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| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 4221 |
Name | MEN1 |
Synonym | MEAI|MENIN|SCG2;multiple endocrine neoplasia I;MEN1;multiple endocrine neoplasia I |
Definition | endocrine adenomatosis, multiple|menin |
Position | 11q13 |
Gene Type | protein-coding |
Source | Count: 3; Pubmed_search,TAG,Generif |
Literature support | Count: 31 PubMed records as below. |
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Evidence Status |
Description |
reviewed | Somatic mutations of the MEN1 tumor suppressor gene detected in sporadic angiofibromas. |
reviewed | tumor suppressor menin represses paired box gene 2 expression via Wilms tumor suppressor protein-polycomb group complex. |
reviewed | the menin tumor suppressor protein undergoes DNA damage induced phosphorylation and participates in the DNA damage transcriptional response. |
reviewed | The tumor suppressor protein menin inhibits AKT activation by regulating its cellular localization. |
reviewed | Concomitant deletions of tumor suppressor genes MEN1 and AIP are essential for the pathogenesis of the brown fat tumor hibernoma. |
reviewed | The multiple endocrine neoplasia type 1 (MEN1) tumor suppressor regulates peroxisome proliferator-activated receptor gamma-dependent adipocyte differentiation. |
reviewed | Decreased expression and promoter methylation of the menin tumor suppressor in pancreatic ductal adenocarcinoma. |
reviewed | Phosphorylation of the menin tumor suppressor protein on serine 543 and serine 583. |
reviewed | analysis of menin's role as a tumor suppressor and binding sites of Rbbp5 and MLL1. |
reviewed | The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes. |
| More detail of all 31 literatures about MEN1 | |
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External Links |
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Links to Entrez Gene | 4221 |
Links to all GeneRIF Items | 4221 |
Links to iHOP | 4221 |
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Sequence Information |
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Nucleotide Sequence |
>4221 : length: 1848 atggggctgaaggccgcccagaagacgctgttcccgctgcgctccatcgacgacgtggtg cgcctgtttgctgccgagctgggccgagaggagccggacctggtgctcctttccttggtg ctgggcttcgtggagcattttctggctgtcaaccgcgtcatccctaccaacgttcccgag ctcaccttccagcccagccccgcccccgacccgcctggcggcctcacctactttcccgtg gccgacctgtctatcatcgccgccctctatgcccgcttcaccgcccagatccgaggcgcc gtcgacctgtccctctatcctcgagaagggggtgtctccagccgtgagctggtgaagaag gtctccgatgtcatatggaacagcctcagccgctcctacttcaaggatcgggcccacatc cagtccctcttcagcttcatcacaggttggagcccagtaggcaccaaattggacagctcc ggtgtggcctttgctgtggttggggcctgccaggccctgggtctccgggatgtccacctc gccctgtctgaggatcatgcctgggtagtgtttgggcccaatggggagcagacagctgag gtcacctggcacggcaagggcaacgaggaccgcaggggccagacagtcaatgccggtgtg gctgagcggagctggctgtacctgaaaggatcatacatgcgctgtgaccgcaagatggag gtggcgttcatggtgtgtgccatcaacccttccattgacctgcacaccgactcgctggag cttctgcagctgcagcagaagctgctctggctgctctatgacctgggacatctggaaagg taccccatggccttagggaacctggcagatctagaggagctggagcccacccctggccgg ccagacccactcaccctctaccacaagggcattgcctcagccaagacctactatcgggat gaacacatctacccctacatgtacctggctggctaccactgtcgcaaccgcaatgtgcgg gaagccctgcaggcctgggcggacacggccactgtcatccaggactacaactactgccgg gaagacgaggagatctacaaggagttctttgaagtagccaatgatgtcatccccaacctg ctgaaggaggcagccagcttgctggaggcgggcgaggagcggccgggggagcaaagccag ggcacccagagccaaggttccgccctccaggaccctgagtgcttcgcccacctgctgcga ttctacgacggcatctgcaaatgggaggagggcagtcccacgcctgtgctgcacgtgggc tgggccacctttcttgtgcagtccctaggccgttttgagggacaggtgcggcagaaggtg cgcatagtgagccgagaggccgaggcggccgaggccgaggagccgtggggcgaggaagcc cgggaaggccggcggcggggcccacggcgggagtccaagccagaggagcccccgccgccc aagaagccagcactggacaagggcctgggcaccggccagggtgcagtgtcaggacccccc cggaagcctcctgggactgtcgctggcacagcccgaggccctgaaggtggcagcacggct caggtgccagcacccgcagcatcaccaccgccggagggtccagtgctcactttccagagt gagaagatgaagggcatgaaggagctgctggtggccaccaagatcaactcgagcgccatc aagctgcaactcacggcacagtcgcaagtgcagatgaagaagcagaaagtgtccacccct agtgactacactctgtctttcctcaagcggcagcgcaaaggcctctga |
Protein Sequence |
>4221 : length: 615 MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPE LTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKK VSDVIWNSLSRSYFKDRAHIQSLFSFITGWSPVGTKLDSSGVAFAVVGACQALGLRDVHL ALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKME VAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGR PDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCR EDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLR FYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEA REGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTA QVPAPAASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTP SDYTLSFLKRQRKGL |