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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 639 |
Name | PRDM1 |
Synonym | BLIMP1|PRDI-BF1;PR domain containing 1, with ZNF domain;PRDM1;PR domain containing 1, with ZNF domain |
Definition | B-lymphocyte-induced maturation protein 1|BLIMP-1|PR domain zinc finger protein 1|PRDI-binding factor-1|beta-interferon gene positive-regulatory domain I binding factor |
Position | 6q21 |
Gene Type | protein-coding |
Source | Count: 3; Pubmed_search,TAG,Generif |
Literature support | Count: 9 PubMed records as below. |
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Evidence Status |
Description |
reviewed | PRDM1 is a tumor suppressor gene in natural killer cell malignancies. |
potential | Identification of FOXO3 and PRDM1 as tumor-suppressor gene candidates in NK-cell neoplasms by genomic and functional analyses. |
potential | "Blimp-1 is located in chromosome 6q21-22.1, a region frequently deleted in several tumors including lymphoid malignancies and has been supposed to be a candidate of tumor suppressor gene". |
reviewed | Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies. |
reviewed | PRDM1 may be a tumor suppressor in some primary central nervous system lymphoma and contribute to lymphomagenesis by impairing terminal differentiation. |
reviewed | "Blimp1 is a tumor suppressor gene, whose inactivation may contribute to lymphomagenesis by blocking post-germinal center differentiation of B cells toward plasma cells." |
potential | identifies PRDM1 inactivation as a recurrent genetic defect in diffuse large B-cell lymphomas cells and establishes PRDM1 as a potential tumor suppressor gene. |
reviewed | "both NF-kappaB signaling, as an oncogenic event, and BLIMP1, as a tumor suppressor, play causal roles in the pathogenesis of ABC-DLBCL." |
reviewed | BLIMP1 is a tumor suppressor gene frequently disrupted in activated B cell-like diffuse large B cell lymphoma. |
| More detail of all 9 literatures about PRDM1 | |
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Pathways and Diseases |
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Pathway | Direct p53 effectors;PID Curated;200101 |
Disease | Bacterial infection;FunDO |
Disease | IMMUNE;GAD |
Disease | Lymphoma;FunDO |
Disease | Congenital abnormality;FunDO |
Disease | Systemic lupus erythematosus;NHGRI |
Disease | systemic lupus erythematosus;GAD |
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External Links |
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Links to Entrez Gene | 639 |
Links to all GeneRIF Items | 639 |
Links to iHOP | 639 |
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Sequence Information |
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Nucleotide Sequence |
>639 : length: 2478 atgttggatatttgcttggaaaaacgtgtgggtacgaccttggctgcccccaagtgtaac tccagcactgtgaggtttcagggattggcagaggggaccaaggggaccatgaaaatggac atggaggatgcggatatgactctgtggacagaggctgagtttgaagagaagtgtacatac attgtgaacgaccacccctgggattctggtgctgatggcggtacttcggttcaggcggag gcatccttaccaaggaatctgcttttcaagtatgccaccaacagtgaagaggttattgga gtgatgagtaaagaatacataccaaagggcacacgttttggacccctaataggtgaaatc tacaccaatgacacagttcctaagaacgccaacaggaaatatttttggaggatctattcc agaggggagcttcaccacttcattgacggctttaatgaagagaaaagcaactggatgcgc tatgtgaatccagcacactctccccgggagcaaaacctggctgcgtgtcagaacgggatg aacatctacttctacaccattaagcccatccctgccaaccaggaacttcttgtgtggtat tgtcgggactttgcagaaaggcttcactacccttatcccggagagctgacaatgatgaat ctcacacaaacacagagcagtctaaagcaaccgagcactgagaaaaatgaactctgccca aagaatgtcccaaagagagagtacagcgtgaaagaaatcctaaaattggactccaacccc tccaaaggaaaggacctctaccgttctaacatttcacccctcacatcagaaaaggacctc gatgactttagaagacgtgggagccccgaaatgcccttctaccctcgggtcgtttacccc atccgggcccctctgccagaagactttttgaaagcttccctggcctacgggatcgagaga cccacgtacatcactcgctcccccattccatcctccaccactccaagcccctctgcaaga agcagccccgaccaaagcctcaagagctccagccctcacagcagccctgggaatacggtg tcccctgtgggccccggctctcaagagcaccgggactcctacgcttacttgaacgcgtcc tacggcacggaaggtttgggctcctaccctggctacgcacccctgccccacctcccgcca gctttcatcccctcgtacaacgctcactaccccaagttcctcttgcccccctacggcatg aattgtaatggcctgagcgctgtgagcagcatgaatggcatcaacaactttggcctcttc ccgaggctgtgccctgtctacagcaatctcctcggtgggggcagcctgccccaccccatg ctcaaccccacttctctcccgagctcgctgccctcagatggagcccggaggttgctccag ccggagcatcccagggaggtgcttgtcccggcgccccacagtgccttctcctttaccggg gccgccgccagcatgaaggacaaggcctgtagccccacaagcgggtctcccacggcggga acagccgccacggcagaacatgtggtgcagcccaaagctacctcagcagcgatggcagcc cccagcagcgacgaagccatgaatctcattaaaaacaaaagaaacatgaccggctacaag acccttccctacccgctgaagaagcagaacggcaagatcaagtacgaatgcaacgtttgc gccaagactttcggccagctctccaatctgaaggtccacctgagagtgcacagtggagaa cggcctttcaaatgtcagacttgcaacaagggctttactcagctcgcccacctgcagaaa cactacctggtacacacgggagaaaagccacatgaatgccaggtctgccacaagagattt agcagcaccagcaatctcaagacccacctgcgactccattctggagagaaaccataccaa tgcaaggtgtgccctgccaagttcacccagtttgtgcacctgaaactgcacaagcgtctg cacacccgggagcggccccacaagtgctcccagtgccacaagaactacatccatctctgt agcctcaaggttcacctgaaagggaactgcgctgcggccccggcgcctgggctgcccttg gaagatctgacccgaatcaatgaagaaatcgagaagtttgacatcagtgacaatgctgac cggctcgaggacgtggaggatgacatcagtgtgatctctgtagtggagaaggaaattctg gccgtggtcagaaaagagaaagaagaaactggcctgaaagtgtctttgcaaagaaacatg gggaatggactcctctcctcagggtgcagcctttatgagtcatcagatctacccctcatg aagttgcctcccagcaacccactacctctggtacctgtaaaggtcaaacaagaaacagtt gaaccaatggatccttaa |
Protein Sequence |
>639 : length: 825 MLDICLEKRVGTTLAAPKCNSSTVRFQGLAEGTKGTMKMDMEDADMTLWTEAEFEEKCTY IVNDHPWDSGADGGTSVQAEASLPRNLLFKYATNSEEVIGVMSKEYIPKGTRFGPLIGEI YTNDTVPKNANRKYFWRIYSRGELHHFIDGFNEEKSNWMRYVNPAHSPREQNLAACQNGM NIYFYTIKPIPANQELLVWYCRDFAERLHYPYPGELTMMNLTQTQSSLKQPSTEKNELCP KNVPKREYSVKEILKLDSNPSKGKDLYRSNISPLTSEKDLDDFRRRGSPEMPFYPRVVYP IRAPLPEDFLKASLAYGIERPTYITRSPIPSSTTPSPSARSSPDQSLKSSSPHSSPGNTV SPVGPGSQEHRDSYAYLNASYGTEGLGSYPGYAPLPHLPPAFIPSYNAHYPKFLLPPYGM NCNGLSAVSSMNGINNFGLFPRLCPVYSNLLGGGSLPHPMLNPTSLPSSLPSDGARRLLQ PEHPREVLVPAPHSAFSFTGAAASMKDKACSPTSGSPTAGTAATAEHVVQPKATSAAMAA PSSDEAMNLIKNKRNMTGYKTLPYPLKKQNGKIKYECNVCAKTFGQLSNLKVHLRVHSGE RPFKCQTCNKGFTQLAHLQKHYLVHTGEKPHECQVCHKRFSSTSNLKTHLRLHSGEKPYQ CKVCPAKFTQFVHLKLHKRLHTRERPHKCSQCHKNYIHLCSLKVHLKGNCAAAPAPGLPL EDLTRINEEIEKFDISDNADRLEDVEDDISVISVVEKEILAVVRKEKEETGLKVSLQRNM GNGLLSSGCSLYESSDLPLMKLPPSNPLPLVPVKVKQETVEPMDP |