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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 3685 |
Name | ITGAV |
Synonym | CD51|MSK8|VNRA;integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51);ITGAV;integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) |
Definition | antigen identified by monoclonal antibody L230|integrin alpha-V|vitronectin receptor subunit alpha |
Position | 2q31-q32 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 2 PubMed records as below. |
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Evidence Status |
Description |
potential | This study shows that alpha(v)beta(3)-integrin expression on tumor cells actually slows tumor progression and acts as a tumor suppressor. |
potential | alphav integrins play a tumor suppressor-like function. |
| More detail of all 2 literatures about ITGAV | |
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Pathways and Diseases |
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Pathway | Small cell lung cancer;KEGG PATHWAY;hsa05222 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810 |
Pathway | Signaling events mediated by VEGFR1 and VEGFR2;PID Curated;200161 |
Pathway | Cell adhesion molecules (CAMs);KEGG PATHWAY;hsa04514 |
Pathway | ECM-receptor interaction;KEGG PATHWAY;hsa04512 |
Pathway | PDGFR-alpha signaling pathway;PID Curated;200140 |
Pathway | Integrin cell surface interactions;Reactome;REACT:13552 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | PECAM1 interactions;PID Reactome;500307 |
Pathway | Integrin cell surface interactions;PID Reactome;500004 |
Pathway | Osteopontin-mediated events;PID Curated;200042 |
Pathway | Nectin adhesion pathway;PID Curated;200053 |
Pathway | Hypertrophic cardiomyopathy (HCM);KEGG PATHWAY;hsa05410 |
Pathway | Signaling events mediated by focal adhesion kinase;PID Curated;200192 |
Pathway | Arrhythmogenic right ventricular cardiomyopathy (ARVC);KEGG PATHWAY;hsa05412 |
Pathway | Integrin signalling pathway;PANTHER;P00034 |
Pathway | phospholipids as signalling intermediaries;PID BioCarta;100183 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Phagosome;KEGG PATHWAY;hsa04145 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Integrins in angiogenesis;PID Curated;200109 |
Pathway | Dilated cardiomyopathy;KEGG PATHWAY;hsa05414 |
Disease | Drug abuse;FunDO |
Disease | Herpes;FunDO |
Disease | Pleural effusion, Malignant;FunDO |
Disease | IMMUNE;GAD |
Disease | Rheumatoid arthritis;FunDO |
Disease | Cancer;FunDO |
Disease | rheumatoid arthritis;GAD |
Disease | Alzheimer's disease;FunDO |
Disease | Atherosclerosis;FunDO |
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External Links |
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Links to Entrez Gene | 3685 |
Links to all GeneRIF Items | 3685 |
Links to iHOP | 3685 |
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Sequence Information |
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Nucleotide Sequence |
>3685 : length: 3009 atgctcctaggcaccctccttctgatcctgtacatcttaatgttgtgccggatgtttctt ctcgtgggagctcccaaagcaaacaccacccagcctgggattgtggaaggagggcaggtc ctcaaatgtgactggtcttctacccgccggtgccagccaattgaatttgatgcaacaggc aatagagattatgccaaggatgatccattggaatttaagtcccatcagtggtttggagca tctgtgaggtcgaaacaggataaaattttggcctgtgccccattgtaccattggagaact gagatgaaacaggagcgagagcctgttggaacatgctttcttcaagatggaacaaagact gttgagtatgctccatgtagatcacaagatattgatgctgatggacagggattttgtcaa ggaggattcagcattgattttactaaagctgacagagtacttcttggtggtcctggtagc ttttattggcaaggtcagcttatttcggatcaagtggcagaaatcgtatctaaatacgac cccaatgtttacagcatcaagtataataaccaattagcaactcggactgcacaagctatt tttgatgacagctatttgggttattctgtggctgtcggagatttcaatggtgatggcata gatgactttgtttcaggagttccaagagcagcaaggactttgggaatggtttatatttat gatgggaagaacatgtcctccttatacaattttactggcgagcagatggctgcatatttc ggattttctgtagctgccactgacattaatggagatgattatgcagatgtgtttattgga gcacctctcttcatggatcgtggctctgatggcaaactccaagaggtggggcaggtctca gtgtctctacagagagcttcaggagacttccagacgacaaagctgaatggatttgaggtc tttgcacggtttggcagtgccatagctcctttgggagatctggaccaggatggtttcaat gatattgcaattgctgctccatatgggggtgaagataaaaaaggaattgtttatatcttc aatggaagatcaacaggcttgaacgcagtcccatctcaaatccttgaagggcagtgggct gctcgaagcatgccaccaagctttggctattcaatgaaaggagccacagatatagacaaa aatggatatccagacttaattgtaggagcttttggtgtagatcgagctatcttatacagg gccagaccagttatcactgtaaatgctggtcttgaagtgtaccctagcattttaaatcaa gacaataaaacctgctcactgcctggaacagctctcaaagtttcctgttttaatgttagg ttctgcttaaaggcagatggcaaaggagtacttcccaggaaacttaatttccaggtggaa cttcttttggataaactcaagcaaaagggagcaattcgacgagcactgtttctctacagc aggtccccaagtcactccaagaacatgactatttcaagggggggactgatgcagtgtgag gaattgatagcgtatctgcgggatgaatctgaatttagagacaaactcactccaattact atttttatggaatatcggttggattatagaacagctgctgatacaacaggcttgcaaccc attcttaaccagttcacgcctgctaacattagtcgacaggctcacattctacttgactgt ggtgaagacaatgtctgtaaacccaagctggaagtttctgtagatagtgatcaaaagaag atctatattggggatgacaaccctctgacattgattgttaaggctcagaatcaaggagaa ggtgcctacgaagctgagctcatcgtttccattccactgcaggctgatttcatcggggtt gtccgaaacaatgaagccttagcaagactttcctgtgcatttaagacagaaaaccaaact cgccaggtggtatgtgaccttggaaacccaatgaaggctggaactcaactcttagctggt cttcgtttcagtgtgcaccagcagtcagagatggatacttctgtgaaatttgacttacaa atccaaagctcaaatctatttgacaaagtaagcccagttgtatctcacaaagttgatctt gctgttttagctgcagttgagataagaggagtctcgagtcctgatcatatctttcttccg attccaaactgggagcacaaggagaaccctgagactgaagaagatgttgggccagttgtt cagcacatctatgagctgagaaacaatggtccaagttcattcagcaaggcaatgctccat cttcagtggccttacaaatataataataacactctgttgtatatccttcattatgatatt gatggaccaatgaactgcacttcagatatggagatcaaccctttgagaattaagatctca tctttgcaaacaactgaaaagaatgacacggttgccgggcaaggtgagcgggaccatctc atcactaagcgggatcttgccctcagtgaaggagatattcacactttgggttgtggagtt gctcagtgcttgaagattgtctgccaagttgggagattagacagaggaaagagtgcaatc ttgtacgtaaagtcattactgtggactgagacttttatgaataaagaaaatcagaatcat tcctattctctgaagtcgtctgcttcatttaatgtcatagagtttccttataagaatctt ccaattgaggatatcaccaactccacattggttaccactaatgtcacctggggcattcag ccagcgcccatgcctgtgcctgtgtgggtgatcattttagcagttctagcaggattgttg ctactggctgttttggtatttgtaatgtacaggatgggcttttttaaacgggtccggcca cctcaagaagaacaagaaagggagcagcttcaacctcatgaaaatggtgaaggaaactca gaaacttaa |
Protein Sequence |
>3685 : length: 1002 MLLGTLLLILYILMLCRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATG NRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKT VEYAPCRSQDIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYD PNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIY DGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVS VSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIF NGRSTGLNAVPSQILEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYR ARPVITVNAGLEVYPSILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVE LLLDKLKQKGAIRRALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPIT IFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKK IYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVVRNNEALARLSCAFKTENQT RQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDL AVLAAVEIRGVSSPDHIFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLH LQWPYKYNNNTLLYILHYDIDGPMNCTSDMEINPLRIKISSLQTTEKNDTVAGQGERDHL ITKRDLALSEGDIHTLGCGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNH SYSLKSSASFNVIEFPYKNLPIEDITNSTLVTTNVTWGIQPAPMPVPVWVIILAVLAGLL LLAVLVFVMYRMGFFKRVRPPQEEQEREQLQPHENGEGNSET |