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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 3248 |
Name | HPGD |
Synonym | 15-PGDH|PGDH|PGDH1|SDR36C1;hydroxyprostaglandin dehydrogenase 15-(NAD);HPGD;hydroxyprostaglandin dehydrogenase 15-(NAD) |
Definition | 15-hydroxyprostaglandin dehydrogenase [NAD+]|NAD+-dependent 15-hydroxyprostaglandin dehydrogenase|prostaglandin dehydrogenase 1|short chain dehydrogenase/reductase family 36C, member 1 |
Position | 4q34-q35 |
Gene Type | protein-coding |
Source | Count: 2; Generif,UniProt |
Literature support | Count: 3 PubMed records as below. |
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Evidence Status |
Description |
reviewed | Demonstrate both downregulation and a tumor suppressor activity of 15-PGDH in gastric cancer. |
potential | Results demonstrate that 15-PGDH acts as a tumor suppressor in gastric cancer and provide further validation for 15-PGDH as a potential therapeutic target for gastric cancer. |
reviewed | 15-PGDH is a direct downstream effector of HNF3beta and acts as a tumor suppressor in lung cancer. |
| More detail of all 3 literatures about HPGD | |
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External Links |
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Links to Entrez Gene | 3248 |
Links to all GeneRIF Items | 3248 |
Links to iHOP | 3248 |
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Sequence Information |
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Nucleotide Sequence |
>3248 : length: 801 atgcacgtgaacggcaaagtggcgctggtgaccggcgcggctcagggcataggcagagcc tttgcagaggcgctgctgcttaagggcgccaaggtagcgctggtggattggaatcttgaa gcaggtgtacagtgtaaagctgccctggatgagcagtttgaacctcagaagactctgttc atccagtgcgatgtggctgaccagcaacaactgagagacacttttagaaaagttgtagac cactttggaagactggacattttggtcaataatgctggagtgaataatgagaaaaactgg gaaaaaactctgcaaattaatttggtttctgttatcagtggaacctatcttggtttggat tacatgagtaagcaaaatggaggtgaaggcggcatcattatcaatatgtcatctttagca ggactcatgcccgttgcacagcagccggtttattgtgcttcaaagcatggcatagttgga ttcacacgctcagcagcgttggctgctaatcttatgaacagtggtgtgagactgaatgcc atttgtccaggctttgttaacacagccatccttgaatcaattgaaaaagaagaaaacatg ggacaatatatagaatataaggatcatatcaaggatatgattaaatactatggaattttg gacccaccattgattgccaatggattgataacactcattgaagatgatgctttaaatggt gctattatgaagatcacaacttctaagggaattcattttcaagactatgatacaactcca tttcaagcaaaaacccaatga |
Protein Sequence |
>3248 : length: 266 MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLF IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLD YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNA ICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNG AIMKITTSKGIHFQDYDTTPFQAKTQ |