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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 5580 |
Name | PRKCD |
Synonym | MAY1|PKCD|nPKC-delta;protein kinase C, delta;PRKCD;protein kinase C, delta |
Definition | protein kinase C delta VIII|protein kinase C delta type |
Position | 3p21.31 |
Gene Type | protein-coding |
Source | Count: 3; Pubmed_search,Generif,UniProt |
Literature support | Count: 5 PubMed records as below. |
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Evidence Status |
Description |
reviewed | Regulation of tumor suppressor PDCD4 by novel protein kinase C isoforms. |
potential | "PKC-delta inhibits transformed keratinocyte growth by inducing apoptosis, and may function as a tumor suppressor in human SCCs where its loss in cells harboring activated ras could provide a growth advantage by conferring resistance to apoptosis". |
reviewed | Role of oncogenes and tumor suppressor genes in multistage carcinogenesis. |
reviewed | "Data indicate that all deltaWT tumors had activating mutations in KRAS, whereas only 69% of deltaKO tumors did, suggesting that PKCdelta acts as a tumor promoter downstream of oncogenic K-ras while acting as a tumor suppressor in other oncogenic contexts." |
reviewed | "vascular smooth muscle cell apoptosis proceeds through a pathway that involves PKCdelta, the intermediary p38 MAPK, and the downstream target tumor suppressor p53". |
| More detail of all 5 literatures about PRKCD | |
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Pathways and Diseases |
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Pathway | Vascular smooth muscle contraction;KEGG PATHWAY;hsa04270 |
Pathway | Apoptosis;Reactome;REACT:578 |
Pathway | Fc gamma R-mediated phagocytosis;KEGG PATHWAY;hsa04666 |
Pathway | Syndecan-4-mediated signaling events;PID Curated;200115 |
Pathway | Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722 |
Pathway | Signaling by GPCR;Reactome;REACT:14797 |
Pathway | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway;PANTHER;P00027 |
Pathway | ErbB1 downstream signaling;PID Curated;200113 |
Pathway | Alpha-synuclein signaling;PID Curated;200187 |
Pathway | 5HT2 type receptor mediated signaling pathway;PANTHER;P04374 |
Pathway | Muscarinic acetylcholine receptor 1 and 3 signaling pathway;PANTHER;P00042 |
Pathway | Thyrotropin-releasing hormone receptor signaling pathway;PANTHER;P04394 |
Pathway | PDGFR-beta signaling pathway;PID Curated;200127 |
Pathway | FGF signaling pathway;PANTHER;P00021 |
Pathway | LPA receptor mediated events;PID Curated;200011 |
Pathway | Trk receptor signaling mediated by PI3K and PLC-gamma;PID Curated;200183 |
Pathway | p53 pathway;PID Curated;200175 |
Pathway | Opioid Signalling;Reactome;REACT:15295 |
Pathway | hiv-1 nef: negative effector of fas and tnf;PID BioCarta;100144 |
Pathway | Endothelin signaling pathway;PANTHER;P00019 |
Pathway | Apoptotic cleavage of cellular proteins;PID Reactome;500270 |
Pathway | Alpha adrenergic receptor signaling pathway;PANTHER;P00002 |
Pathway | EGF receptor signaling pathway;PANTHER;P00018 |
Pathway | Endothelins;PID Curated;200004 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | IFN-gamma pathway;PID Curated;200110 |
Pathway | Hedgehog signaling events mediated by Gli proteins;PID Curated;200147 |
Pathway | Histamine H1 receptor mediated signaling pathway;PANTHER;P04385 |
Pathway | VEGF signaling pathway;PANTHER;P00056 |
Pathway | B cell activation;PANTHER;P00010 |
Pathway | Wnt signaling pathway;PANTHER;P00057 |
Pathway | Trk receptor signaling mediated by the MAPK pathway;PID Curated;200182 |
Pathway | Thromboxane A2 receptor signaling;PID Curated;200069 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | IGF1 pathway;PID Curated;200084 |
Pathway | GnRH signaling pathway;KEGG PATHWAY;hsa04912 |
Pathway | Alzheimer disease-amyloid secretase pathway;PANTHER;P00003 |
Pathway | Fc epsilon RI signaling pathway;KEGG PATHWAY;hsa04664 |
Pathway | Oxytocin receptor mediated signaling pathway;PANTHER;P04391 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes;PID Curated;200076 |
Pathway | Ceramide signaling pathway;PID Curated;200100 |
Pathway | Chemokine signaling pathway;KEGG PATHWAY;hsa04062 |
Pathway | Tight junction;KEGG PATHWAY;hsa04530 |
Pathway | Apoptosis signaling pathway;PANTHER;P00006 |
Pathway | IL6-mediated signaling events;PID Curated;200124 |
Pathway | Type II diabetes mellitus;KEGG PATHWAY;hsa04930 |
Pathway | Syndecan-2-mediated signaling events;PID Curated;200164 |
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External Links |
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Links to Entrez Gene | 5580 |
Links to all GeneRIF Items | 5580 |
Links to iHOP | 5580 |
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Sequence Information |
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Nucleotide Sequence |
>5580 : length: 2031 atggcgccgttcctgcgcatcgccttcaactcctatgagctgggctccctgcaggccgag gacgaggcgaaccagcccttctgtgccgtgaagatgaaggaggcgctcagcacagagcgt gggaaaacactggtgcagaagaagccgaccatgtatcctgagtggaagtcgacgttcgat gcccacatctatgaggggcgcgtcatccagattgtgctaatgcgggcagcagaggagcca gtgtctgaggtgaccgtgggtgtgtcggtgctggccgagcgctgcaagaagaacaatggc aaggctgagttctggctggacctgcagcctcaggccaaggtgttgatgtctgttcagtat ttcctggaggacgtggattgcaaacagtctatgcgcagtgaggacgaggccaagttccca acgatgaaccgccgcggagccatcaaacaggccaaaatccactacatcaagaaccatgag tttatcgccaccttctttgggcaacccaccttctgttctgtgtgcaaagactttgtctgg ggcctcaacaagcaaggctacaaatgcaggcaatgtaacgctgccatccacaagaaatgc atcgacaagatcatcggcagatgcactggcaccgcggccaacagccgggacactatattc cagaaagaacgcttcaacatcgacatgccgcaccgcttcaaggttcacaactacatgagc cccaccttctgtgaccactgcggcagcctgctctggggactggtgaagcagggattaaag tgtgaagactgcggcatgaatgtgcaccataaatgccgggagaaggtggccaacctctgc ggcatcaaccagaagcttttggctgaggccttgaaccaagtcacccagagagcctcccgg agatcagactcagcctcctcagagcctgttgggatatatcagggtttcgagaagaagacc ggagttgctggggaggacatgcaagacaacagtgggacctacggcaagatctgggagggc agcagcaagtgcaacatcaacaacttcatcttccacaaggtcctgggcaaaggcagcttc gggaaggtgctgcttggagagctgaagggcagaggagagtactttgccatcaaggccctc aagaaggatgtggtcctgatcgacgacgacgtggagtgcaccatggttgagaagcgggtg ctgacacttgccgcagagaatccctttctcacccacctcatctgcaccttccagaccaag gaccacctgttctttgtgatggagttcctcaacgggggggacctgatgtaccacatccag gacaaaggccgctttgaactctaccgtgccacgttttatgccgctgagataatgtgtgga ctgcagtttctacacagcaagggcatcatttacagggacctcaaactggacaatgtgctg ctggaccgggatggccacatcaagattgccgactttgggatgtgcaaagagaacatattc ggggagagccgggccagcaccttctgcggcacccctgactatatcgcccctgagatccta cagggcctgaagtacacattctctgtggactggtggtctttcggggtccttctgtacgag atgctcattggccagtcccccttccatggtgatgatgaggatgaactcttcgagtccatc cgtgtggacacgccacattatccccgctggatcaccaaggagtccaaggacatcctggag aagctctttgaaagggaaccaaccaagaggctgggagtgaccggaaacatcaaaatccac cccttcttcaagaccataaactggactctgctggaaaagcggaggttggagccacctttc aggcccaaagtgaagtcacccagagactacagtaactttgaccaggagttcctgaacgag aaggcgcgcctctcctacagcgacaagaacctcatcgactccatggaccagtctgcattc gctggcttctcctttgtgaaccccaaattcgagcacctcctggaagattga |
Protein Sequence |
>5580 : length: 676 MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF AGFSFVNPKFEHLLED |