Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

5573

Name

PRKAR1A

Synonym

ADOHR|CAR|CNC|CNC1|PKR1|PPNAD1|PRKAR1|TSE1;protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1);PRKAR1A;protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)

Definition

cAMP-dependent protein kinase regulatory subunit RIalpha|cAMP-dependent protein kinase type I-alpha regulatory chain|cAMP-dependent protein kinase type I-alpha regulatory subunit|protein kinase A type 1a regulatory subunit|tissue-specific extinguisher 1

Position

17q23-q24

Gene Type

protein-coding

Source

Count: 2; Pubmed_search,Generif

Literature support

Count: 3 PubMed records as below.

Evidence Status

Description

reviewed

Reviews genetic aspects of hereditary GH-secreting tumors and data from animal models resulting from the inactivation of the PRKAR1A tumor suppressor gene.

reviewed

PRKAR1A might function as a tumor suppressor gene.

reviewed

Regulatory subunit type I-alpha of protein kinase A (PRKAR1A): a tumor-suppressor gene for sporadic thyroid cancer.
More detail of all 3 literatures about PRKAR1A

Pathways and Diseases

Pathway

transcription regulation by methyltransferase of carm1;PID BioCarta;100220

Pathway

Metabotropic glutamate receptor group III pathway;PANTHER;P00039

Pathway

Diabetes pathways;Reactome;REACT:15380

Pathway

Metabotropic glutamate receptor group I pathway;PANTHER;P00041

Pathway

phospholipase c-epsilon pathway;PID BioCarta;100070

Pathway

GABA-B receptor II signaling;PANTHER;P05731

Pathway

Muscarinic acetylcholine receptor 2 and 4 signaling pathway;PANTHER;P00043

Pathway

gata3 participate in activating the th2 cytokine genes expression;PID BioCarta;100157

Pathway

Transmembrane transport of small molecules;Reactome;REACT:15518

Pathway

Metabotropic glutamate receptor group II pathway;PANTHER;P00040

Pathway

attenuation of gpcr signaling;PID BioCarta;100253

Pathway

Opioid Signalling;Reactome;REACT:15295

Pathway

Apoptosis;KEGG PATHWAY;hsa04210

Pathway

Hedgehog signaling pathway;PANTHER;P00025

Pathway

Endothelin signaling pathway;PANTHER;P00019

Pathway

Signalling by NGF;Reactome;REACT:11061

Pathway

Insulin signaling pathway;KEGG PATHWAY;hsa04910

Pathway

signaling pathway from g-protein families;PID BioCarta;100153

Pathway

nitric oxide signaling pathway;PID BioCarta;100092

Pathway

activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor;PID BioCarta;100196

Pathway

how progesterone initiates the oocyte maturation;PID BioCarta;100104

Pathway

Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway;PANTHER;P00026

Pathway

transcription factor creb and its extracellular signals;PID BioCarta;100198

Pathway

actions of nitric oxide in the heart;PID BioCarta;100094

Pathway

stathmin and breast cancer resistance to antimicrotubule agents;PID BioCarta;100027

Pathway

Integration of energy metabolism;Reactome;REACT:1505

Pathway

Transcription regulation by bZIP transcription factor;PANTHER;P00055

Pathway

chrebp regulation by carbohydrates and camp;PID BioCarta;100203

Pathway

regulation of bad phosphorylation;PID BioCarta;100233

Pathway

activation of camp-dependent protein kinase pka;PID BioCarta;100151

Pathway

mcalpain and friends in cell motility;PID BioCarta;100111

Pathway

regulation of ck1/cdk5 by type 1 glutamate receptors;PID BioCarta;100201

Pathway

repression of pain sensation by the transcriptional regulator dream;PID BioCarta;100186

Pathway

cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway;PID BioCarta;100205

Disease

Adrenocortical tumor, somatic;OMIM

Disease

Carney complex, type 1;OMIM

Disease

Pigmented adrenocortical disease, primary, 1;OMIM

Disease

Thyroid carcinoma, papillary;OMIM

Disease

Myxoma, intracardiac;OMIM

External Links

Links to Entrez Gene

5573

Links to all GeneRIF Items

5573

Links to iHOP

5573

Sequence Information

Nucleotide Sequence

>5573 : length: 1146
atggagtctggcagtaccgccgccagtgaggaggcacgcagccttcgagaatgtgagctc
tacgtccagaagcataacattcaagcgctgctcaaagattctattgtgcagttgtgcact
gctcgacctgagagacccatggcattcctcagggaatactttgagaggttggagaaggag
gaggcaaaacagattcagaatctgcagaaagcaggcactcgtacagactcaagggaggat
gagatttctcctcctccacccaacccagtggttaaaggtaggaggcgacgaggtgctatc
agcgctgaggtctacacggaggaagatgcggcatcctatgttagaaaggttataccaaaa
gattacaagacaatggccgctttagccaaagccattgaaaagaatgtgctgttttcacat
cttgatgataatgagagaagtgatatttttgatgccatgttttcggtctcctttatcgca
ggagagactgtgattcagcaaggtgatgaaggggataacttctatgtgattgatcaagga
gagacggatgtctatgttaacaatgaatgggcaaccagtgttggggaaggagggagcttt
ggagaacttgctttgatttatggaacaccgagagcagccactgtcaaagcaaagacaaat
gtgaaattgtggggcatcgaccgagacagctatagaagaatcctcatgggaagcacactg
agaaagcggaagatgtatgaggaattccttagtaaagtctctattttagagtctctggac
aagtgggaacgtcttacggtagctgatgcattggaaccagtgcagtttgaagatgggcag
aagattgtggtgcagggagaaccaggggatgagttcttcattattttagaggggtcagct
gctgtgctacaacgtcggtcagaaaatgaagagtttgttgaagtgggaagattggggcct
tctgattattttggtgaaattgcactactgatgaatcgtcctcgtgctgccacagttgtt
gctcgtggccccttgaagtgcgttaagctggaccgacctagatttgaacgtgttcttggc
ccatgctcagacatcctcaaacgaaacatccagcagtacaacagttttgtgtcactgtct
gtctga

Protein Sequence

>5573 : length: 381
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE
EAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK
DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG
ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL
RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSA
AVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLG
PCSDILKRNIQQYNSFVSLSV



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