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General information | Expression | Regulation | Mutation | Interaction |
Basic Information |
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Gene ID | 580 |
Name | BARD1 |
Synonym | -;BRCA1 associated RING domain 1;BARD1;BRCA1 associated RING domain 1 |
Definition | BARD-1|BRCA1 associated RING domain 1 isoform alfa|BRCA1 associated RING domain 1 isoform beta|BRCA1 associated RING domain 1 isoform delta|BRCA1 associated RING domain 1 isoform epsilon|BRCA1 associated RING domain 1 isoform eta|BRCA1 associated RING dom |
Position | 2q34-q35 |
Gene Type | protein-coding |
Source | Count: 3; Pubmed_search,TAG,Generif |
Literature support | Count: 4 PubMed records as below. |
Evidence Status |
Description |
reviewed | Hyperphosphorylation of the BARD1 tumor suppressor in mitotic cells. |
reviewed | "differential gene expression of Bard1, a tumor suppressor gene, plays a significant role in the proliferation of breast cancer". |
reviewed | "The remarkable similarities between the mammary carcinomas of Bard1-, Brca1-, and Bard1/Brca1-mutant mice indicate that the tumor suppressor activities of both genes are mediated through the BRCA1/BARD1 heterodimer." |
reviewed | Structural requirements for the BARD1 tumor suppressor in chromosomal stability and homology-directed DNA repair. |
More detail of all 4 literatures about BARD1 | |
Pathways and Diseases |
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Pathway | BARD1 signaling events;PID Curated;200174 |
Pathway | brca1 dependent ub ligase activity;PID BioCarta;100232 |
Disease | Female reproductive cancer;FunDO |
Disease | breast cancer;GAD |
Disease | neuroblastoma (high-risk);GAD |
Disease | Neuroblastoma (high-risk);NHGRI |
Disease | CANCER;GAD |
Disease | breast cancer breast cancer, male colorectal cancer ovarian cancer prostate cancer;GAD |
Disease | Cancer;FunDO |
Disease | Breast cancer, susceptibility to;OMIM |
External Links |
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Links to Entrez Gene | 580 |
Links to all GeneRIF Items | 580 |
Links to iHOP | 580 |
Sequence Information |
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Nucleotide Sequence |
>580 : length: 2334 atgccggataatcggcagccgaggaaccggcagccgaggatccgctccgggaacgagcct cgttccgcgcccgccatggaaccggatggtcgcggtgcctgggcccacagtcgcgccgcg ctcgaccgcctggagaagctgctgcgctgctcgcgttgtactaacattctgagagagcct gtgtgtttaggaggatgtgagcacatcttctgtagtaattgtgtaagtgactgcattgga actggatgtccagtgtgttacaccccggcctggatacaagacttgaagataaatagacaa ctggacagcatgattcaactttgtagtaagcttcgaaatttgctacatgacaatgagctg tcagatttgaaagaagataaacctaggaaaagtttgtttaatgatgcaggaaacaagaag aattcaattaaaatgtggtttagccctcgaagtaagaaagtcagatatgttgtgagtaaa gcttcagtgcaaacccagcctgcaataaaaaaagatgcaagtgctcagcaagactcatat gaatttgtttccccaagtcctcctgcagatgtttctgagagggctaaaaaggcttctgca agatctggaaaaaagcaaaaaaagaaaactttagctgaaatcaaccaaaaatggaattta gaggcagaaaaagaagatggtgaatttgactccaaagaggaatctaagcaaaagctggta tccttctgtagccaaccatctgttatctccagtcctcagataaatggtgaaatagactta ctagcaagtggctccttgacagaatctgaatgttttggaagtttaactgaagtctcttta ccattggctgagcaaatagagtctccagacactaagagcaggaatgaagtagtgactcct gagaaggtctgcaaaaattatcttacatctaagaaatctttgccattagaaaataatgga aaacgtggccatcacaatagactttccagtcccatttctaagagatgtagaaccagcatt ctgagcaccagtggagattttgttaagcaaacggtgccctcagaaaatataccattgcct gaatgttcttcaccaccttcatgcaaacgtaaagttggtggtacatcagggaggaaaaac agtaacatgtccgatgaattcattagtctttcaccaggtacaccaccttctacattaagt agttcaagttacaggcgagtgatgtctagtccctcagcaatgaagctgttgcccaatatg gctgtgaaaagaaatcatagaggagagactttgctccatattgcttctattaagggcgac ataccttctgttgaataccttttacaaaatggaagtgatccaaatgttaaagaccatgct ggatggacaccattgcatgaagcttgcaatcatgggcacctgaaggtagtggaattattg ctccagcataaggcattggtgaacaccaccgggtatcaaaatgactcaccacttcacgat gcagccaagaatgggcatgtggatatagtcaagctgttactttcctatggagcctccaga aatgctgttaatatatttggtctgcggcctgtcgattatacagatgatgaaagtatgaaa tcgctattgctgctaccagagaagaatgaatcatcctcagctagccactgctcagtaatg aacactgggcagcgtagggatggacctcttgtacttataggcagtgggctgtcttcagaa caacagaaaatgctcagtgagcttgcagtaattcttaaggctaaaaaatatactgagttt gacagtacagtaactcatgttgttgttcctggtgatgcagttcaaagtaccttgaagtgt atgcttgggattctcaatggatgctggattctaaaatttgaatgggtaaaagcatgtcta cgaagaaaagtatgtgaacaggaagaaaagtatgaaattcctgaaggtccacgcagaagc aggctcaacagagaacagctgttgccaaagctgtttgatggatgctacttctatttgtgg ggaaccttcaaacaccatccaaaggacaaccttattaagctcgtcactgcaggtgggggc cagatcctcagtagaaagcccaagccagacagtgacgtgactcagaccatcaatacagtc gcataccatgcgagacccgattctgatcagcgcttctgcacacagtatatcatctatgaa gatttgtgtaattatcacccagagagggttcggcagggcaaagtctggaaggctccttcg agctggtttatagactgtgtgatgtcctttgagttgcttcctcttgacagctga |
Protein Sequence |
>580 : length: 777 MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREP VCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNEL SDLKEDKPRKSLFNDAGNKKNSIKMWFSPRSKKVRYVVSKASVQTQPAIKKDASAQQDSY EFVSPSPPADVSERAKKASARSGKKQKKKTLAEINQKWNLEAEKEDGEFDSKEESKQKLV SFCSQPSVISSPQINGEIDLLASGSLTESECFGSLTEVSLPLAEQIESPDTKSRNEVVTP EKVCKNYLTSKKSLPLENNGKRGHHNRLSSPISKRCRTSILSTSGDFVKQTVPSENIPLP ECSSPPSCKRKVGGTSGRKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNM AVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELL LQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMK SLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEF DSTVTHVVVPGDAVQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRS RLNREQLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTV AYHARPDSDQRFCTQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS |
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