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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 387 |
Name | RHOA |
Synonym | ARH12|ARHA|RHO12|RHOH12;ras homolog gene family, member A;RHOA;ras homolog gene family, member A |
Definition | Aplysia ras-related homolog 12|h12|oncogene RHO H12|rho cDNA clone 12|small GTP binding protein RhoA|transforming protein RhoA |
Position | 3p21.3 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 2 PubMed records as below. |
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Evidence Status |
Description |
potential | "activation of the RhoA-ROCK-p38MAPK-MSK signaling pathway is essential for the regulation of the phenotype and of the CST5/cystatin D candidate tumor suppressor and other target genes by 1,25(OH)2D3 in colon cancer cells". |
reviewed | p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities. |
| More detail of all 2 literatures about RHOA | |
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Pathways and Diseases |
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Pathway | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway;PANTHER;P00027 |
Pathway | Signaling by GPCR;Reactome;REACT:14797 |
Pathway | S1P3 pathway;PID Curated;200035 |
Pathway | Bacterial invasion of epithelial cells;KEGG PATHWAY;hsa05100 |
Pathway | N-cadherin signaling events;PID Curated;200180 |
Pathway | Regulation of RhoA activity;PID Curated;200050 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | Sema4D mediated inhibition of cell attachment and migration;PID Reactome;500073 |
Pathway | EPHA2 forward signaling;PID Curated;200185 |
Pathway | Lissencephaly gene (LIS1) in neuronal migration and development;PID Curated;200114 |
Pathway | E-cadherin signaling in the nascent adherens junction;PID Curated;200105 |
Pathway | EPHA forward signaling;PID Curated;200121 |
Pathway | Paxillin-independent events mediated by a4b1 and a4b7;PID Curated;200178 |
Pathway | Signaling events mediated by PTP1B;PID Curated;200033 |
Pathway | S1P4 pathway;PID Curated;200043 |
Pathway | Pancreatic secretion;KEGG PATHWAY;hsa04972 |
Pathway | ccr3 signaling in eosinophils;PID BioCarta;100215 |
Pathway | TGF-beta signaling pathway;KEGG PATHWAY;hsa04350 |
Pathway | role of egf receptor transactivation by gpcrs in cardiac hypertrophy;PID BioCarta;100221 |
Pathway | Syndecan-2-mediated signaling events;PID Curated;200164 |
Pathway | Syndecan-4-mediated signaling events;PID Curated;200115 |
Pathway | p75(NTR)-mediated signaling;PID Curated;200103 |
Pathway | Signaling events mediated by PRL;PID Curated;200006 |
Pathway | rho-selective guanine exchange factor akap13 mediates stress fiber formation;PID BioCarta;100248 |
Pathway | IL2-mediated signaling events;PID Curated;200082 |
Pathway | Colorectal cancer;KEGG PATHWAY;hsa05210 |
Pathway | Adherens junction;KEGG PATHWAY;hsa04520 |
Pathway | G beta:gamma signalling through PI3Kgamma;PID Reactome;500439 |
Pathway | ucalpain and friends in cell spread;PID BioCarta;100008 |
Pathway | Thromboxane A2 receptor signaling;PID Curated;200069 |
Pathway | Noncanonical Wnt signaling pathway;PID Curated;200016 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | amb2 Integrin signaling;PID Curated;200108 |
Pathway | influence of ras and rho proteins on g1 to s transition;PID BioCarta;100054 |
Pathway | role of pi3k subunit p85 in regulation of actin organization and cell migration;PID BioCarta;100211 |
Pathway | Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722 |
Pathway | d4gdi signaling pathway;PID BioCarta;100191 |
Pathway | thrombin signaling and protease-activated receptors;PID BioCarta;100082 |
Pathway | Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810 |
Pathway | RhoA signaling pathway;PID Curated;200007 |
Pathway | PI3K/AKT signalling;PID Reactome;500639 |
Pathway | E-cadherin signaling in keratinocytes;PID Curated;200125 |
Pathway | trefoil factors initiate mucosal healing;PID BioCarta;100018 |
Pathway | Class I PI3K signaling events;PID Curated;200098 |
Pathway | S1P1 pathway;PID Curated;200071 |
Pathway | T cell receptor signaling pathway;KEGG PATHWAY;hsa04660 |
Pathway | TGF-beta receptor signaling;PID Curated;200195 |
Pathway | Axon guidance;KEGG PATHWAY;hsa04360 |
Pathway | Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | Pathogenic Escherichia coli infection;KEGG PATHWAY;hsa05130 |
Pathway | S1P2 pathway;PID Curated;200181 |
Pathway | Endogenous TLR signaling;PID Curated;200177 |
Pathway | Integrin signalling pathway;PANTHER;P00034 |
Pathway | ras signaling pathway;PID BioCarta;100047 |
Pathway | Ras Pathway;PANTHER;P04393 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | role of mal in rho-mediated activation of srf;PID BioCarta;100114 |
Pathway | erk and pi-3 kinase are necessary for collagen binding in corneal epithelia;PID BioCarta;100184 |
Pathway | Aurora B signaling;PID Curated;200010 |
Pathway | Axonal growth stimulation;PID Reactome;500618 |
Pathway | Vascular smooth muscle contraction;KEGG PATHWAY;hsa04270 |
Pathway | Endocytosis;KEGG PATHWAY;hsa04144 |
Pathway | Signaling events regulated by Ret tyrosine kinase;PID Curated;200058 |
Pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met);PID Curated;200032 |
Pathway | LPA receptor mediated events;PID Curated;200011 |
Pathway | Wnt signaling pathway;KEGG PATHWAY;hsa04310 |
Pathway | protein kinase a at the centrosome;PID BioCarta;100246 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | Signaling by Rho GTPases;Reactome;REACT:11044 |
Pathway | rho cell motility signaling pathway;PID BioCarta;100041 |
Pathway | Leukocyte transendothelial migration;KEGG PATHWAY;hsa04670 |
Pathway | Signaling events mediated by focal adhesion kinase;PID Curated;200192 |
Pathway | PLK1 signaling events;PID Curated;200087 |
Pathway | Arf6 downstream pathway;PID Curated;200079 |
Pathway | Signaling events mediated by VEGFR1 and VEGFR2;PID Curated;200161 |
Pathway | S1P5 pathway;PID Curated;200063 |
Pathway | Axon guidance mediated by semaphorins;PANTHER;P00007 |
Pathway | Plasma membrane estrogen receptor signaling;PID Curated;200029 |
Pathway | mTOR signaling pathway;PID Curated;200080 |
Pathway | Axonal growth inhibition (RHOA activation);PID Reactome;500619 |
Pathway | Integrins in angiogenesis;PID Curated;200109 |
Pathway | integrin signaling pathway;PID BioCarta;100123 |
Pathway | Chemokine signaling pathway;KEGG PATHWAY;hsa04062 |
Pathway | Tight junction;KEGG PATHWAY;hsa04530 |
Pathway | Stabilization and expansion of the E-cadherin adherens junction;PID Curated;200155 |
Pathway | Netrin-mediated signaling;PID Curated;200074 |
Disease | Hamman-Rich syndrome;FunDO |
Disease | IGA glomerulonephritis;FunDO |
Disease | Rheumatoid arthritis;FunDO |
Disease | Cancer;FunDO |
Disease | Labor, Premature;FunDO |
Disease | Vaccinia;FunDO |
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External Links |
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Links to Entrez Gene | 387 |
Links to all GeneRIF Items | 387 |
Links to iHOP | 387 |
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Sequence Information |
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Nucleotide Sequence |
>387 : length: 582 atggctgccatccggaagaaactggtgattgttggtgatggagcctgtggaaagacatgc ttgctcatagtcttcagcaaggaccagttcccagaggtgtatgtgcccacagtgtttgag aactatgtggcagatatcgaggtggatggaaagcaggtagagttggctttgtgggacaca gctgggcaggaagattatgatcgcctgaggcccctctcctacccagataccgatgttata ctgatgtgtttttccatcgacagccctgatagtttagaaaacatcccagaaaagtggacc ccagaagtcaagcatttctgtcccaacgtgcccatcatcctggttgggaataagaaggat cttcggaatgatgagcacacaaggcgggagctagccaagatgaagcaggagccggtgaaa cctgaagaaggcagagatatggcaaacaggattggcgcttttgggtacatggagtgttca gcaaagaccaaagatggagtgagagaggtttttgaaatggctacgagagctgctctgcaa gctagacgtgggaagaaaaaatctgggtgccttgtcttgtga |
Protein Sequence |
>387 : length: 193 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDT AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD LRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQ ARRGKKKSGCLVL |