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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 5933 |
Name | RBL1 |
Synonym | CP107|PRB1|p107;retinoblastoma-like 1 (p107);RBL1;retinoblastoma-like 1 (p107) |
Definition | 107 kDa retinoblastoma-associated protein|cellular protein 107|retinoblastoma-like protein 1 |
Position | 20q11.2 |
Gene Type | protein-coding |
Source | Count: 3; Pubmed_search,Generif,UniProt |
Literature support | Count: 7 PubMed records as below. |
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Evidence Status |
Description |
reviewed | Skip interacts with the retinoblastoma tumor suppressor and inhibits its transcriptional repression activity. |
reviewed | The p107 tumor suppressor induces stable E2F DNA binding to repress target promoters. |
potential | "Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function." |
reviewed | tumor suppressor gene expression during normal and pathologic myocardial growth. |
reviewed | data demonstrate that p107 behaves as a tumor suppressor in epidermis in the absence of pRb and suggest novel tumor-suppressive roles for p107 in the context of functional p53 and activated Ras. |
reviewed | Compensation by tumor suppressor genes during retinal development in mice and humans. |
reviewed | Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130. |
| More detail of all 7 literatures about RBL1 | |
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Pathways and Diseases |
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Pathway | E2F transcription factor network;PID Curated;200027 |
Pathway | cyclins and cell cycle regulation;PID BioCarta;100207 |
Pathway | mets affect on macrophage differentiation;PID BioCarta;100169 |
Pathway | Regulation of nuclear SMAD2/3 signaling;PID Curated;200002 |
Pathway | p53 pathway feedback loops 2;PANTHER;P04398 |
Pathway | Cell cycle;KEGG PATHWAY;hsa04110 |
Pathway | TGF-beta signaling pathway;KEGG PATHWAY;hsa04350 |
Pathway | Validated targets of C-MYC transcriptional repression;PID Curated;200171 |
Disease | Adenoma of thyroid;FunDO |
Disease | Breast cancer;FunDO |
Disease | Thyroid cancer;FunDO |
Disease | Papillary cancer;FunDO |
Disease | Prostate cancer;FunDO |
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External Links |
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Links to Entrez Gene | 5933 |
Links to all GeneRIF Items | 5933 |
Links to iHOP | 5933 |
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Sequence Information |
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Nucleotide Sequence |
>5933 : length: 3207 atgttcgaggacaagccccacgctgagggggcggcggtggtcgccgcagccggggaggcg ctacaggccctgtgccaggagctgaacctggacgaggggagcgcggccgaagccctggac gactttactgccatccgaggcaactacagcctagagggagaagttacacactggttggca tgttcattatatgttgcatgccgcaaaagcattattcccacggttggaaagggtatcatg gaaggcaactgtgtttcacttaccagaatactacgttcagctaaattaagtttaatacaa ttttttagtaaaatgaagaaatggatggacatgtcaaatctaccacaagaatttcgtgaa cgtatagaaaggctagagagaaattttgaggtgtctactgtaatattcaaaaaatatgag ccaatttttttagatatatttcaaaatccatatgaagaaccaccaaagttaccacgaagc cggaagcagaggaggattccttgcagtgttaaggatctgtttaatttctgttggacactt tttgtttatactaagggtaattttcggatgattggggatgacttagtaaactcttatcat ttacttctatgctgcttggatctgatttttgccaatgcgattatgtgcccaaatagacaa gacttgctaaatccatcatttaaaggtttaccatctgattttcatactgctgactttacg gcttctgaagagccaccctgcatcattgctgtactgtgtgaactgcatgatggacttctc gtagaagcaaaaggaataaaggagcactactttaagccatatatttcaaaactctttgac aggaagatattaaaaggagaatgcctcctggacctttcaagttttactgataatagcaaa gcagtgaataaggagtatgaagagtatgttctaactgttggtgattttgatgagaggatc tttttgggagcagacgcagaagaggaaattggaacacctcgaaagttcactcgtgacacc ccattagggaaactgacagcacaggctaatgtggagtataaccttcaacagcactttgaa aaaaaaaggtcatttgcaccttctaccccactgaccggacggagatatttacgagaaaaa gaagcagtcattactcctgttgcatcagccacccaaagtgtgagccggttacagagtatt gtggctggtctgaaaaatgcaccaagtgaccaacttataaatatttttgaatcttgtgtg cgtaatcctgtggaaaacattatgaaaatactaaaaggaataggagagactttctgtcaa cactatactcaatcaacagatgaacagccaggatctcacatagactttgctgtaaacaga ctaaagctggcagaaattttgtattataaaatactagagactgtaatggttcaggaaaca cgaagacttcatggaatggacatgtcagttcttttagagcaagatatatttcatcgttcc ttgatggcttgttgtttggaaattgtgctctttgcctatagctcacctcgtacttttcct tggattattgaagttctcaacttgcaaccattttacttttataaggttattgaggtggtg atccgctcagaagaggggctctcaagggacatggtgaaacacctaaacagcattgaagaa cagattttggagagtttagcatggagtcacgattctgcactgtgggaggctctccaggtt tctgcaaacaaagttcctacctgtgaagaagttatattcccaaataactttgaaacagga aatggaggaaatgtgcagggacatcttcccctgatgccaatgtctcctctaatgcaccca agagtcaaggaagttcgaactgacagtgggagtcttcgaagagatatgcaaccattgtct ccaatttctgtccatgaacgctacagttctcctaccgcagggagtgctaagagaagactc tttggagaggaccccccaaaggaaatgcttatggacaagatcataacagaaggaacaaaa ttgaaaatcgctccttcttcaagcattactgctgaaaatgtatcaattttacctggtcaa actcttctaacaatggccacagccccagtaacaggaacaacaggacataaagttacaatt ccattacatggtgtcgcaaatgatgctggagagatcacactgatacctctttccatgaat acaaatcaggagtccaaagtcaagagtcctgtatcacttactgctcattcattaattggt gcttctccaaaacagaccaatctgactaaagcacaagaggtacattcaactggaataaac aggccaaagagaactgggtccttagcactattttacagaaaggtctatcatttggcaagt gtacgcttacgtgatctatgtctaaaactggatgtttcaaatgagttacgaaggaagata tggacgtgttttgaattcactttagttcactgtcctgatctaatgaaagacaggcatttg gatcagctcctcctttgtgccttttatatcatggcaaaggtaacaaaagaagaaagaact tttcaagaaattatgaaaagttataggaatcagccccaagctaatagtcacgtatataga agtgttctgctgaaaagtattccaagagaagttgtggcatataataaaaatataaatgat gactttgaaatgatagattgtgacttagaagatgctacaaaaacacctgactgttccagt ggaccagtgaaagaggaaagaggtgatcttataaaattttacaatacaatatatgtagga agagtgaagtcatttgcactgaaatacgacttggcgaatcaggaccatatgatggatgct ccaccactctctccttttccacatattaaacaacagccaggctcaccacgccgcatttcc cagcagcactccatttatatttccccgcacaagaatgggtcaggccttacaccaagaagc gctctgctgtacaagttcaatggcagcccttctaagagtttgaaagatatcaacaacatg ataaggcaaggtgagcagagaaccaagaagcgagtaatagccatcgatagtgatgcagaa tcccctgccaaacgcgtctgtcaagaaaatgatgacgttttactgaaacgactacaggat gttgtcagtgaaagagcaaatcattaa |
Protein Sequence |
>5933 : length: 1068 MFEDKPHAEGAAVVAAAGEALQALCQELNLDEGSAAEALDDFTAIRGNYSLEGEVTHWLA CSLYVACRKSIIPTVGKGIMEGNCVSLTRILRSAKLSLIQFFSKMKKWMDMSNLPQEFRE RIERLERNFEVSTVIFKKYEPIFLDIFQNPYEEPPKLPRSRKQRRIPCSVKDLFNFCWTL FVYTKGNFRMIGDDLVNSYHLLLCCLDLIFANAIMCPNRQDLLNPSFKGLPSDFHTADFT ASEEPPCIIAVLCELHDGLLVEAKGIKEHYFKPYISKLFDRKILKGECLLDLSSFTDNSK AVNKEYEEYVLTVGDFDERIFLGADAEEEIGTPRKFTRDTPLGKLTAQANVEYNLQQHFE KKRSFAPSTPLTGRRYLREKEAVITPVASATQSVSRLQSIVAGLKNAPSDQLINIFESCV RNPVENIMKILKGIGETFCQHYTQSTDEQPGSHIDFAVNRLKLAEILYYKILETVMVQET RRLHGMDMSVLLEQDIFHRSLMACCLEIVLFAYSSPRTFPWIIEVLNLQPFYFYKVIEVV IRSEEGLSRDMVKHLNSIEEQILESLAWSHDSALWEALQVSANKVPTCEEVIFPNNFETG NGGNVQGHLPLMPMSPLMHPRVKEVRTDSGSLRRDMQPLSPISVHERYSSPTAGSAKRRL FGEDPPKEMLMDKIITEGTKLKIAPSSSITAENVSILPGQTLLTMATAPVTGTTGHKVTI PLHGVANDAGEITLIPLSMNTNQESKVKSPVSLTAHSLIGASPKQTNLTKAQEVHSTGIN RPKRTGSLALFYRKVYHLASVRLRDLCLKLDVSNELRRKIWTCFEFTLVHCPDLMKDRHL DQLLLCAFYIMAKVTKEERTFQEIMKSYRNQPQANSHVYRSVLLKSIPREVVAYNKNIND DFEMIDCDLEDATKTPDCSSGPVKEERGDLIKFYNTIYVGRVKSFALKYDLANQDHMMDA PPLSPFPHIKQQPGSPRRISQQHSIYISPHKNGSGLTPRSALLYKFNGSPSKSLKDINNM IRQGEQRTKKRVIAIDSDAESPAKRVCQENDDVLLKRLQDVVSERANH |