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| General information | Expression | Regulation | Mutation | Interaction |
Basic Information | |
|---|---|
Gene ID | 3487 |
Name | IGFBP4 |
Synonymous | BP-4|HT29-IGFBP|IBP4|IGFBP-4;insulin-like growth factor binding protein 4;IGFBP4;insulin-like growth factor binding protein 4 |
Definition | IBP-4|IGF-binding protein 4|insulin-like growth factor-binding protein 4 |
Position | 17q12-q21.1 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
Regulation From TransFac database | IGFBP-4(h) + HKII(r) <==> IGFBP-4(h):HKII(r) (binding) | HKIII(r) + IGFBP-4(h) <==> HKIII(r):IGFBP-4(h) (binding) | IGF-1(h) + IGFBP-4(h) <==> IGF-1(h):IGFBP-4(h) (binding) | IGF-2(m.s.) + IGFBP-4(h) <==> IGF-2(m.s.):IGFBP-4(h) (binding) | IGF-2(h) + IGFBP-4(h) <==> IGF-2(h):IGFBP-4(h) (binding) | IGF-2(h) + IGFBP-4(h) <==> IGF-2(h):IGFBP-4(h) (binding) | IGFBP-4(h) --PAPP-A(h)--> protein remnants (cleavage) | IGFBP-4(h) --kallikrein-2(h)--> IGFBP4-p21(h) + protein remnants (cleavage) | IGFBP-4(h) --kallikrein-2(h)--> IGFBP4-p10(h) + protein remnants (cleavage) | IGFBP-4(h) --kallikrein-3(h)--> IGFBP4-p26(h) + protein remnants (cleavage) | IGFBP-4(h) --kallikrein-3(h)--> IGFBP4-p21(h) + protein remnants (cleavage) | TSP-1(h) + IGFBP-4(h) <==> TSP-1(h):IGFBP-4(h) (binding) | IGFBP4(h) --> IGFBP-4(h) (expression). | IGF-2(h) + IGFBP-4(h) <==> IGF-2(h):IGFBP-4(h) (binding) | IGF-1(h) + IGFBP-4(h) <==> IGF-1(h):IGFBP-4(h) (binding) | IGFBP4(h) --> IGFBP-4(h) (expression). |
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Post Transcriptional Modification From dbPTM | | Top | |
Location (AA) | PTM type | Literature | Database | 125 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
Chromosome | Location | Source |
|---|---|---|
chr17 |
Promoter: 35851702 - 35853702 | Agilent_014791 |
chr17 |
Promoter: 35851702 - 35853702 | GSE27584 |
chr17 |
Promoter: 35851702 - 35853702 | Agilent_014791_44K |
chr17 |
Promoter: 35851702 - 35853702 | Agilent_014791 |
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