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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 6477 |
Name | SIAH1 |
Synonym | SIAH1A;seven in absentia homolog 1 (Drosophila);SIAH1;seven in absentia homolog 1 (Drosophila) |
Definition | E3 ubiquitin-protein ligase SIAH1|siah-1a |
Position | 16q12 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 2 PubMed records as below. |
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Evidence Status |
Description |
potential | "SIAH1 has been identified as a putative tumor suppressor gene for human hepatocellular carcinomas, with a correlation between its suppressed expression and tumor size and differentiation." |
potential | Lack of somatic mutation in the coding sequence of SIAH1 in tumors hemizygous for this candidate tumor suppressor gene. |
| More detail of all 2 literatures about SIAH1 | |
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Pathways and Diseases |
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Pathway | Wnt signaling pathway;KEGG PATHWAY;hsa04310 |
Pathway | p53 pathway;PANTHER;P00059 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | Ubiquitin mediated proteolysis;KEGG PATHWAY;hsa04120 |
Pathway | Wnt signaling pathway;PANTHER;P00057 |
Pathway | Netrin-1 signaling;PID Reactome;500088 |
Pathway | p53 pathway feedback loops 2;PANTHER;P04398 |
Pathway | p53 signaling pathway;KEGG PATHWAY;hsa04115 |
Disease | Pancreas cancer;FunDO |
Disease | Liver cancer;FunDO |
Disease | Stomach cancer;FunDO |
Disease | Parkinson disease;FunDO |
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External Links |
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Links to Entrez Gene | 6477 |
Links to all GeneRIF Items | 6477 |
Links to iHOP | 6477 |
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Sequence Information |
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Nucleotide Sequence |
>6477 : length: 942 atgacgggaaaggctactccaccttctctgtactcctggaggggagtcttgttcacatgt ttaccagcggccaggacaaggaagagaaaagaaatgagccgtcagactgctacagcatta cctaccggtacctcgaagtgtccaccatcccagagggtgcctgccctgactggcacaact gcatccaacaatgacttggcgagtctttttgagtgtccagtctgctttgactatgtgtta ccgcccattcttcaatgtcagagtggccatcttgtttgtagcaactgtcgcccaaagctc acatgttgtccaacttgccggggccctttgggatccattcgcaacttggctatggagaaa gtggctaattcagtacttttcccctgtaaatatgcgtcttctggatgtgaaataactctg ccacacacagaaaaagcagaccatgaagagctctgtgagtttaggccttattcctgtccg tgccctggtgcttcctgtaaatggcaaggctctctggatgctgtaatgccccatctgatg catcagcataagtccattacaaccctacagggagaggatatagtttttcttgctacagac attaatcttcctggtgctgttgactgggtgatgatgcagtcctgttttggctttcacttc atgttagtcttagagaaacaggaaaaatacgatggtcaccagcagttcttcgcaatcgta cagctgataggaacacgcaagcaagctgaaaattttgcttaccgacttgagctaaatggt cataggcgacgattgacttgggaagcgactcctcgatctattcatgaaggaattgcaaca gccattatgaatagcgactgtctagtctttgacaccagcattgcacagctttttgcagaa aatggcaatttaggcatcaatgtaactatttccatgtgttga |
Protein Sequence |
>6477 : length: 313 MTGKATPPSLYSWRGVLFTCLPAARTRKRKEMSRQTATALPTGTSKCPPSQRVPALTGTT ASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNLAMEK VANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLM HQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIV QLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAE NGNLGINVTISMC |