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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 5580 |
Name | PRKCD |
Synonymous | MAY1|PKCD|nPKC-delta;protein kinase C, delta;PRKCD;protein kinase C, delta |
Definition | protein kinase C delta VIII|protein kinase C delta type |
Position | 3p21.31 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
DNA-PKcs(h) + PKCdelta(h) <==> DNA-PKcs(h):PKCdelta(h) (binding) | PKCdelta(h) --Caspase-3(h)--> PKCdelta-CF(h) + protein remnants (processing) | p73beta(h) + PKCdelta(h) <==> p73beta(h):PKCdelta(h) (binding) | Abl(m.s.) + PKCdelta(h) <==> Abl(m.s.):PKCdelta(h) (binding) | PKCdelta(h) + ATP --> PKCdelta(h){pS660} + ADP (phosphorylation; automodification) | PKCdelta(h) + PKCalpha(h) <==> PKCdelta(h):PKCalpha(h) (binding) | PKCdelta(h) + proCaspase-3(h) <==> PKCdelta(h):proCaspase-3(h) (binding) | PKCdelta(h) --Caspase-3(h)--> PKCdelta-p40(h) + protein remnants (cleavage) | Abl(h) + PKCdelta(h) <==> Abl(h):PKCdelta(h) (binding) | PKCdelta(h) + Bcl-X(h) <==> PKCdelta(h):Bcl-X(h) (binding) | PKCdelta(h) + ATP --> PKCdelta(h){pY} + ADP (phosphorylation) | PKCdelta(h) + ATP --Abl(h)--> PKCdelta(h){pY311} + ADP (phosphorylation) | p53(h) + PKCdelta(h) <==> p53(h):PKCdelta(h) (binding) | PKCdelta(h) + p53DINP1(h) <==> PKCdelta(h):p53DINP1(h) (binding) | PKCdelta(h) --> PKCdelta(h) (translocation) | PKCdelta(h) + IKK-alpha(h) <==> PKCdelta(h):IKK-alpha(h) (binding) | PKCdelta(h) + ATP --> PKCdelta(h){pT507} + ADP (phosphorylation) | PKCdelta(h) --> c-Jun(h){p} (increase of phosphorylation) | PKCdelta(h) + Lyn(h) <==> PKCdelta(h):Lyn(h) (binding) | PKCdelta(h) + MEKK1(h) <==> PKCdelta(h):MEKK1(h) (binding) | Prkcm(h) + PKCdelta(h) <==> Prkcm(h):PKCdelta(h) (binding) | PKCdelta(h) + ATP --> PKCdelta(h){pS645} + ADP (phosphorylation) | PKCdelta(h) + ATP --> PKCdelta(h){p} + ADP (phosphorylation) | fTnT(r) + PKCdelta(h) <==> fTnT(r):PKCdelta(h) (binding) | STAT1(h) + PKCdelta(h) <==> STAT1(h):PKCdelta(h) (binding) | PKCdelta(h) --> PKCdelta-p40(h) + protein remnants (cleavage) | PRKCD(h) --> PKCdelta(h) (expression). | PKCdelta(h) --> PKCdelta(h) (translocation) | phlpp1(h) --/ PKCdelta(h) (decrease of abundance) | phlpp2(h) --/ PKCdelta(h) (decrease of abundance) | cTnI(b):cTnT(b):TNNC(b) + 2 ATP --PKCdelta(h)--> cTnT(b){p}:cTnI(b){p}:TNNC(b) + 2 ADP (phosphorylation) | cTnI(b) + 2 ATP --PKCdelta(h)--> cTnI(b){pS78}{pT144} + 2 ADP (phosphorylation) | cTnT(b) + 3 ATP --PKCdelta(h)--> cTnT(b){pS194}{pT199}{pT280} + 3 ADP (phosphorylation) | cTnI(m) + 3 ATP --PKCdelta(h)--> cTnI(m){pS43}{pS45}{pT144} + 3 ADP (phosphorylation) | cTnI(r) + 3 ATP --PKCdelta(h)--> cTnI(r){pS43}{pS45}{pT144} + 3 ADP (phosphorylation) | proCaspase-3(h) + ATP --PKCdelta(h)--> proCaspase-3(h){p} + ADP (phosphorylation) | p21Cip1(h) + ATP --PKCdelta(h)--> p21Cip1(h){pS146} + ADP (phosphorylation) | p53(h) + ATP --PKCdelta(h)--> p53(h){pS46} + ADP (phosphorylation) | histone H1(m.s.) + ATP --PKCdelta(h)--> histone H1(m.s.){p} + ADP (phosphorylation) | STAT1(m.s.) + ATP --PKCdelta(h)--> STAT1(m.s.){pS727} + ADP (phosphorylation) | PRKCD(h) --> PKCdelta-xbb1(h) (expression). | histone H3(m.s.) + ATP --PKCdelta-xbb1(h)--> histone H3(m.s.){pT46} + ADP (phosphorylation) | PKCdelta(h) --> Cdk2(m.s.):p21Cip1(h) (decrease of binding) | PKCdelta(h) --> Cdk2(h):p21Cip1(h) (decrease of binding) | PKCdelta(h) + p53(h) <==> PKCdelta(h):p53(h) (binding) | PKCdelta(h) + p53DINP1(m.s.) <==> PKCdelta(h):p53DINP1(m.s.) (binding) | PKCdelta(h) + IKK-alpha(m.s.) <==> PKCdelta(h):IKK-alpha(m.s.) (binding) | PKCdelta(h) --> IKK-alpha(m.s.){p} (increase of phosphorylation) | PKCdelta(h) + PKD2(h) <==> PKCdelta(h):PKD2(h) (binding) | PKCdelta(h) + trim41-isoform2(h) <==> PKCdelta(h):trim41-isoform2(h) (binding) | PRKCD(h) --> PKCdelta(h) (expression). | p300(m.s.) + ATP --PKCdelta(h)--> p300(m.s.){pS89} + ADP (phosphorylation) | p21Cip1(h) + ATP --PKCdelta(h)--> p21Cip1(h){pS146} + ADP (phosphorylation) | p53(h) + ATP --PKCdelta(h)--> p53(h){pS46} + ADP (phosphorylation) | CYP7(h) + ATP --PKCdelta(h)--> CYP7(h){p} + ADP (phosphorylation) | STAT1(h) + ATP --PKCdelta(h)--> STAT1(h){pS727} + ADP (phosphorylation) | CLIC1(m.s.) + ATP --PKCdelta(h)--> CLIC1(m.s.){p} + ADP (phosphorylation) | CLIC4(m.s.) + ATP --PKCdelta(h)--> CLIC4(m.s.){p} + ADP (phosphorylation) |
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Post Transcriptional Modification From dbPTM | | Top | |
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Location (AA) |
PTM type |
Literature |
Database |
507 | Phosphothreonine (by PDPK1) (Bysimilarity). | Swiss-Prot 53.0 | 645 | Phosphoserine (Potential). | Swiss-Prot 53.0 | 664 | Phosphoserine. | Swiss-Prot 53.0 | 187 | Phosphotyrosine | 96421649;15302935 | Phospho.ELM 6.0 | 507 | Phosphothreonine (PDK-1) | 9748166;15302935 | Phospho.ELM 6.0 | 52 | Phosphotyrosine | 15302935 | Phospho.ELM 6.0 | 64 | Phosphotyrosine | 15302935 | Phospho.ELM 6.0 | 155 | Phosphotyrosine | 15302935 | Phospho.ELM 6.0 | 313 | Phosphotyrosine | 15302935 | Phospho.ELM 6.0 | 645 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 664 | Phosphoserine | 15302935 | Phospho.ELM 6.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
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Chromosome |
Location |
Source |
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chr3 |
Promoter: 53168763 - 53170763 | Agilent_014791 |
chr3 |
Promoter: 53168763 - 53170763 | GSE27584 |
chr3 |
Promoter: 53168763 - 53170763 | GSE27584 |
chr3 |
Promoter: 53168763 - 53170763 | Agilent_014791_44K |
chr3 |
Promoter: 53168763 - 53170763 | Agilent_014791_44K |