|
|
||
|
|
||
| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 55743 |
Name | CHFR |
Synonym | RNF116|RNF196;checkpoint with forkhead and ring finger domains;CHFR;checkpoint with forkhead and ring finger domains |
Definition | E3 ubiquitin-protein ligase CHFR|RING finger protein 196|checkpoint with forkhead and RING finger domains protein |
Position | 12q24.33 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 4 PubMed records as below. |
|
Evidence Status |
Description |
potential | "CHFR, a potential tumor suppressor, downregulates interleukin-8 through the inhibition of NF-kappaB." |
reviewed | "confirmed that the FHA domain of CHFR plays an important role in initiating a cell cycle arrest at G2/M, indicating a functional link exists between the anti-proliferative effects and checkpoint function of this tumor suppressor protein via this domain". |
reviewed | CHFR has a role as a tumor suppressor in breast cancer. |
reviewed | "CHFR might act as a tumor suppressor in at least some colorectal cancers and that CHFR methylation might, therefore, be a particular phenomenon of early colorectal cancer". |
| More detail of all 4 literatures about CHFR | |
|
External Links |
|
Links to Entrez Gene | 55743 |
Links to all GeneRIF Items | 55743 |
Links to iHOP | 55743 |
|
Sequence Information |
|
Nucleotide Sequence |
>55743 : length: 1995 atggagcggcccgaggaaggcaagcagtcgccgccgccgcagccctggggacggctcctg cgtctgggcgcggaggagggcgagccgcacgtcctcctgaggaagcgggagtggaccatc gggcggagacgaggttgcgacctttccttccccagcaataaactggtctctggagatcac tgtagaattgtagtggatgaaaaatcaggtcaggtgacactggaagataccagcaccagt ggaacagtgattaacaagctgaaggttgttaagaagcagacatgccctttacagactggg gatgtcatctacttggtgtacaggaagaatgaaccggaacacaacgtggcatacctctat gaatctttaagtgaaaagcaaggcatgacacaagaatcctttgaagctaacaaggaaaat gtgttccatgggaccaaagatacctcaggtgcaggtgcagggcgaggggccgatccccgg gtccctccgtcgtcgcccgccactcaggtgtgctttgaggaaccacagccatcaacatcg acgtcagacctcttccccacagcctcggcctcttccacggagccttctcctgcagggcga gagcgttcctccagttgtgggtctgggggtggtggcatctcccctaaaggaagtggtccc tctgtggcaagtgatgaagtctccagctttgcctcagctctcccagacagaaagactgcg tccttttcgtcgttggaaccccaggatcaggaggatttggagcccgtgaagaagaaaatg agaggagatggggaccttgacctgaacgggcagttgttggtcgcacaaccgcgtagaaat gcccaaaccgtccacgaggacgtcagagcagcggctgggaagccagacaagatggaggag acgctgacatgcatcatctgccaggacctgctgcacgactgcgtgagtttgcagccctgc atgcacacgttctgcgcggcttgctactcgggctggatggagcgctcgtccctgtgtcct acctgccgctgtcccgtggagcggatctgtaaaaaccacatcctcaacaacctcgtggaa gcatacctcatccagcatccagacaagagtcgcagtgaagaagatgtgcaaagtatggat gccaggaataaaatcactcaagacatgctgcagcccaaagtcaggcggtctttttctgat gaagaagggagttcagaggacctgctggagctgtcagacgttgacagtgagtcctcagac attagccagccatacgtcgtgtgccggcagtgtcctgagtacagaaggcaggcggcgcag cctccccactgcccagcacccgagggcgagccaggagccccacaggccctgggggatgca ccctccacgtccgtcagcctgacgacagcagtccaggattacgtgtgccctctgcaagga agccacgccctgtgcacctgctgcttccagcccatgcccgaccggagagcggagcgcgag caggacccgcgtgtcgcccctcagcagtgtgcggtctgcctgcagcctttctgccacctg tactggggctgcacccggaccggctgctacggctgcctggccccgttttgtgagctcaac ctgggtgacaagtgtctggacggcgtgctgaacaacaacagctacgagtcagacatcctg aagaattacctggcaaccagaggtttgacatggaaaaacatgttgaccgagagcctcgtg gctctccagcggggagtgtttctgctgtctgattacagagtcacgggagacaccgttctg tgttactgctgtggcctgcgcagcttccgtgagctgacctatcagtatcggcagaacatt cctgcttccgagttgccagtggccgtaacatcccgtcctgactgctactggggccgtaac tgccgcactcaggtgaaagctcaccacgccatgaaattcaatcatatctgtgaacagaca aggttcaaaaactaa |
Protein Sequence |
>55743 : length: 664 MERPEEGKQSPPPQPWGRLLRLGAEEGEPHVLLRKREWTIGRRRGCDLSFPSNKLVSGDH CRIVVDEKSGQVTLEDTSTSGTVINKLKVVKKQTCPLQTGDVIYLVYRKNEPEHNVAYLY ESLSEKQGMTQESFEANKENVFHGTKDTSGAGAGRGADPRVPPSSPATQVCFEEPQPSTS TSDLFPTASASSTEPSPAGRERSSSCGSGGGGISPKGSGPSVASDEVSSFASALPDRKTA SFSSLEPQDQEDLEPVKKKMRGDGDLDLNGQLLVAQPRRNAQTVHEDVRAAAGKPDKMEE TLTCIICQDLLHDCVSLQPCMHTFCAACYSGWMERSSLCPTCRCPVERICKNHILNNLVE AYLIQHPDKSRSEEDVQSMDARNKITQDMLQPKVRRSFSDEEGSSEDLLELSDVDSESSD ISQPYVVCRQCPEYRRQAAQPPHCPAPEGEPGAPQALGDAPSTSVSLTTAVQDYVCPLQG SHALCTCCFQPMPDRRAEREQDPRVAPQQCAVCLQPFCHLYWGCTRTGCYGCLAPFCELN LGDKCLDGVLNNNSYESDILKNYLATRGLTWKNMLTESLVALQRGVFLLSDYRVTGDTVL CYCCGLRSFRELTYQYRQNIPASELPVAVTSRPDCYWGRNCRTQVKAHHAMKFNHICEQT RFKN |