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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 6711 |
Name | SPTBN1 |
Synonym | ELF|SPTB2|betaSpII;spectrin, beta, non-erythrocytic 1;SPTBN1;spectrin, beta, non-erythrocytic 1 |
Definition | beta-G spectrin|beta-II spectrin|beta-fodrin|beta-spectrin 2|beta-spectrin II|embryonic liver beta-fodrin|fodrin beta chain|spectrin beta chain, brain 1|spectrin, non-erythroid beta chain 1 |
Position | 2p21 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 2 PubMed records as below. |
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Evidence Status |
Description |
potential | "reduced SPTBN1 expression correlated with shorter survival of pancreatic cancer patients, suggesting a tumor suppressor function of this gene". |
potential | RING finger-dependent ubiquitination by PRAJA is dependent on TGF-beta and potentially defines the functional status of the tumor suppressor ELF. |
| More detail of all 2 literatures about SPTBN1 | |
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Pathways and Diseases |
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Pathway | Interactions of the immunoglobulin superfamily (IgSF) member proteins;Reactome;REACT:23853 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | TGF-beta receptor signaling;PID Curated;200195 |
Disease | Bone mineral density (spine);GAD |
Disease | METABOLIC;GAD |
Disease | Bone mineral density (spine);NHGRI |
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External Links |
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Links to Entrez Gene | 6711 |
Links to all GeneRIF Items | 6711 |
Links to iHOP | 6711 |
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Sequence Information |
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Nucleotide Sequence |
>6711 : length: 7095 atgacgaccacagtagccacagactatgacaacattgagatccagcagcagtacagtgat gtcaacaaccgctgggatgtcgacgactgggacaatgagaacagctctgcgcggcttttt gagcggtcccgcatcaaggctctggcagatgagcgtgaagccgtgcagaagaagaccttc accaagtgggtcaattcccaccttgcccgtgtgtcctgccggatcacagacctgtacact gaccttcgagatggacggatgctcatcaagctgctggaggtcctctctggagagaggctg cctaaacccaccaagggacgaatgcgcatccactgcttagagaatgtggacaaggccctt cagttcctgaaggagcagagagtccatcttgagaacatggggtcccatgacatcgtggat ggaaaccaccggctgacccttggcctcatctggaccatcatcctgcgcttccagatccag gatatcagtgtggaaactgaagacaacaaagagaagaaatctgccaaggatgcattgctg ttgtggtgccagatgaagacagctgggtaccccaatgtcaacattcacaatttcaccact agctggagggacggcatggccttcaatgcactgatacacaaacaccggcctgacctgata gattttgacaaactaaagaaatctaacgcacactacaacctgcagaatgcatttaatctg gcagaacagcacctcggcctcactaaactgttggaccccgaagacatcagcgtggaccat cctgatgagaagtccataatcacttatgtggtgacttattaccactacttctctaagatg aaggccttagctgttgaaggaaaacgaattggaaaggtgcttgacaatgctattgaaaca gaaaaaatgattgaaaagtatgaatcacttgcctctgaccttctggaatggattgaacaa accatcatcattctgaacaatcgcaaatttgccaattcactggtcggggttcaacagcag cttcaggcattcaacacttaccgcactgtggagaaaccacccaaatttactgagaagggg aacttggaagtgctgctcttcaccattcagagcaagatgagggccaacaaccagaaggtc tacatgccccgggaggggaagctcatctctgacatcaacaaggcctgggaaagactggaa aaagcggaacacgaaagagaactggctttgcggaatgagctcataagacaggagaaactg gaacagctcgcccgcagatttgatcgcaaggcagctatgagggagacttggctgagcgaa aaccagcgtctggtgtctcaggacaactttgggtttgaccttcctgcagttgaggccgcc acaaaaaagcacgaggccattgagacagacattgccgcatacgaggagcgtgtgcaggct gtggtagccgtggccagggagctcgaggccgagaattaccacgacatcaagcgcatcaca gcgaggaaggacaatgtcatccggctctgggaatacctactggaactgctcagggcccgg agacagcggctcgagatgaacctggggctgcagaagatattccaggaaatgctctacatt atggactggatggatgaaatgaaggtgctagtattgtctcaagactatggcaaacactta cttggtgtggaagacctgttacagaagcacaccctggttgaagcagacattggcatccag gcagagcgggtgagaggtgtcaatgcctccgcccagaagttcgcaacagacggggaaggt tacaagccctgtgacccccaggtgatccgagaccgcgtggcccacatggagttctgttat caagagctttgccagctggcggctgagcgcagggcccgtctggaagagtcccgccgcctc tggaagttcttctgggagatggcagaagaggaaggctggatacgggagaaggagaagatc ctgtcctcggacgattacgggaaagacctgaccagcgtcatgcgcctgctcagcaagcac cgggcgttcgaggacgagatgagcggccgcagtggccactttgagcaggccatcaaggaa ggcgaagacatgatcgcggaggagcacttcgggtcggagaagatccgtgagaggatcatt tacatccgggagcagtgggccaacctagagcagctctcggccattcggaagaagcgcctg gaggaggcctccctgctgcaccagttccaggcagatgctgatgacattgatgcctggatg ctggacatcctcaagattgtctccagcagcgacgtgggccacgatgagtattccacacag tctctggtcaagaaacacaaggacgtggcggaagagatcgccaattacaggcccaccctt gacacgctgcacgaacaagccagcgccctcccccaggagcatgccgagtctccagacgtg aggggcaggctgtcgggcatcgaggagcggtataaggaggtggcagagctgacgcggctg cggaagcaggcactccaggacactctggccctgtacaagatgttcagcgaggctgatgcc tgtgagctctggatcgacgagaaggagcagtggctcaacaacatgcagatcccagagaag ctggaggatctggaggtcatccagcacagatttgagagcctagaaccagaaatgaacaac caggcttcccgggttgcagtggtgaaccagattgcacgccagctgatgcacagcggccac ccaagtgagaaggaaatcaaagcccagcaggacaaactcaacacaaggtggagccagttc agagaactggttgacaggaagaaggatgccctcctgtctgccctgagcatccagaactac cacctcgagtgcaatgaaaccaaatcctggattcgggaaaagaccaaggtcatcgagtcc acccaggacctgggcaatgacctggctggcgtcatggccctgcagcgcaagctgaccggc atggagcgggacttggtggccattgaggcaaagctgagtgacctgcagaaggaggcggag aagctggagtccgagcaccccgaccaggcccaggccatcctgtctcggctggccgagatc agcgacgtgtgggaggagatgaagaccaccctgaaaaaccgagaggcctccctgggagag gccagcaagctgcagcagttcctacgggacttggacgacttccagtcctggctctctagg acccagacagcgatcgcctcggaggacatgccaaacaccctgaccgaggctgagaagctg ctcacgcagcacgagaacatcaagaacgagatcgacaactacgaggaggactaccagaag atgagggacatgggcgagatggtcacccaggggcagaccgatgcccagtacatgtttctg cggcagcggctgcaggccctggacactggatggaacgagctccacaagatgtgggagaac agacaaaatctcctatcccagtcacatgcctaccagcagttcctcagagacacgaagcaa gccgaagcctttcttaacaaccaggagtatgttctggctcacactgaaatgcctaccacc ttggaaggagctgaagcagcaattaaaaagcaagaggacttcatgaccaccatggacgcc aatgaggagaagatcaatgctgtggtggagactggccggaggctggtgagcgatgggaac atcaactcagatcgcatccaggagaaggtggactctattgatgacagacataggaagaat cgtgagacagccagtgaacttttgatgaggttgaaggacaacagggatctacagaaattc ctgcaagattgtcaagagctgtctctctggatcaatgagaagatgctcacagcccaggac atgtcttacgatgaagccagaaatctgcacagtaaatggttgaagcatcaagcatttatg gcagaacttgcatccaacaaagaatggcttgacaaaatcgagaaggaaggaatgcagctc atttcagaaaagcctgagacggaagctgtggtgaaggagaaactcactggtttacataaa atgtgggaagtccttgaatccactacccagacaaaggcccagcggctctttgatgcaaac aaggccgaacttttcacccagagctgtgcagatctagacaaatggctgcacggcctggag agtcagattcagtctgatgactatggcaaagacctgaccagtgtcaatatcctgctgaaa aagcaacagatgctggagaatcagatggaagtgcggaagaaggagatcgaagagctccaa agccaagcccaggccctgagtcaggaagggaagagcaccgacgaggtagacagcaagcgc ctcaccgtgcagaccaagttcatggagttgctggagcccttgaacgagaggaagcataac ctgctggcctccaaagagatccatcagttcaacagggatgtggaggacgagatcttgtgg gttggagagaggatgcctttggcaacttccacggatcatggccacaacctccagactgtg cagctgttaataaagaaaaatcagaccctccagaaagaaatccaggggcaccagcctcgc attgacgacatctttgagaggagccaaaacatcgtcactgacagcagcagcctcagcgct gaggccatcagacagaggcttgccgacctgaagcagctgtggggtctcctcattgaggag acagagaaacgccacaggcggctggaggaggcgcacagggcccagcagtactactttgac gctgctgaggccgaagcctggatgagcgagcaggagctgtacatgatgtcagaggagaag gccaaggatgagcagagtgctgtctccatgttgaagaagcaccagatcttagaacaagct gtggaggactatgcagagaccgtgcatcagctctccaagaccagccgggccctggtggcc gacagccatcctgaaagtgagcgcattagcatgcggcagtccaaagtggataaactgtac gctggtctgaaagaccttgctgaagagagaagaggcaagctggatgagagacacaggtta ttccagctcaaccgggaggtggacgacctggagcagtggatcgctgagagggaggtggtc gcagggtcccatgaactgggacaggactatgagcatgtcacgatgttacaagaacgattc cgggagtttgcccgagacaccgggaacattgggcaggagcgcgtggacacggtcaatcac ctggcagatgagctcatcaactctggacattcagatgccgccaccatcgctgaatggaag gatggcctcaatgaagcctgggccgacctcctggagctcattgacacaagaacacagatt cttgccgcttcctatgaactgcacaagttttaccacgatgccaaggagatctttgggcgt atacaggacaaacacaagaaactccctgaggagcttgggagagatcagaacacagtggag accttacagagaatgcacactacatttgagcatgacatccaggctctgggcacacaggtg aggcagctgcaggaggatgcagcccgcctccaggcggcctatgcgggtgacaaggccgac gatatccagaagcgcgagaacgaggtcctggaagcctggaagtccctcctggacgcctgt gagagccgcagggtgcggctggtggacacaggggacaagttccgcttcttcagcatggtg cgcgacctcatgctctggatggaggatgtcatccggcagatcgaggcccaggagaagcca agggatgtatcatctgttgaactcttaatgaataatcatcaaggcatcaaagctgaaatt gatgcacgtaatgacagtttcacaacctgcattgaacttgggaaatccctgttggcgaga aaacactatgcatctgaggagatcaaggaaaaattactgcagttgacggaaaagaggaaa gaaatgatcgacaagtgggaagaccgatgggaatggttaagactgattctggaggtccat cagttctcaagagacgccagtgtggccgaggcctggctgcttggacaggagccgtaccta tccagccgagagataggccagagcgtggacgaggtggagaagctcatcaagcgccacgag gcatttgaaaagtctgcagcaacctgggatgagaggttctctgccctggaaaggctgact acattggagttactggaagtgcgcagacagcaagaggaagaggagaggaagaggcggccg ccttctcccgagccgagcacgaaggtttcagaggaagccgagtcccagcagcagtgggat acttcaaaaggagaacaagtttcccaaaacggtttgccagctgaacagggatctccacgg atggcagaaacggtggacacaagcgaaatggtcaacggcgctacagaacaaaggacgagc tctaaagagtccagccccatcccctccccgacctctgatcgtaaagccaagactgccctc ccagcccagagtgccgccaccttaccagccagaacccaggagacaccttcggcccagatg gaaggcttcctcaatcggaaacacgagtgggaggcccacaataagaaagcctcaagcagg tcctggcacaatgtttattgtgtcataaataaccaagaaatgggtttctacaaagatgca aagactgctgcttctggaattccctaccacagcgaggtccctgtgagtttgaaagaagct gtctgcgaagtggcccttgattacaaaaagaagaaacacgtattcaagctaagactaaat gatggcaatgagtacctcttccaagccaaagacgatgaggaaatgaacacatggatccag gctatctcttccgccatctcctctgataaacacgaggtgtctgccagcacccagagcacg ccagcatccagccgcgcgcagaccctccccaccagcgtcgtcaccatcaccagcgagtcc agtcccggcaagcgggaaaaggacaaagagaaagacaaagagaagcggttcagccttttt ggcaaaaagaaatga |
Protein Sequence |
>6711 : length: 2364 MTTTVATDYDNIEIQQQYSDVNNRWDVDDWDNENSSARLFERSRIKALADEREAVQKKTF TKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENVDKAL QFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDALL LWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNL AEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIET EKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKG NLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKL EQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQA VVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYI MDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEG YKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKI LSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERII YIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQ SLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRL RKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNN QASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNY HLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAE KLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSR TQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFL RQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTT LEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKN RETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFM AELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDAN KAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQ SQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILW VGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSA EAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEK AKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLY AGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERF REFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQI LAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQV RQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMV RDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLAR KHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYL SSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRP PSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTS SKESSPIPSPTSDRKAKTALPAQSAATLPARTQETPSAQMEGFLNRKHEWEAHNKKASSR SWHNVYCVINNQEMGFYKDAKTAASGIPYHSEVPVSLKEAVCEVALDYKKKKHVFKLRLN DGNEYLFQAKDDEEMNTWIQAISSAISSDKHEVSASTQSTPASSRAQTLPTSVVTITSES SPGKREKDKEKDKEKRFSLFGKKK |