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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 6416 |
Name | MAP2K4 |
Synonym | JNKK|JNKK1|MAPKK4|MEK4|MKK4|PRKMK4|SAPKK-1|SAPKK1|SEK1|SERK1;mitogen-activated protein kinase kinase 4;MAP2K4;mitogen-activated protein kinase kinase 4 |
Definition | JNK activating kinase 1|JNK-activated kinase 1|JNK-activating kinase 1|MAP kinase kinase 4|MAPK/ERK kinase 4|MAPKK 4|MEK 4|SAPK kinase 1|SAPK/ERK kinase 1|c-Jun N-terminal kinase kinase 1|dual specificity mitogen-activated protein kinase kinase 4|stress-a |
Position | 17p11.2 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 7 PubMed records as below. |
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Evidence Status |
Description |
reviewed | "Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene." |
potential | Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor. |
reviewed | Map2k4 functions as a tumor suppressor in lung adenocarcinoma and inhibits tumor cell invasion by decreasing peroxisome proliferator-activated receptor γ2 expression. |
reviewed | Analysis of the mitogen-activated protein kinase kinase 4 (MAP2K4) tumor suppressor gene in ovarian cancer. |
reviewed | These results indicated that MKK4 acts as a tumor suppressor and may represent an important therapeutic target for the treatment of ovarian cancer. |
reviewed | Negative regulation of JNK signaling by the tumor suppressor CYLD. |
potential | Map2k4 functions as a tumor suppressor in lung adenocarcinoma and inhibits tumor cell invasion by decreasing peroxisome proliferator-activated receptor γ2 expression. |
reviewed | Disruption of MKK4 signaling reveals its tumor suppressor role in embryonic stem cells. |
| More detail of all 7 literatures about MAP2K4 | |
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Pathways and Diseases |
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Pathway | CDC42 signaling events;PID Curated;200057 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Nephrin/Neph1 signaling in the kidney podocyte;PID Curated;200132 |
Pathway | Regulation of p38-alpha and p38-beta;PID Curated;200054 |
Pathway | Ephrin B reverse signaling;PID Curated;200173 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | ErbB1 downstream signaling;PID Curated;200113 |
Pathway | RhoA signaling pathway;PID Curated;200007 |
Pathway | pdgf signaling pathway;PID BioCarta;100077 |
Pathway | VEGFR3 signaling in lymphatic endothelium;PID Curated;200188 |
Pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met);PID Curated;200032 |
Pathway | FGF signaling pathway;PANTHER;P00021 |
Pathway | mapkinase signaling pathway;PID BioCarta;100113 |
Pathway | egf signaling pathway;PID BioCarta;100181 |
Pathway | TRAIL signaling pathway;PID Curated;200056 |
Pathway | EGF receptor signaling pathway;PANTHER;P00018 |
Pathway | CD40/CD40L signaling;PID Curated;200031 |
Pathway | Ras Pathway;PANTHER;P04393 |
Pathway | FAS signaling pathway;PANTHER;P00020 |
Pathway | tnfr1 signaling pathway;PID BioCarta;100015 |
Pathway | Signaling events mediated by focal adhesion kinase;PID Curated;200192 |
Pathway | inhibition of cellular proliferation by gleevec;PID BioCarta;100154 |
Pathway | map kinase inactivation of smrt corepressor;PID BioCarta;100032 |
Pathway | fc epsilon receptor i signaling in mast cells;PID BioCarta;100165 |
Pathway | fas signaling pathway (cd95);PID BioCarta;100167 |
Pathway | Regulation of Androgen receptor activity;PID Curated;200102 |
Pathway | ErbB signaling pathway;KEGG PATHWAY;hsa04012 |
Pathway | JNK signaling in the CD4+ TCR pathway;PID Curated;200129 |
Pathway | p38 mapk signaling pathway;PID BioCarta;100085 |
Pathway | keratinocyte differentiation;PID BioCarta;100119 |
Pathway | toll-like receptor pathway;PID BioCarta;100013 |
Pathway | Epithelial cell signaling in Helicobacter pylori infection;KEGG PATHWAY;hsa05120 |
Pathway | links between pyk2 and map kinases;PID BioCarta;100057 |
Pathway | Cellular roles of Anthrax toxin;PID Curated;200179 |
Pathway | angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling;PID BioCarta;100236 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | Integrin signalling pathway;PANTHER;P00034 |
Pathway | t cell receptor signaling pathway;PID BioCarta;100022 |
Pathway | Huntington disease;PANTHER;P00029 |
Pathway | GnRH signaling pathway;KEGG PATHWAY;hsa04912 |
Pathway | Chagas disease;KEGG PATHWAY;hsa05142 |
Pathway | Fc epsilon RI signaling pathway;KEGG PATHWAY;hsa04664 |
Pathway | Toll-like receptor signaling pathway;KEGG PATHWAY;hsa04620 |
Pathway | Fc-epsilon receptor I signaling in mast cells;PID Curated;200003 |
Pathway | Ceramide signaling pathway;PID Curated;200100 |
Pathway | tnf/stress related signaling;PID BioCarta;100026 |
Pathway | Oxidative stress response;PANTHER;P00046 |
Pathway | IL6-mediated signaling events;PID Curated;200124 |
Pathway | RAC1 signaling pathway;PID Curated;200190 |
Pathway | ceramide signaling pathway;PID BioCarta;100206 |
Disease | Sicca syndrome;FunDO |
Disease | Cancer;FunDO |
Disease | Rheumatoid arthritis;FunDO |
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External Links |
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Links to Entrez Gene | 6416 |
Links to all GeneRIF Items | 6416 |
Links to iHOP | 6416 |
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Sequence Information |
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Nucleotide Sequence |
>6416 : length: 1200 atggcggctccgagcccgagcggcggcggcggctccgggggcggcagcggcagcggcacc cccggccccgtagggtccccggcgccaggccacccggccgtcagcagcatgcagggtaaa cgcaaagcactgaagttgaattttgcaaatccacctttcaaatctacagcaaggtttact ctgaatcccaatcctacaggagttcaaaacccacacatagagagactgagaacacacagc attgagtcatcaggaaaactgaagatctcccctgaacaacactgggatttcactgcagag gacttgaaagaccttggagaaattggacgaggagcttatggttctgtcaacaaaatggtc cacaaaccaagtgggcaaataatggcagttaaaagaattcggtcaacagtggatgaaaaa gaacaaaaacaacttcttatggatttggatgtagtaatgcggagtagtgattgcccatac attgttcagttttatggtgcactcttcagagagggtgactgttggatctgtatggaactc atgtctacctcgtttgataagttttacaaatatgtatatagtgtattagatgatgttatt ccagaagaaattttaggcaaaatcactttagcaactgtgaaagcactaaaccacttaaaa gaaaacttgaaaattattcacagagatatcaaaccttccaatattcttctggacagaagt ggaaatattaagctctgtgacttcggcatcagtggacagcttgtggactctattgccaag acaagagatgctggctgtaggccatacatggcacctgaaagaatagacccaagcgcatca cgacaaggatatgatgtccgctctgatgtctggagtttggggatcacattgtatgagttg gccacaggccgatttccttatccaaagtggaatagtgtatttgatcaactaacacaagtc gtgaaaggagatcctccgcagctgagtaattctgaggaaagggaattctccccgagtttc atcaactttgtcaacttgtgccttacgaaggatgaatccaaaaggccaaagtataaagag cttctgaaacatccctttattttgatgtatgaagaacgtgccgttgaggtcgcatgctat gtttgtaaaatcctggatcaaatgccagctactcccagctctcccatgtatgtcgattga |
Protein Sequence |
>6416 : length: 399 MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGKRKALKLNFANPPFKSTARFT LNPNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMV HKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMEL MSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRS GNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYEL ATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKE LLKHPFILMYEERAVEVACYVCKILDQMPATPSSPMYVD |