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| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 4221 |
Name | MEN1 |
Synonymous | MEAI|MENIN|SCG2;multiple endocrine neoplasia I;MEN1;multiple endocrine neoplasia I |
Definition | endocrine adenomatosis, multiple|menin |
Position | 11q13 |
Gene Type | protein-coding |
Gene Mutation: | Substitution Insertion & Deletion Other Mutation |
Substitution | | Top | |
|
Mutation (Type; AA; Chr) |
Site |
Histology |
|---|---|---|
Substitution - coding silent; c.1779C>A; |
y; breast | carcinoma |
Substitution - coding silent; c.909C>T; 11:64331062-64331062 |
central_nervous_system; brain | glioblastoma_multiforme; astrocytoma_Grade_IV; glioma |
Indel | | Top | |
|
Mutation (Type; AA; Chr) |
Site |
Histology |
|---|---|---|
Deletion - Frameshift; c.248_272del25; 11:64333886-64333910 |
NS | gastrinoma; carcinoid-endocrine_tumour |
Deletion - Frameshift; c.1159delG; 11:64329709-64329709 |
pancreas | gastrinoma; carcinoid-endocrine_tumour |
Deletion - Frameshift; c.1116delC; 11:64329752-64329752 |
lung | small_cell_carcinoma; carcinoma |
Deletion - Frameshift; c.1318_1319delCT; 11:64329113-64329114 |
thymus | ACTH; carcinoid-endocrine_tumour |
Deletion - Frameshift; c.671_675delAAGGA; 11:64331708-64331712 |
parathyroid | adenoma-hyperplasia_NS |
Deletion - Frameshift; c.258_261delCGCC; 11:64333897-64333900 |
parathyroid | adenoma |
Deletion - Frameshift; c.207_207delC; 11:64333951-64333951 |
parathyroid | adenoma |
Deletion - Frameshift; c.203_203delC; 11:64333955-64333955 |
n; pancreas | carcinoid-endocrine_tumour |
Deletion - Frameshift; c.561_561delG; 11:64332032-64332032 |
n; pancreas | carcinoid-endocrine_tumour |
Deletion - Frameshift; c.800_822del23; 11:64331229-64331251 |
n; pancreas | carcinoid-endocrine_tumour |
Deletion - Frameshift; c.960_960delC; 11:64330369-64330369 |
n; pancreas | carcinoid-endocrine_tumour |
Deletion - Frameshift; c.673delG; 11:64331710-64331710 |
gastrointestinal_tract_(site_i | gastrinoma; carcinoid-endocrine_tumour |
Deletion - Frameshift; c.292delC; 11:64333866-64333866 |
parathyroid | adenoma |
Deletion - Frameshift; c.372_393del22; 11:64333765-64333786 |
parathyroid | adenoma |
Deletion - Frameshift; c.620delG; 11:64331973-64331973 |
small_intestine; duodenum | gastrinoma; carcinoid-endocrine_tumour |
Deletion - Frameshift; c.1361_1362delAG; 11:64328853-64328854 |
parathyroid | hyperplasia |
Deletion - Frameshift; c.151delA; 11:64334007-64334007 |
parathyroid | adenoma |
Deletion - Frameshift; c.268delT; 11:64333890-64333890 |
pituitary | PRL; adenoma |
Deletion - Frameshift; c.163_173del11; 11:64333985-64333995 |
parathyroid | adenoma |
Deletion - In frame; c.398_430del33; 11:64333728-64333760 |
parathyroid | adenoma |
Deletion - Frameshift; c.652_653delCG; 11:64331940-64331941 |
n; pancreas | carcinoid-endocrine_tumour |
Deletion - Frameshift; c.159_165delCATCCCT; 11:64333993-64333999 |
n; pancreas | carcinoid-endocrine_tumour |
Deletion - Frameshift; c.249_252delGTCT; 11:64333906-64333909 |
y; pancreas | islet_cell; carcinoid-endocrine_tumour |
Deletion - Frameshift; c.402delC; 11:64333756-64333756 |
gastrointestinal_tract_(site_i | gastrinoma; carcinoid-endocrine_tumour |
Deletion - Frameshift; c.620delG; 11:64331973-64331973 |
small_intestine; duodenum | gastrinoma; carcinoid-endocrine_tumour |
Deletion - Frameshift; c.1360delA; 11:64328855-64328855 |
parathyroid | adenoma |
Deletion - Frameshift; c.37_97del61; 11:64334061-64334121 |
pancreas | gastrinoma; carcinoid-endocrine_tumour |
Deletion - Frameshift; c.212_218delCGCCTGG; 11:64333940-64333946 |
pancreas | carcinoid-endocrine_tumour |
Deletion - Frameshift; c.1033delG; 11:64330296-64330296 |
pancreas | gastrinoma; carcinoid-endocrine_tumour |
Deletion - Frameshift; c.249_252delGTCT; 11:64333906-64333909 |
n; pancreas | carcinoid-endocrine_tumour |
Deletion - Frameshift; c.373_374delAT; 11:64333784-64333785 |
NS | gastrinoma; carcinoid-endocrine_tumour |
Deletion - In frame; c.398_430del33; 11:64333728-64333760 |
parathyroid | adenoma-hyperplasia_NS |
Deletion - Frameshift; c.247_250delCTGT; 11:64333908-64333911 |
stomach | carcinoid-endocrine_tumour |
Deletion - In frame; c.660_668del9; 11:64331715-64331723 |
pancreas | gastrinoma; carcinoid-endocrine_tumour |
Deletion - Frameshift; c.242delC; 11:64333916-64333916 |
parathyroid | adenoma-hyperplasia_NS |
Deletion - Frameshift; c.794delG; 11:64331257-64331257 |
gastrointestinal_tract_(site_i | carcinoid-endocrine_tumour |
Deletion - In frame; c.354_356delGAA; 11:64333802-64333804 |
gastrointestinal_tract_(site_i | carcinoid-endocrine_tumour |
Deletion - Frameshift; c.39delG; 11:64334119-64334119 |
parathyroid | adenoma |
Deletion - Frameshift; c.237_237delC; 11:64333921-64333921 |
pituitary | GH-PRL; adenoma |
Deletion - Frameshift; c.50_53delACGA; 11:64334105-64334108 |
y; pancreas | islet_cell; carcinoid-endocrine_tumour |
Deletion - Frameshift; c.620delG; 11:64331973-64331973 |
gastrointestinal_tract_(site_i | gastrinoma; carcinoid-endocrine_tumour |
Deletion - In frame; c.1623_1652del30; 11:64328563-64328592 |
gastrointestinal_tract_(site_i | gastrinoma; carcinoid-endocrine_tumour |
Deletion - Frameshift; c.437delT; 11:64333721-64333721 |
parathyroid | adenoma |
Deletion - Frameshift; c.199_202delCCCG; 11:64333956-64333959 |
parathyroid | adenoma |
Deletion - Frameshift; c.24_36del13; 11:64334122-64334134 |
lung | atypical; carcinoid-endocrine_tumour |
Deletion - Frameshift; c.373_374delAT; 11:64333784-64333785 |
pancreas | gastrinoma; carcinoid-endocrine_tumour |
Deletion - Frameshift; c.1102_1108delGCCAATG; 11:64329760-64329766 |
NS | gastrinoma; carcinoid-endocrine_tumour |
Deletion - Frameshift; c.210_225del16; 11:64333933-64333948 |
pancreas | gastrinoma; carcinoid-endocrine_tumour |
Deletion - Frameshift; c.412delG; 11:64333746-64333746 |
pancreas | vipoma; carcinoid-endocrine_tumour |
Deletion - Frameshift; c.194_219del26; 11:64333939-64333964 |
parathyroid | adenoma |
Deletion - Frameshift; c.?_?delTGTC; |
soft_tissue; fat | lipoma |
Deletion - Frameshift; c.1033delG; 11:64330296-64330296 |
gastrointestinal_tract_(site_i | gastrinoma; carcinoid-endocrine_tumour |
Deletion - Frameshift; c.1702_1706delACCAA; 11:64328509-64328513 |
parathyroid | adenoma |
Deletion - Frameshift; c.168_171delCAAC; 11:64333987-64333990 |
parathyroid | carcinoma |
Deletion - Frameshift; c.282_282delC; 11:64333876-64333876 |
n; pancreas | carcinoid-endocrine_tumour |
Deletion - Frameshift; c.1038_1038delT; 11:64330291-64330291 |
n; pancreas | carcinoid-endocrine_tumour |
Deletion - In frame; c.794_802del9; 11:64331249-64331257 |
parathyroid | adenoma |
Deletion - Frameshift; c.373_374delAT; 11:64333784-64333785 |
NS | gastrinoma; carcinoid-endocrine_tumour |
Deletion - Frameshift; c.291_292delCC; 11:64333866-64333867 |
parathyroid | adenoma |
Deletion - In frame; c.1240_1275del36; 11:64329157-64329192 |
parathyroid | hyperplasia |
Deletion - Frameshift; c.221delG; 11:64333937-64333937 |
parathyroid | hyperplasia |
Deletion - Frameshift; c.802_803delTA; 11:64331248-64331249 |
parathyroid | adenoma |
Deletion - Frameshift; c.1313_1331del19; 11:64329101-64329119 |
parathyroid | adenoma |
Deletion - Frameshift; c.1033delG; 11:64330296-64330296 |
small_intestine; duodenum | gastrinoma; carcinoid-endocrine_tumour |
Deletion - In frame; c.1716_1721delGAGCGC; 11:64328494-64328499 |
parathyroid | adenoma |
Deletion - Frameshift; c.377_377delG; 11:64333781-64333781 |
n; pancreas | carcinoid-endocrine_tumour |
Deletion - Frameshift; c.419delT; 11:64333739-64333739 |
gastrointestinal_tract_(site_i | gastrinoma; carcinoid-endocrine_tumour |
Deletion - In frame; c.83_118del36; 11:64334040-64334075 |
parathyroid | adenoma |
Deletion - Frameshift; c.1102_1108delGCCAATG; 11:64329760-64329766 |
small_intestine; duodenum | gastrinoma; carcinoid-endocrine_tumour |
Deletion - In frame; c.440_442delTCA; 11:64333716-64333718 |
pancreas | gastrinoma; carcinoid-endocrine_tumour |
Deletion - Frameshift; c.248_251delTGTC; 11:64333907-64333910 |
pancreas | gastrinoma; carcinoid-endocrine_tumour |
Deletion - Frameshift; c.342delC; 11:64333816-64333816 |
parathyroid | adenoma-hyperplasia_NS |
Deletion - Frameshift; c.1034delC; 11:64330295-64330295 |
parathyroid | adenoma-hyperplasia_NS |
Deletion - Frameshift; c.405delG; 11:64333753-64333753 |
parathyroid | adenoma |
Deletion - Frameshift; c.44_59del16; 11:64334099-64334114 |
parathyroid | adenoma |
Deletion - Frameshift; c.330_346del17; 11:64333812-64333828 |
n; pancreas | carcinoid-endocrine_tumour |
Deletion - Frameshift; c.156_156delC; 11:64334002-64334002 |
n; pancreas | carcinoid-endocrine_tumour |
Deletion - Frameshift; c.1_109del109; 11:64334049-64334157 |
n; pancreas | carcinoid-endocrine_tumour |
Deletion - Frameshift; c.620delG; 11:64331973-64331973 |
small_intestine; duodenum | gastrinoma; carcinoid-endocrine_tumour |
Deletion - Frameshift; c.1102_1108delGCCAATG; 11:64329760-64329766 |
small_intestine; duodenum | gastrinoma; carcinoid-endocrine_tumour |
Deletion - Frameshift; c.754_761delGACTCGCT; 11:64331622-64331629 |
parathyroid | adenoma |
Deletion - In frame; c.354_356delGAA; 11:64333802-64333804 |
parathyroid | adenoma |
Deletion - Frameshift; c.1657delT; 11:64328558-64328558 |
parathyroid | adenoma-hyperplasia_NS |
Deletion - Frameshift; c.1657delT; 11:64328558-64328558 |
parathyroid | hyperplasia |
Deletion - Frameshift; c.1351delG; 11:64328864-64328864 |
lung | atypical; carcinoid-endocrine_tumour |
Deletion - Frameshift; c.247_250delCTGT; 11:64333908-64333911 |
small_intestine; duodenum | gastrinoma; carcinoid-endocrine_tumour |
Deletion - Frameshift; c.1704delC; 11:64328511-64328511 |
parathyroid | adenoma-hyperplasia_NS |
Deletion - In frame; c.725_742del18; 11:64331641-64331658 |
parathyroid | adenoma |
Deletion - In frame; c.?; |
parathyroid | adenoma-hyperplasia_NS |
Deletion - Frameshift; c.?_?del?; |
pancreas | insulinoma; carcinoid-endocrine_tumour |
Deletion - Frameshift; c.249_252delGTCT; 11:64333906-64333909 |
pancreas | vipoma; carcinoid-endocrine_tumour |
Deletion - Frameshift; c.51delC; 11:64334107-64334107 |
soft_tissue; fat | lipoma |
Deletion - Frameshift; c.1256delG; 11:64329176-64329176 |
parathyroid | carcinoma |
Deletion - Frameshift; c.1217delA; 11:64329215-64329215 |
retroperitoneum | carcinoid-endocrine_tumour |
Deletion - Frameshift; c.734delC; 11:64331649-64331649 |
pancreas | glucagonoma; carcinoid-endocrine_tumour |
Deletion - Frameshift; c.79_95del17; 11:64334063-64334079 |
n; pancreas | carcinoid-endocrine_tumour |
Deletion - Frameshift; c.817_818delCT; 11:64331233-64331234 |
y; pancreas | islet_cell; carcinoid-endocrine_tumour |
Other Mutation | | Top | |
|
Mutation (Type; AA; Chr) |
Site |
Histology |
|---|---|---|
Complex - frameshift; c.341_376>TC; 11:64333782-64333817 |
parathyroid | hyperplasia |
Complex - frameshift; c.196_201AGCCCC>T; 11:64333957-64333962 |
gastrointestinal_tract_(site_i | gastrinoma; carcinoid-endocrine_tumour |
Complex - deletion inframe; c.8_42>GGCCT; 11:64334116-64334150 |
parathyroid | hyperplasia |
Complex - frameshift; c.218_228>CCT; 11:64333930-64333940 |
pancreas | gastrinoma; carcinoid-endocrine_tumour |
Complex - frameshift; c.597_597C>GG; 11:64331996-64331996 |
parathyroid | adenoma-hyperplasia_NS |