Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

3487

Name

IGFBP4

Synonymous

BP-4|HT29-IGFBP|IBP4|IGFBP-4;insulin-like growth factor binding protein 4;IGFBP4;insulin-like growth factor binding protein 4

Definition

IBP-4|IGF-binding protein 4|insulin-like growth factor-binding protein 4

Position

17q12-q21.1

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors

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Regulation From TransFac database

IGFBP-4(h) + HKII(r) <==> IGFBP-4(h):HKII(r) (binding)
HKIII(r) + IGFBP-4(h) <==> HKIII(r):IGFBP-4(h) (binding)
IGF-1(h) + IGFBP-4(h) <==> IGF-1(h):IGFBP-4(h) (binding)
IGF-2(m.s.) + IGFBP-4(h) <==> IGF-2(m.s.):IGFBP-4(h) (binding)
IGF-2(h) + IGFBP-4(h) <==> IGF-2(h):IGFBP-4(h) (binding)
IGF-2(h) + IGFBP-4(h) <==> IGF-2(h):IGFBP-4(h) (binding)
IGFBP-4(h) --PAPP-A(h)--> protein remnants (cleavage)
IGFBP-4(h) --kallikrein-2(h)--> IGFBP4-p21(h) + protein remnants (cleavage)
IGFBP-4(h) --kallikrein-2(h)--> IGFBP4-p10(h) + protein remnants (cleavage)
IGFBP-4(h) --kallikrein-3(h)--> IGFBP4-p26(h) + protein remnants (cleavage)
IGFBP-4(h) --kallikrein-3(h)--> IGFBP4-p21(h) + protein remnants (cleavage)
TSP-1(h) + IGFBP-4(h) <==> TSP-1(h):IGFBP-4(h) (binding)
IGFBP4(h) --> IGFBP-4(h) (expression).
IGF-2(h) + IGFBP-4(h) <==> IGF-2(h):IGFBP-4(h) (binding)
IGF-1(h) + IGFBP-4(h) <==> IGF-1(h):IGFBP-4(h) (binding)
IGFBP4(h) --> IGFBP-4(h) (expression).

Post Transcriptional Modification From dbPTM

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Location (AA)

PTM type

Literature

Database

125N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0

Methylation Profile From DiseaseMeth database

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Chromosome

Location

Source

chr17

Promoter: 35851702 - 35853702Agilent_014791

chr17

Promoter: 35851702 - 35853702GSE27584

chr17

Promoter: 35851702 - 35853702Agilent_014791_44K

chr17

Promoter: 35851702 - 35853702Agilent_014791


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