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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 3690 |
Name | ITGB3 |
Synonym | BDPLT2|CD61|GP3A|GPIIIa|GT;integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61);ITGB3;integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) |
Definition | integrin beta-3|platelet glycoprotein IIIa|platelet membrane glycoprotein IIIa |
Position | 17q21.32 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 1 PubMed records as below. |
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Evidence Status |
Description |
potential | This study shows that alpha(v)beta(3)-integrin expression on tumor cells actually slows tumor progression and acts as a tumor suppressor. |
| More detail of all 1 literatures about ITGB3 | |
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Pathways and Diseases |
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Pathway | Integrin cell surface interactions;PID Reactome;500004 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | Ephrin B reverse signaling;PID Curated;200173 |
Pathway | Arrhythmogenic right ventricular cardiomyopathy (ARVC);KEGG PATHWAY;hsa05412 |
Pathway | ECM-receptor interaction;KEGG PATHWAY;hsa04512 |
Pathway | Integrin cell surface interactions;Reactome;REACT:13552 |
Pathway | IL4-mediated signaling events;PID Curated;200018 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | PECAM1 interactions;PID Reactome;500307 |
Pathway | Osteopontin-mediated events;PID Curated;200042 |
Pathway | Hematopoietic cell lineage;KEGG PATHWAY;hsa04640 |
Pathway | Nectin adhesion pathway;PID Curated;200053 |
Pathway | Hypertrophic cardiomyopathy (HCM);KEGG PATHWAY;hsa05410 |
Pathway | Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810 |
Pathway | Signaling events mediated by VEGFR1 and VEGFR2;PID Curated;200161 |
Pathway | Blood coagulation;PANTHER;P00011 |
Pathway | Integrin signalling pathway;PANTHER;P00034 |
Pathway | phospholipids as signalling intermediaries;PID BioCarta;100183 |
Pathway | Phagosome;KEGG PATHWAY;hsa04145 |
Pathway | Signaling events mediated by PTP1B;PID Curated;200033 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Integrins in angiogenesis;PID Curated;200109 |
Pathway | Arf6 signaling events;PID Curated;200060 |
Pathway | Dilated cardiomyopathy;KEGG PATHWAY;hsa05414 |
Disease | Lupus erythematosus;FunDO |
Disease | Hematologic diseases;KEGG DISEASE |
Disease | IMMUNE;GAD |
Disease | premature myocardial infarction in men.;GAD |
Disease | HEMATOLOGICAL;GAD |
Disease | double homozygosity for receptor polymorphisms of platelet GPIa and GPIIIa;GAD |
Disease | cardiovascular;GAD |
Disease | kidney cancer;GAD |
Disease | breast cancer;GAD |
Disease | Asthma;FunDO |
Disease | Cancer;FunDO |
Disease | Purpura, Thrombocytopenic, Idiopathic;FunDO |
Disease | allergy;GAD |
Disease | Takayasu's arteritis;FunDO |
Disease | fetal loss, early;GAD |
Disease | hypertension;GAD |
Disease | stroke, ischemic;GAD |
Disease | Resistance in vitro to low-dose aspirin;GAD |
Disease | Circulatory system diseases;KEGG DISEASE |
Disease | Stroke;GAD |
Disease | lung cancer;GAD |
Disease | atherosclerosis, coronary;GAD |
Disease | Thrombocytopenia;FunDO |
Disease | cardiovascular disease;GAD |
Disease | Subarachnoid hemorrhage;FunDO |
Disease | Aplastic anemia;FunDO |
Disease | Asthma;GAD |
Disease | METABOLIC;GAD |
Disease | aspirin resistance;GAD |
Disease | Stroke;FunDO |
Disease | cancer;GAD |
Disease | Autistic disorder;FunDO |
Disease | Intermediate coronary syndrome;FunDO |
Disease | diabetes, type 2;GAD |
Disease | PSYCH;GAD |
Disease | Diabetes mellitus;FunDO |
Disease | heart disease, ischemic;GAD |
Disease | Penile disease;FunDO |
Disease | Autism;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | asthma IgE wheezing;GAD |
Disease | Kidney Failure, Chronic;GAD |
Disease | Allograft rejection;KEGG DISEASE;H00083 |
Disease | CANCER;GAD |
Disease | Myocardial Infarction;GAD |
Disease | Hemorrhagic fevers, Viral;FunDO |
Disease | Hemorrhagic disorder;FunDO |
Disease | neonatal thrombocytopenia;GAD |
Disease | REPRODUCTION;GAD |
Disease | cancer.;GAD |
Disease | lipoprotein;GAD |
Disease | Glanzmann thrombasthenia, type B;OMIM |
Disease | peripheral vascular disease;GAD |
Disease | Increased platelet aggregability;GAD |
Disease | Immune system diseases;KEGG DISEASE |
Disease | Glanzmann thrombasthenia;KEGG DISEASE;H00226 |
Disease | fracture risk;GAD |
Disease | Pemphigoid, Bullous;FunDO |
Disease | Allergies and autoimmune diseases;KEGG DISEASE |
Disease | Glanzmann thrombasthenia;GAD |
Disease | breast cancer ovarian cancer;GAD |
Disease | myocardial infarct;GAD |
Disease | Temporal arteritis;FunDO |
Disease | Atherosclerosis;FunDO |
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External Links |
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Links to Entrez Gene | 3690 |
Links to all GeneRIF Items | 3690 |
Links to iHOP | 3690 |
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Sequence Information |
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Nucleotide Sequence |
>3690 : length: 2367 atgcgagcgcggccgcggccccggccgctctgggcgactgtgctggcgctgggggcgctg gcgggcgttggcgtaggagggcccaacatctgtaccacgcgaggtgtgagctcctgccag cagtgcctggctgtgagccccatgtgtgcctggtgctctgatgaggccctgcctctgggc tcacctcgctgtgacctgaaggagaatctgctgaaggataactgtgccccagaatccatc gagttcccagtgagtgaggcccgagtactagaggacaggcccctcagcgacaagggctct ggagacagctcccaggtcactcaagtcagtccccagaggattgcactccggctccggcca gatgattcgaagaatttctccatccaagtgcggcaggtggaggattaccctgtggacatc tactacttgatggacctgtcttactccatgaaggatgatctgtggagcatccagaacctg ggtaccaagctggccacccagatgcgaaagctcaccagtaacctgcggattggcttcggg gcatttgtggacaagcctgtgtcaccatacatgtatatctccccaccagaggccctcgaa aacccctgctatgatatgaagaccacctgcttgcccatgtttggctacaaacacgtgctg acgctaactgaccaggtgacccgcttcaatgaggaagtgaagaagcagagtgtgtcacgg aaccgagatgccccagagggtggctttgatgccatcatgcaggctacagtctgtgatgaa aagattggctggaggaatgatgcatcccacttgctggtgtttaccactgatgccaagact catatagcattggacggaaggctggcaggcattgtccagcctaatgacgggcagtgtcat gttggtagtgacaatcattactctgcctccactaccatggattatccctctttggggctg atgactgagaagctatcccagaaaaacatcaatttgatctttgcagtgactgaaaatgta gtcaatctctatcagaactatagtgagctcatcccagggaccacagttggggttctgtcc atggattccagcaatgtcctccagctcattgttgatgcttatgggaaaatccgttctaaa gtagagctggaagtgcgtgacctccctgaagagttgtctctatccttcaatgccacctgc ctcaacaatgaggtcatccctggcctcaagtcttgtatgggactcaagattggagacacg gtgagcttcagcattgaggccaaggtgcgaggctgtccccaggagaaggagaagtccttt accataaagcccgtgggcttcaaggacagcctgatcgtccaggtcacctttgattgtgac tgtgcctgccaggcccaagctgaacctaatagccatcgctgcaacaatggcaatgggacc tttgagtgtggggtatgccgttgtgggcctggctggctgggatcccagtgtgagtgctca gaggaggactatcgcccttcccagcaggacgaatgcagcccccgggagggtcagcccgtc tgcagccagcggggcgagtgcctctgtggtcaatgtgtctgccacagcagtgactttggc aagatcacgggcaagtactgcgagtgtgacgacttctcctgtgtccgctacaagggggag atgtgctcaggccatggccagtgcagctgtggggactgcctgtgtgactccgactggacc ggctactactgcaactgtaccacgcgtactgacacctgcatgtccagcaatgggctgctg tgcagcggccgcggcaagtgtgaatgtggcagctgtgtctgtatccagccgggctcctat ggggacacctgtgagaagtgccccacctgcccagatgcctgcacctttaagaaagaatgt gtggagtgtaagaagtttgaccggggagccctacatgacgaaaatacctgcaaccgttac tgccgtgacgagattgagtcagtgaaagagcttaaggacactggcaaggatgcagtgaat tgtacctataagaatgaggatgactgtgtcgtcagattccagtactatgaagattctagt ggaaagtccatcctgtatgtggtagaagagccagagtgtcccaagggccctgacatcctg gtggtcctgctctcagtgatgggggccattctgctcattggccttgccgccctgctcatc tggaaactcctcatcaccatccacgaccgaaaagaattcgctaaatttgaggaagaacgc gccagagcaaaatgggacacagccaacaacccactgtataaagaggccacgtctaccttc accaatatcacgtaccggggcacttaa |
Protein Sequence |
>3690 : length: 788 MRARPRPRPLWATVLALGALAGVGVGGPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLG SPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRP DDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFG AFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSR NRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVQPNDGQCH VGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTVGVLS MDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDT VSFSIEAKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGT FECGVCRCGPGWLGSQCECSEEDYRPSQQDECSPREGQPVCSQRGECLCGQCVCHSSDFG KITGKYCECDDFSCVRYKGEMCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLL CSGRGKCECGSCVCIQPGSYGDTCEKCPTCPDACTFKKECVECKKFDRGALHDENTCNRY CRDEIESVKELKDTGKDAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPECPKGPDIL VVLLSVMGAILLIGLAALLIWKLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTF TNITYRGT |