Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

7020

Name

TFAP2A

Synonym

AP-2|AP-2alpha|AP2TF|BOFS|TFAP2;transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha);TFAP2A;transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)

Definition

AP-2 transcription factor|AP2-alpha|activating enhancer-binding protein 2-alpha|activator protein 2|transcription factor AP-2-alpha

Position

6p24

Gene Type

protein-coding

Source

Count: 2; Pubmed_search,Generif

Literature support

Count: 4 PubMed records as below.

Evidence Status

Description

reviewed

Protein-binding microarray analysis of tumor suppressor AP2α target gene specificity.

reviewed

these studies support a tumor suppressor role for AP-2alpha in the gastrointestinal tract.

potential

data provide evidence that AP-2alpha acts as a tumor suppressor gene in colon cancer.

reviewed

Results indicate that the tumor suppressor activity of AP2alpha is mediated through a direct interaction with p53.

reviewed

these studies support a tumor suppressor role for AP-2alpha in the gastrointestinal tract.
More detail of all 4 literatures about TFAP2A

Pathways and Diseases

Pathway

Caspase cascade in apoptosis;PID Curated;200148

Disease

Branchiooculofacial syndrome;OMIM

External Links

Links to Entrez Gene

7020

Links to all GeneRIF Items

7020

Links to iHOP

7020

Sequence Information

Nucleotide Sequence

>7020 : length: 1296
atgttagttcacagtttttcagccatggaccgtcacgacggcaccagcaacgggacggca
cggttgccccagctgggcactgtaggtcaatctccctacacgagcgccccgccgctgtcc
cacacccccaatgccgacttccagcccccatacttccccccaccctaccagcctatctac
ccccagtcgcaagatccttactcccacgtcaacgacccctacagcctgaaccccctgcac
gcccagccgcagccgcagcacccaggctggcccggccagaggcagagccaggagtctggg
ctcctgcacacgcaccgggggctgcctcaccagctgtcgggcctggatcctcgcagggac
tacaggcggcacgaggacctcctgcacggcccacacgcgctcagctcaggactcggagac
ctctcgatccactccttacctcacgccatcgaggaggtcccgcatgtagaagacccgggt
attaacatcccagatcaaactgtaattaagaaaggccccgtgtccctgtccaagtccaac
agcaatgccgtctccgccatccctattaacaaggacaacctcttcggcggcgtggtgaac
cccaacgaagtcttctgttcagttccgggtcgcctctcgctcctcagctccacctcgaag
tacaaggtcacggtggcggaagtgcagcggcggctctcaccacccgagtgtctcaacgcg
tcgctgctgggcggagtgctccggagggcgaagtctaaaaatggaggaagatctttaaga
gaaaaactggacaaaataggattaaatctgcctgcagggagacgtaaagctgccaacgtt
accctgctcacatcactagtagagggagaagctgtccacctagccagggactttgggtac
gtgtgcgaaaccgaatttcctgccaaagcagtagctgaatttctcaaccgacaacattcc
gatcccaatgagcaagtgacaagaaaaaacatgctcctggctacaaaacagatatgcaaa
gagttcaccgacctgctggctcaggaccgatctcccctggggaactcacggcccaacccc
atcctggagcccggcatccagagctgcttgacccacttcaacctcatctcccacggcttc
ggcagccccgcggtgtgtgccgcggtcacggccctgcagaactatctcaccgaggccctc
aaggccatggacaaaatgtacctcagcaacaaccccaacagccacacggacaacaacgcc
aaaagcagtgacaaagaggagaagcacagaaagtga

Protein Sequence

>7020 : length: 431
MLVHSFSAMDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHTPNADFQPPYFPPPYQPIY
PQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSGLDPRRD
YRRHEDLLHGPHALSSGLGDLSIHSLPHAIEEVPHVEDPGINIPDQTVIKKGPVSLSKSN
SNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNA
SLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGY
VCETEFPAKAVAEFLNRQHSDPNEQVTRKNMLLATKQICKEFTDLLAQDRSPLGNSRPNP
ILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNPNSHTDNNA
KSSDKEEKHRK



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