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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 7020 |
Name | TFAP2A |
Synonym | AP-2|AP-2alpha|AP2TF|BOFS|TFAP2;transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha);TFAP2A;transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
Definition | AP-2 transcription factor|AP2-alpha|activating enhancer-binding protein 2-alpha|activator protein 2|transcription factor AP-2-alpha |
Position | 6p24 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 4 PubMed records as below. |
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Evidence Status |
Description |
reviewed | Protein-binding microarray analysis of tumor suppressor AP2α target gene specificity. |
reviewed | these studies support a tumor suppressor role for AP-2alpha in the gastrointestinal tract. |
potential | data provide evidence that AP-2alpha acts as a tumor suppressor gene in colon cancer. |
reviewed | Results indicate that the tumor suppressor activity of AP2alpha is mediated through a direct interaction with p53. |
reviewed | these studies support a tumor suppressor role for AP-2alpha in the gastrointestinal tract. |
| More detail of all 4 literatures about TFAP2A | |
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Pathways and Diseases |
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Pathway | Caspase cascade in apoptosis;PID Curated;200148 |
Disease | Branchiooculofacial syndrome;OMIM |
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External Links |
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Links to Entrez Gene | 7020 |
Links to all GeneRIF Items | 7020 |
Links to iHOP | 7020 |
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Sequence Information |
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Nucleotide Sequence |
>7020 : length: 1296 atgttagttcacagtttttcagccatggaccgtcacgacggcaccagcaacgggacggca cggttgccccagctgggcactgtaggtcaatctccctacacgagcgccccgccgctgtcc cacacccccaatgccgacttccagcccccatacttccccccaccctaccagcctatctac ccccagtcgcaagatccttactcccacgtcaacgacccctacagcctgaaccccctgcac gcccagccgcagccgcagcacccaggctggcccggccagaggcagagccaggagtctggg ctcctgcacacgcaccgggggctgcctcaccagctgtcgggcctggatcctcgcagggac tacaggcggcacgaggacctcctgcacggcccacacgcgctcagctcaggactcggagac ctctcgatccactccttacctcacgccatcgaggaggtcccgcatgtagaagacccgggt attaacatcccagatcaaactgtaattaagaaaggccccgtgtccctgtccaagtccaac agcaatgccgtctccgccatccctattaacaaggacaacctcttcggcggcgtggtgaac cccaacgaagtcttctgttcagttccgggtcgcctctcgctcctcagctccacctcgaag tacaaggtcacggtggcggaagtgcagcggcggctctcaccacccgagtgtctcaacgcg tcgctgctgggcggagtgctccggagggcgaagtctaaaaatggaggaagatctttaaga gaaaaactggacaaaataggattaaatctgcctgcagggagacgtaaagctgccaacgtt accctgctcacatcactagtagagggagaagctgtccacctagccagggactttgggtac gtgtgcgaaaccgaatttcctgccaaagcagtagctgaatttctcaaccgacaacattcc gatcccaatgagcaagtgacaagaaaaaacatgctcctggctacaaaacagatatgcaaa gagttcaccgacctgctggctcaggaccgatctcccctggggaactcacggcccaacccc atcctggagcccggcatccagagctgcttgacccacttcaacctcatctcccacggcttc ggcagccccgcggtgtgtgccgcggtcacggccctgcagaactatctcaccgaggccctc aaggccatggacaaaatgtacctcagcaacaaccccaacagccacacggacaacaacgcc aaaagcagtgacaaagaggagaagcacagaaagtga |
Protein Sequence |
>7020 : length: 431 MLVHSFSAMDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHTPNADFQPPYFPPPYQPIY PQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSGLDPRRD YRRHEDLLHGPHALSSGLGDLSIHSLPHAIEEVPHVEDPGINIPDQTVIKKGPVSLSKSN SNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNA SLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGY VCETEFPAKAVAEFLNRQHSDPNEQVTRKNMLLATKQICKEFTDLLAQDRSPLGNSRPNP ILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNPNSHTDNNA KSSDKEEKHRK |