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| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 324 |
Name | APC |
Synonymous | BTPS2|DP2|DP2.5|DP3|GS|PPP1R46;adenomatous polyposis coli;APC;adenomatous polyposis coli |
Definition | adenomatosis polyposis coli tumor suppressor|adenomatous polyposis coli protein|deleted in polyposis 2.5|protein phosphatase 1, regulatory subunit 46 |
Position | 5q21-q22 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
|
Regulation From TransFac database |
apc(h) + beta-catenin(h) <==> apc(h):beta-catenin(h) (binding) | beta-catenin(h) + apc(h) + alpha-catenin1(m) <==> alpha-catenin1(m):beta-catenin(h):apc(h) (binding) | apc(h) + axin(h) + beta-catenin(h) <==> apc(h):axin(h):beta-catenin(h) (binding) | apc(h) + conductin(m) <==> apc(h):conductin(m) (binding) | apc(h) + axin(h) <==> apc(h):axin(h) (binding) | apc(h) + axin(r) + ATP --GSK3beta(r)--> apc(h){p} + axin(r) + ADP (phosphorylation; competition) | apc(h) + axin(m) + GSK3beta(h) <==> apc(h):axin(m):GSK3beta(h) (binding) | alpha-catenin1(h) + apc(h) + beta-catenin(h) + plakoglobin(h) <==> alpha-catenin1(h):apc(h):beta-catenin(h):plakoglobin(h) (binding) | apc(h) + beta-catenin(m) <==> apc(h):beta-catenin(m) (binding) | apc(h) + axin(h) + beta-catenin(h) + GSK3beta(h) <==> apc(h):axin(h):beta-catenin(h):GSK3beta(h) (binding) | apc(h) + axin(r) + beta-TrCP1(m) <==> apc(h):axin(r):beta-TrCP1(m) (binding) | apc(h) + beta-catenin(h) + beta-TrCP1(h) <==> apc(h):beta-catenin(h):beta-TrCP1(h) (binding) | apc(h) + Siah1(h) <==> apc(h):Siah1(h) (binding) | B56alpha(h) + apc(h) <==> apc(h):B56alpha(h) (binding) | B56beta(h) + apc(h) <==> apc(h):B56beta(h) (binding) | B56delta(h) + apc(h) <==> apc(h):B56delta(h) (binding) | B56gamma(h) + apc(h) <==> apc(h):B56gamma(h) (binding) | apc(h) + ATP --CKI-delta(r)--> apc(h){p} + ADP (phosphorylation) | Smad7(m.s.) + axin(m.s.) + GSK3beta(h) + beta-catenin(h) + apc(h) + CKI(h) <==> Smad7(m.s.):axin(m.s.):GSK3beta(h):beta-catenin(h):apc(h):CKI(h) (binding) | 14-3-3sigma(m.s.) + apc(h) <==> 14-3-3sigma(m.s.):apc(h) (binding) | APC(h) --> apc(h) (expression). | APC(h) --> apc(h) (expression). | APC(h) --> APC(h) (expression). | hsa-miR-135a --/ APC(h) (increase of mRNA decay). | hsa-miR-135b --/ APC(h) (increase of mRNA decay). |
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Post Transcriptional Modification From dbPTM | | Top | |
|
Location (AA) |
PTM type |
Literature |
Database |
1038 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 1180 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 1371 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 1697 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 1861 | Phosphoserine. | Swiss-Prot 53.0 | 1863 | Phosphoserine. | Swiss-Prot 53.0 | 1864 | Phosphoserine. | Swiss-Prot 53.0 | 2283 | Phosphoserine. | Swiss-Prot 53.0 | 2398 | Phosphoserine. | Swiss-Prot 53.0 | 2674 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 2710 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 1279 | Phosphoserine (CK1 epsilon;) | 11487578 | Phospho.ELM 6.0 | 1392 | Phosphoserine (CK1 epsilon;) | 11487578 | Phospho.ELM 6.0 | 1861 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1863 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1864 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 2398 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 2034 | Phosphoserine | 11689703 | Phospho.ELM 6.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
|
Chromosome |
Location |
Source |
|---|---|---|
chr5 |
Promoter: 112099983 - 112101983 | GoldenGate_Methylation_Cancer_Panel_I |
chr5 |
Promoter: 112099983 - 112101983 | GSE27584 |
chr5 |
Promoter: 112099983 - 112101983 | Agilent_014791_44K |
chr5 |
Promoter: 112099983 - 112101983 | PMID:20563638 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15526363 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15326380 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:16207479 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15386372 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15375009 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15760919 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15122305 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15389252 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:12970888 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:14719065 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15087381 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:16902913 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:17378912 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:16336454 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15476557 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:16598760 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:16870044 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:12841866 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:11448917 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15042681 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:12684406 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:16043258 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:16644104 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:12467239 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:11429699 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:11895880 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:16452191 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15639718 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15073103 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15758578 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:16075282 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:10951570 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:17369979 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:16163424 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:16619216 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15197775 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15942635 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:12695555 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:12746473 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:14675710 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:16956712 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15026333 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:14743506 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15623627 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15292941 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:11839671 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15930345 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:17070312 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:16170165 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:17363525 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:17139617 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:16446401 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15448006 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:17222366 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15788661 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15508191 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15328171 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15671542 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15172987 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:11437404 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15543763 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:12800196 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:12937151 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15897561 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:14507645 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:16565510 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15467712 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:12213730 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:16331610 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:11448914 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15589597 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15713962 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:12773202 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15217927 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15289362 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:16278815 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:16407829 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:11078757 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15041703 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:17017434 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:16849682 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15154012 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:16775427 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:17177027 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:16061849 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:12429618 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:16537562 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:12584167 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:14501508 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15447999 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:16699861 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:14527906 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:16166431 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:16928264 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:12097272 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15361208 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15153437 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:16858687 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:12082624 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15133491 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:15641992 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:16785414 |
chr5 |
Promoter: 112099983 - 112101983 | PMID:12545168 |