Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

3487

Name

IGFBP4

Synonym

BP-4|HT29-IGFBP|IBP4|IGFBP-4;insulin-like growth factor binding protein 4;IGFBP4;insulin-like growth factor binding protein 4

Definition

IBP-4|IGF-binding protein 4|insulin-like growth factor-binding protein 4

Position

17q12-q21.1

Gene Type

protein-coding

Source

Count: 1; Generif

Literature support

Count: 1 PubMed records as below.

Evidence Status

Description

potential

conclusion: decreased IGFBP-4 tumor expression might be a step in the progression from primary to metastatic melanoma; data lend support to a recently-described novel tumor suppressor role of secreting IGFBPs in melanoma.
More detail of all 1 literatures about IGFBP4

Pathways and Diseases

Pathway

Wnt signaling network;PID Curated;200055

Pathway

Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs);PID Reactome;500133

Pathway

Diabetes pathways;Reactome;REACT:15380

Disease

Cancer;FunDO

External Links

Links to Entrez Gene

3487

Links to all GeneRIF Items

3487

Links to iHOP

3487

Sequence Information

Nucleotide Sequence

>3487 : length: 777
atgctgcccctctgcctcgtggccgccctgctgctggccgccgggcccgggccgagcctg
ggcgacgaagccatccactgcccgccctgctccgaggagaagctggcgcgctgccgcccc
cccgtgggctgcgaggagctggtgcgagagccgggctgcggctgttgcgccacttgcgcc
ctgggcttggggatgccctgcggggtgtacaccccccgttgcggctcgggcctgcgctgc
tacccgccccgaggggtggagaagcccctgcacacactgatgcacgggcaaggcgtgtgc
atggagctggcggagatcgaggccatccaggaaagcctgcagccctctgacaaggacgag
ggtgaccaccccaacaacagcttcagcccctgtagcgcccatgaccgcaggtgcctgcag
aagcacttcgccaaaattcgagaccggagcaccagtgggggcaagatgaaggtcaatggg
gcgccccgggaggatgcccggcctgtgccccagggctcctgccagagcgagctgcaccgg
gcgctggagcggctggccgcttcacagagccgcacccacgaggacctctacatcatcccc
atccccaactgcgaccgcaacggcaacttccaccccaagcagtgtcacccagctctggat
gggcagcgtggcaagtgctggtgtgtggaccggaagacgggggtgaagcttccggggggc
ctggagccaaagggggagctggactgccaccagctggctgacagctttcgagagtga

Protein Sequence

>3487 : length: 258
MLPLCLVAALLLAAGPGPSLGDEAIHCPPCSEEKLARCRPPVGCEELVREPGCGCCATCA
LGLGMPCGVYTPRCGSGLRCYPPRGVEKPLHTLMHGQGVCMELAEIEAIQESLQPSDKDE
GDHPNNSFSPCSAHDRRCLQKHFAKIRDRSTSGGKMKVNGAPREDARPVPQGSCQSELHR
ALERLAASQSRTHEDLYIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKLPGG
LEPKGELDCHQLADSFRE



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