctggaagg caaagtccttcacagaatgaaagatgggcaagacccaaacacataatagaagatgaaata aaacaaagtgagcaaagacaatcaaggaatcaaagtacaacttatcctgtttatactgag agcactgatgataaacacctcaagttccaaccacattttggacagcaggaatgtgtttct ccatacaggtcacggggagccaatggttcagaaacaaatcgagtgggttctaatcatgga attaatcaaaatgtaagccagtctttgtgtcaagaagatgactatgaagatgataagcct accaattatagtgaacgttactctgaagaagaacagcatgaagaagaagagagaccaaca aattatagcataaaatataatgaagagaaacgtcatgtggatcagcctattgattatagt ttaaaatatgccacagatattccttcatcacagaaacagtcattttcattctcaaagagt tcatctggacaaagcagtaaaaccgaacatatgtcttcaagcagtgagaatacgtccaca ccttcatctaatgccaagaggcagaatcagctccatccaagttctgcacagagtagaagt ggtcagcctcaaaaggctgccacttgcaaagtttcttctattaaccaagaaacaatacag acttattgtgtagaagatactccaatatgtttttcaagatgtagttcattatcatctttg tcatcagctgaagatgaaataggatgtaatcagacgacacaggaagcagattctgctaat accctgcaaatagcagaaataaaagaaaagattggaactaggtcagctgaagatcctgtg agcgaagttccagcagtgtcacagcaccctagaaccaaatccagcagactgcagggttct agtttatcttcagaatcagccaggcacaaagctgttgaattttcttcaggagcgaaatct ccctccaaaagtggtgctcagacacccaaaagtccacctgaacactatgttcaggagacc ccactcatgtttagcagatgtacttctgtcagttcacttgatagttttgagagtcgttcg attgccagctccgttcagagtgaaccatgcagtggaatggtaagtggcattataagcccc agtgatcttccagatagccctggacaaaccatgccaccaagcagaagtaaaacacctcca ccacctcctcaaacagctcaaaccaagcgagaagtacctaaaaataaagcacctactgct gaaaagagagagagtggacctaagcaagctgcagtaaatgctgcagttcagagggtccag gttcttccagatgctgatactttattacattttgccacggaaagtactccagatggattt tcttgttcatccagcctgagtgctctgagcctcgatgagccatttatacagaaagatgtg gaattaagaataatgcctccagttcaggaaaatgacaatgggaatgaaacagaatcagag cagcctaaagaatcaaatgaaaaccaagagaaagaggcagaaaaaactattgattctgaa aaggacctattagatgattcagatgatgatgatattgaaatactagaagaatgtattatt tctgccatgccaacaaagtcatcacgtaaagcaaaaaagccagcccagactgcttcaaaa ttacctccacctgtggcaaggaaaccaagtcagctgcctgtgtacaaacttctaccatca caaaacaggttgcaaccccaaaagcatgttagttttacaccgggggatgatatgccacgg gtgtattgtgttgaagggacacctataaacttttccacagctacatctctaagtgatcta acaatcgaatcccctccaaatgagttagctgctggagaaggagttagaggaggggcacag tcaggtgaatttgaaaaacgagataccattcctacagaaggcagaagtacagatgaggct caaggaggaaaaacctcatctgtaaccatacctgaattggatgacaataaagcagaggaa ggtgatattcttgcagaatgcattaattctgctatgcccaaagggaaaagtcacaagcct ttccgtgtgaaaaagataatggaccaggtccagcaagcatctgcgtcttcttctgcaccc aacaaaaatcagttagatggtaagaaaaagaaaccaacttcaccagtaaaacctatacca caaaatactgaatataggacacgtgtaagaaaaaatgcagactcaaaaaataatttaaat gctgagagagttttctcagacaacaaagattcaaagaaacagaatttgaaaaataattcc aaggtcttcaatgataagctcccaaataatgaagatagagtcagaggaagttttgctttt gattcacctcatcattacacgcctattgaaggaactccttactgtttttcacgaaatgat tctttgagttctctagattttgatgatgatgatgttgacctttccagggaaaaggctgaa ttaagaaaggcaaaagaaaataaggaatcagaggctaaagttaccagccacacagaacta acctccaaccaacaatcagctaataagacacaagctattgcaaagcagccaataaatcga ggtcagcctaaacccatacttcagaaacaatccacttttccccagtcatccaaagacata ccagacagaggggcagcaactgatgaaaagttacagaattttgctattgaaaatactccg gtttgcttttctcataattcctctctgagttctctcagtgacattgaccaagaaaacaac aataaagaaaatgaacctatcaaagagactgagccccctgactcacagggagaaccaagt aaacctcaagcatcaggctatgctcctaaatcatttcatgttgaagataccccagtttgt ttctcaagaaacagttctctcagttctcttagtattgactctgaagatgacctgttgcag gaatgtataagctccgcaatgccaaaaaagaaaaagccttcaagactcaagggtgataat gaaaaacatagtcccagaaatatgggtggcatattaggtgaagatctgacacttgatttg aaagatatacagagaccagattcagaacatggtctatcccctgattcagaaaattttgat tggaaagctattcaggaaggtgcaaattccatagtaagtagtttacatcaagctgctgct gctgcatgtttatctagacaagcttcgtctgattcagattccatcctttccctgaaatca ggaatctctctgggatcaccatttcatcttacacctgatcaagaagaaaaaccctttaca agtaataaaggcccacgaattctaaaaccaggggagaaaagtacattggaaactaaaaag atagaatctgaaagtaaaggaatcaaaggaggaaaaaaagtttataaaagtttgattact ggaaaagttcgatctaattcagaaatttcaggccaaatgaaacagccccttcaagcaaac atgccttcaatctctcgaggcaggacaatgattcatattccaggagttcgaaatagctcc tcaagtacaagtcctgtttctaaaaaaggcccaccccttaagactccagcctccaaaagc cctagtgaaggtcaaacagccaccacttctcctagaggagccaagccatctgtgaaatca gaattaagccctgttgccaggcagacatcccaaataggtgggtcaagtaaagcaccttct agatcaggatctagagattcgaccccttcaagacctgcccagcaaccattaagtagacct atacagtctcctggccgaaactcaatttcccctggtagaaatggaataagtcctcctaac aaattatctcaacttccaaggacatcatcccctagtactgcttcaactaagtcctcaggt tctggaaaaatgtcatatacatctccaggtagacagatgagccaacagaaccttaccaaa caaacaggtttatccaagaatgccagtagtattccaagaagtgagtctgcctccaaagga ctaaatcagatgaataatggtaatggagccaataaaaaggtagaactttctagaatgtct tcaactaaatcaagtggaagtgaatctgatagatcagaaagacctgtattagtacgccag tcaactttcatcaaagaagctccaagcccaaccttaagaagaaaattggaggaatctgct tcatttgaatctctttctccatcatctagaccagcttctcccactaggtcccaggcacaa actccagttttaagtccttcccttcctgatatgtctctatccacacattcgtctgttcag gctggtggatggcgaaaactcccacctaatctcagtcccactatagagtataatgatgga agaccagcaaagcgccatgatattgcacggtctcattctgaaagtccttctagacttcca atcaataggtcaggaacctggaaacgtgagcacagcaaacattcatcatcccttcctcga gtaagcacttggagaagaactggaagttcatcttcaattctttctgcttcatcagaatcc agtgaaaaagcaaaaagtgaggatgaaaaacatgtgaactctatttcaggaaccaaacaa agtaaagaaaaccaagtatccgcaaaaggaacatggagaaaaataaaagaaaatgaattt tctcccacaaatagtacttctcagaccgtttcctcaggtgctacaaatggtgctgaatca aagactctaatttatcaaatggcacctgctgtttctaaaacagaggatgtttgggtgaga attgaggactgtcccattaacaatcctagatctggaagatctcccacaggtaatactccc ccggtgattgacagtgtttcagaaaaggcaaatccaaacattaaagattcaaaagataat caggcaaaacaaaatgtgggtaatggcagtgttcccatgcgtaccgtgggtttggaaaat cgcctgaactcctttattcaggtggatgcccctgaccaaaaaggaactgagataaaacca ggacaaaataatcctgtccctgtatcagagactaatgaaagttctatagtggaacgtacc ccattcagttctagcagctcaagcaaacacagttcacctagtgggactgttgctgccaga gtgactccttttaattacaacccaagccctaggaaaagcagcgcagatagcacttcagct cggccatctcagatcccaactccagtgaataacaacacaaagaagcgagattccaaaact gacagcacagaatccagtggaacccaaagtcctaagcgccattctgggtcttaccttgtg acatctgtttaa |
Protein Sequence |
>324 : length: 2843 MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAM ASSGQIDLLERLKELNLDSSNFPGVKLRSKMSLRSYGSREGSVSSRSGECSPVPMGSFPR RGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL QTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQAT EAERSSQNKHETGSHDAERQNEGQGVGEINMATSGNGQGSTTRMDHETASVLSSSSTHSA PRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLL HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETC WEWQEAHEPGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAMNELGGLQAIAELLQ VDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDL QQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCT ENKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENN CLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIHSKHKMIAM GSAAALRNLMANRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLS PKASHRSKQRHKQSLYGDYVFDTNRHDDNRSDNFNTGNMTVLSPYLNTTVLPSSSSSRGS LDSSRSEKDRSLERERGIGLGNYHPATENPGTSSKRGLQISTTAAQIAKVMEEVSAIHTS QEDRSSGSTTELHCVTDERNALRRSSAAHTHSNTYNFTKSENSNRTCSMPYAKLEYKRSS NDSLNSVSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDGE LDTPINYSLKYSDEQLNSGRQSPSQNERWARPKHIIEDEIKQSEQRQSRNQSTTYPVYTE STDDKHLKFQPHFGQQECVSPYRSRGANGSETNRVGSNHGINQNVSQSLCQEDDYEDDKP TNYSERYSEEEQHEEEERPTNYSIKYNEEKRHVDQPIDYSLKYATDIPSSQKQSFSFSKS SSGQSSKTEHMSSSSENTSTPSSNAKRQNQLHPSSAQSRSGQPQKAATCKVSSINQETIQ TYCVEDTPICFSRCSSLSSLSSAEDEIGCNQTTQEADSANTLQIAEIKEKIGTRSAEDPV SEVPAVSQHPRTKSSRLQGSSLSSESARHKAVEFSSGAKSPSKSGAQTPKSPPEHYVQET PLMFSRCTSVSSLDSFESRSIASSVQSEPCSGMVSGIISPSDLPDSPGQTMPPSRSKTPP PPPQTAQTKREVPKNKAPTAEKRESGPKQAAVNAAVQRVQVLPDADTLLHFATESTPDGF SCSSSLSALSLDEPFIQKDVELRIMPPVQENDNGNETESEQPKESNENQEKEAEKTIDSE KDLLDDSDDDDIEILEECIISAMPTKSSRKAKKPAQTASKLPPPVARKPSQLPVYKLLPS QNRLQPQKHVSFTPGDDMPRVYCVEGTPINFSTATSLSDLTIESPPNELAAGEGVRGGAQ SGEFEKRDTIPTEGRSTDEAQGGKTSSVTIPELDDNKAEEGDILAECINSAMPKGKSHKP FRVKKIMDQVQQASASSSAPNKNQLDGKKKKPTSPVKPIPQNTEYRTRVRKNADSKNNLN AERVFSDNKDSKKQNLKNNSKVFNDKLPNNEDRVRGSFAFDSPHHYTPIEGTPYCFSRND SLSSLDFDDDDVDLSREKAELRKAKENKESEAKVTSHTELTSNQQSANKTQAIAKQPINR GQPKPILQKQSTFPQSSKDIPDRGAATDEKLQNFAIENTPVCFSHNSSLSSLSDIDQENN NKENEPIKETEPPDSQGEPSKPQASGYAPKSFHVEDTPVCFSRNSSLSSLSIDSEDDLLQ ECISSAMPKKKKPSRLKGDNEKHSPRNMGGILGEDLTLDLKDIQRPDSEHGLSPDSENFD WKAIQEGANSIVSSLHQAAAAACLSRQASSDSDSILSLKSGISLGSPFHLTPDQEEKPFT SNKGPRILKPGEKSTLETKKIESESKGIKGGKKVYKSLITGKVRSNSEISGQMKQPLQAN MPSISRGRTMIHIPGVRNSSSSTSPVSKKGPPLKTPASKSPSEGQTATTSPRGAKPSVKS ELSPVARQTSQIGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGRNSISPGRNGISPPN KLSQLPRTSSPSTASTKSSGSGKMSYTSPGRQMSQQNLTKQTGLSKNASSIPRSESASKG LNQMNNGNGANKKVELSRMSSTKSSGSESDRSERPVLVRQSTFIKEAPSPTLRRKLEESA SFESLSPSSRPASPTRSQAQTPVLSPSLPDMSLSTHSSVQAGGWRKLPPNLSPTIEYNDG RPAKRHDIARSHSESPSRLPINRSGTWKREHSKHSSSLPRVSTWRRTGSSSSILSASSES SEKAKSEDEKHVNSISGTKQSKENQVSAKGTWRKIKENEFSPTNSTSQTVSSGATNGAES KTLIYQMAPAVSKTEDVWVRIEDCPINNPRSGRSPTGNTPPVIDSVSEKANPNIKDSKDN QAKQNVGNGSVPMRTVGLENRLNSFIQVDAPDQKGTEIKPGQNNPVPVSETNESSIVERT PFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNTKKRDSKT DSTESSGTQSPKRHSGSYLVTSV |