|
|
||
|
|
||
| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 54790 |
Name | TET2 |
Synonym | KIAA1546|MDS;tet methylcytosine dioxygenase 2;TET2;tet methylcytosine dioxygenase 2 |
Definition | methylcytosine dioxygenase TET2|probable methylcytosine dioxygenase TET2|tet oncogene family member 2 |
Position | 4q24 |
Gene Type | protein-coding |
Source | Count: 2; Generif,UniProt |
Literature support | Count: 4 PubMed records as below. |
|
Evidence Status |
Description |
reviewed | "TET2, a tumor suppressor in hematological disorders." |
potential | "With diverse genetic methods, TET2 on chromosome 4q24 was identified as candidate tumor suppressor gene." |
reviewed | It has been suggested that TET2 is a tumor suppressor gene and mutations in TET2 precede the acquisition of JAK2-V617F. |
potential | "TET2 (TET oncogene family member 2) is a candidate tumor suppressor gene located at chromosome 4q24, and was recently reported to be mutated in approximately 14% of patients with JAK2V617F-positive myeloproliferative neoplasms. ". |
| More detail of all 4 literatures about TET2 | |
|
External Links |
|
Links to Entrez Gene | 54790 |
Links to all GeneRIF Items | 54790 |
Links to iHOP | 54790 |
|
Sequence Information |
|
Nucleotide Sequence |
>54790 : length: 6009 atggaacaggatagaaccaaccatgttgagggcaacagactaagtccattcctgatacca tcacctcccatttgccagacagaacctctggctacaaagctccagaatggaagcccactg cctgagagagctcatccagaagtaaatggagacaccaagtggcactctttcaaaagttat tatggaataccctgtatgaagggaagccagaatagtcgtgtgagtcctgactttacacaa gaaagtagagggtattccaagtgtttgcaaaatggaggaataaaacgcacagttagtgaa ccttctctctctgggctccttcagatcaagaaattgaaacaagaccaaaaggctaatgga gaaagacgtaacttcggggtaagccaagaaagaaatccaggtgaaagcagtcaaccaaat gtctccgatttgagtgataagaaagaatctgtgagttctgtagcccaagaaaatgcagtt aaagatttcaccagtttttcaacacataactgcagtgggcctgaaaatccagagcttcag attctgaatgagcaggaggggaaaagtgctaattaccatgacaagaacattgtattactt aaaaacaaggcagtgctaatgcctaatggtgctacagtttctgcctcttccgtggaacac acacatggtgaactcctggaaaaaacactgtctcaatattatccagattgtgtttccatt gcggtgcagaaaaccacatctcacataaatgccattaacagtcaggctactaatgagttg tcctgtgagatcactcacccatcgcatacctcagggcagatcaattccgcacagacctct aactctgagctgcctccaaagccagctgcagtggtgagtgaggcctgtgatgctgatgat gctgataatgccagtaaactagctgcaatgctaaatacctgttcctttcagaaaccagaa caactacaacaacaaaaatcagtttttgagatatgcccatctcctgcagaaaataacatc cagggaaccacaaagctagcgtctggtgaagaattctgttcaggttccagcagcaatttg caagctcctggtggcagctctgaacggtatttaaaacaaaatgaaatgaatggtgcttac ttcaagcaaagctcagtgttcactaaggattccttttctgccactaccacaccaccacca ccatcacaattgcttctttctccccctcctcctcttccacaggttcctcagcttccttca gaaggaaaaagcactctgaatggtggagttttagaagaacaccaccactaccccaaccaa agtaacacaacacttttaagggaagtgaaaatagagggtaaacctgaggcaccaccttcc cagagtcctaatccatctacacatgtatgcagcccttctccgatgctttctgaaaggcct cagaataattgtgtgaacaggaatgacatacagactgcagggacaatgactgttccattg tgttctgagaaaacaagaccaatgtcagaacacctcaagcataacccaccaatttttggt agcagtggagagctacaggacaactgccagcagttgatgagaaacaaagagcaagagatt ctgaagggtcgagacaaggagcaaacacgagatcttgtgcccccaacacagcactatctg aaaccaggatggattgaattgaaggcccctcgttttcaccaagcggaatcccatctaaaa cgtaatgaggcatcactgccatcaattcttcagtatcaacccaatctctccaatcaaatg acctccaaacaatacactggaaattccaacatgcctggggggctcccaaggcaagcttac acccagaaaacaacacagctggagcacaagtcacaaatgtaccaagttgaaatgaatcaa gggcagtcccaaggtacagtggaccaacatctccagttccaaaaaccctcacaccaggtg cacttctccaaaacagaccatttaccaaaagctcatgtgcagtcactgtgtggcactaga tttcattttcaacaaagagcagattcccaaactgaaaaacttatgtccccagtgttgaaa cagcacttgaatcaacaggcttcagagactgagccattttcaaactcacaccttttgcaa cataagcctcataaacaggcagcacaaacacaaccatcccagagttcacatctccctcaa aaccagcaacagcagcaaaaattacaaataaagaataaagaggaaatactccagactttt cctcacccccaaagcaacaatgatcagcaaagagaaggatcattctttggccagactaaa gtggaagaatgttttcatggtgaaaatcagtattcaaaatcaagcgagttcgagactcat aatgtccaaatgggactggaggaagtacagaatataaatcgtagaaattccccttatagt cagaccatgaaatcaagtgcatgcaaaatacaggtttcttgttcaaacaatacacaccta gtttcagagaataaagaacagactacacatcctgaactttttgcaggaaacaagacccaa aacttgcatcacatgcaatattttccaaataatgtgatcccaaagcaagatcttcttcac aggtgctttcaagaacaggagcagaagtcacaacaagcttcagttctacagggatataaa aatagaaaccaagatatgtctggtcaacaagctgcgcaacttgctcagcaaaggtacttg atacataaccatgcaaatgtttttcctgtgcctgaccagggaggaagtcacactcagacc cctccccagaaggacactcaaaagcatgctgctctaaggtggcatctcttacagaagcaa gaacagcagcaaacacagcaaccccaaactgagtcttgccatagtcagatgcacaggcca attaaggtggaacctggatgcaagccacatgcctgtatgcacacagcaccaccagaaaac aaaacatggaaaaaggtaactaagcaagagaatccacctgcaagctgtgataatgtgcag caaaagagcatcattgagaccatggagcagcatctgaagcagtttcacgccaagtcgtta tttgaccataaggctcttactctcaaatcacagaagcaagtaaaagttgaaatgtcaggg ccagtcacagttttgactagacaaaccactgctgcagaacttgatagccacaccccagct ttagagcagcaaacaacttcttcagaaaagacaccaaccaaaagaacagctgcttctgtt ctcaataattttatagagtcaccttccaaattactagatactcctataaaaaatttattg gatacacctgtcaagactcaatatgatttcccatcttgcagatgtgtagagcaaattatt gaaaaagatgaaggtcctttttatacccatctaggagcaggtcctaatgtggcagctatt agagaaatcatggaagaaaggtttggacagaagggtaaagctattaggattgaaagagtc atctatactggtaaagaaggcaaaagttctcagggatgtcctattgctaagtgggtggtt cgcagaagcagcagtgaagagaagctactgtgtttggtgcgggagcgagctggccacacc tgtgaggctgcagtgattgtgattctcatcctggtgtgggaaggaatcccgctgtctctg gctgacaaactctactcggagcttaccgagacgctgaggaaatacggcacgctcaccaat cgccggtgtgccttgaatgaagagagaacttgcgcctgtcaggggctggatccagaaacc tgtggtgcctccttctcttttggttgttcatggagcatgtactacaatggatgtaagttt gccagaagcaagatcccaaggaagtttaagctgcttggggatgacccaaaagaggaagag aaactggagtctcatttgcaaaacctgtccactcttatggcaccaacatataagaaactt gcacctgatgcatataataatcagattgaatatgaacacagagcaccagagtgccgtctg ggtctgaaggaaggccgtccattctcaggggtcactgcatgtttggacttctgtgctcat gcccacagagacttgcacaacatgcagaatggcagcacattggtatgcactctcactaga gaagacaatcgagaatttggaggaaaacctgaggatgagcagcttcacgttctgccttta tacaaagtctctgacgtggatgagtttgggagtgtggaagctcaggaggagaaaaaacgg agtggtgccattcaggtactgagttcttttcggcgaaaagtcaggatgttagcagagcca gtcaagacttgccgacaaaggaaactagaagccaagaaagctgcagctgaaaagctttcc tccctggagaacagctcaaataaaaatgaaaaggaaaagtcagccccatcacgtacaaaa caaactgaaaacgcaagccaggctaaacagttggcagaacttttgcgactttcaggacca gtcatgcagcagtcccagcagccccagcctctacagaagcagccaccacagccccagcag cagcagagaccccagcagcagcagccacatcaccctcagacagagtctgtcaactcttat tctgcttctggatccaccaatccatacatgagacggcccaatccagttagtccttatcca aactcttcacacacttcagatatctatggaagcaccagccctatgaacttctattccacc tcatctcaagctgcaggttcatatttgaattcttctaatcccatgaacccttaccctggg cttttgaatcagaatacccaatatccatcatatcaatgcaatggaaacctatcagtggac aactgctccccatatctgggttcctattctccccagtctcagccgatggatctgtatagg tatccaagccaagaccctctgtctaagctcagtctaccacccatccatacactttaccag ccaaggtttggaaatagccagagttttacatctaaatacttaggttatggaaaccaaaat atgcagggagatggtttcagcagttgtaccattagaccaaatgtacatcatgtagggaaa ttgcctccttatcccactcatgagatggatggccacttcatgggagccacctctagatta ccacccaatctgagcaatccaaacatggactataaaaatggtgaacatcattcaccttct cacataatccataactacagtgcagctccgggcatgttcaacagctctcttcatgccctg catctccaaaacaaggagaatgacatgctttcccacacagctaatgggttatcaaagatg cttccagctcttaaccatgatagaactgcttgtgtccaaggaggcttacacaaattaagt gatgctaatggtcaggaaaagcagccattggcactagtccagggtgtggcttctggtgca gaggacaacgatgaggtctggtcagacagcgagcagagctttctggatcctgacattggg ggagtggccgtggctccaactcatgggtcaattctcattgagtgtgcaaagcgtgagctg catgccacaacccctttaaagaatcccaataggaatcaccccaccaggatctccctcgtc ttttaccagcataagagcatgaatgagccaaaacatggcttggctctttgggaagccaaa atggctgaaaaagcccgtgagaaagaggaagagtgtgaaaagtatggcccagactatgtg cctcagaaatcccatggcaaaaaagtgaaacgggagcctgctgagccacatgaaacttca gagcccacttacctgcgtttcatcaagtctcttgccgaaaggaccatgtccgtgaccaca gactccacagtaactacatctccatatgccttcactcgggtcacagggccttacaacaga tatatatga |
Protein Sequence |
>54790 : length: 2002 MEQDRTNHVEGNRLSPFLIPSPPICQTEPLATKLQNGSPLPERAHPEVNGDTKWHSFKSY YGIPCMKGSQNSRVSPDFTQESRGYSKCLQNGGIKRTVSEPSLSGLLQIKKLKQDQKANG ERRNFGVSQERNPGESSQPNVSDLSDKKESVSSVAQENAVKDFTSFSTHNCSGPENPELQ ILNEQEGKSANYHDKNIVLLKNKAVLMPNGATVSASSVEHTHGELLEKTLSQYYPDCVSI AVQKTTSHINAINSQATNELSCEITHPSHTSGQINSAQTSNSELPPKPAAVVSEACDADD ADNASKLAAMLNTCSFQKPEQLQQQKSVFEICPSPAENNIQGTTKLASGEEFCSGSSSNL QAPGGSSERYLKQNEMNGAYFKQSSVFTKDSFSATTTPPPPSQLLLSPPPPLPQVPQLPS EGKSTLNGGVLEEHHHYPNQSNTTLLREVKIEGKPEAPPSQSPNPSTHVCSPSPMLSERP QNNCVNRNDIQTAGTMTVPLCSEKTRPMSEHLKHNPPIFGSSGELQDNCQQLMRNKEQEI LKGRDKEQTRDLVPPTQHYLKPGWIELKAPRFHQAESHLKRNEASLPSILQYQPNLSNQM TSKQYTGNSNMPGGLPRQAYTQKTTQLEHKSQMYQVEMNQGQSQGTVDQHLQFQKPSHQV HFSKTDHLPKAHVQSLCGTRFHFQQRADSQTEKLMSPVLKQHLNQQASETEPFSNSHLLQ HKPHKQAAQTQPSQSSHLPQNQQQQQKLQIKNKEEILQTFPHPQSNNDQQREGSFFGQTK VEECFHGENQYSKSSEFETHNVQMGLEEVQNINRRNSPYSQTMKSSACKIQVSCSNNTHL VSENKEQTTHPELFAGNKTQNLHHMQYFPNNVIPKQDLLHRCFQEQEQKSQQASVLQGYK NRNQDMSGQQAAQLAQQRYLIHNHANVFPVPDQGGSHTQTPPQKDTQKHAALRWHLLQKQ EQQQTQQPQTESCHSQMHRPIKVEPGCKPHACMHTAPPENKTWKKVTKQENPPASCDNVQ QKSIIETMEQHLKQFHAKSLFDHKALTLKSQKQVKVEMSGPVTVLTRQTTAAELDSHTPA LEQQTTSSEKTPTKRTAASVLNNFIESPSKLLDTPIKNLLDTPVKTQYDFPSCRCVEQII EKDEGPFYTHLGAGPNVAAIREIMEERFGQKGKAIRIERVIYTGKEGKSSQGCPIAKWVV RRSSSEEKLLCLVRERAGHTCEAAVIVILILVWEGIPLSLADKLYSELTETLRKYGTLTN RRCALNEERTCACQGLDPETCGASFSFGCSWSMYYNGCKFARSKIPRKFKLLGDDPKEEE KLESHLQNLSTLMAPTYKKLAPDAYNNQIEYEHRAPECRLGLKEGRPFSGVTACLDFCAH AHRDLHNMQNGSTLVCTLTREDNREFGGKPEDEQLHVLPLYKVSDVDEFGSVEAQEEKKR SGAIQVLSSFRRKVRMLAEPVKTCRQRKLEAKKAAAEKLSSLENSSNKNEKEKSAPSRTK QTENASQAKQLAELLRLSGPVMQQSQQPQPLQKQPPQPQQQQRPQQQQPHHPQTESVNSY SASGSTNPYMRRPNPVSPYPNSSHTSDIYGSTSPMNFYSTSSQAAGSYLNSSNPMNPYPG LLNQNTQYPSYQCNGNLSVDNCSPYLGSYSPQSQPMDLYRYPSQDPLSKLSLPPIHTLYQ PRFGNSQSFTSKYLGYGNQNMQGDGFSSCTIRPNVHHVGKLPPYPTHEMDGHFMGATSRL PPNLSNPNMDYKNGEHHSPSHIIHNYSAAPGMFNSSLHALHLQNKENDMLSHTANGLSKM LPALNHDRTACVQGGLHKLSDANGQEKQPLALVQGVASGAEDNDEVWSDSEQSFLDPDIG GVAVAPTHGSILIECAKRELHATTPLKNPNRNHPTRISLVFYQHKSMNEPKHGLALWEAK MAEKAREKEEECEKYGPDYVPQKSHGKKVKREPAEPHETSEPTYLRFIKSLAERTMSVTT DSTVTTSPYAFTRVTGPYNRYI |