Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

7020

Name

TFAP2A

Synonymous

AP-2|AP-2alpha|AP2TF|BOFS|TFAP2;transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha);TFAP2A;transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)

Definition

AP-2 transcription factor|AP2-alpha|activating enhancer-binding protein 2-alpha|activator protein 2|transcription factor AP-2-alpha

Position

6p24

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors

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Regulation From TransFac database

AP-2alpha(h) --Caspase-6(h)--> protein remnants (processing)
AP-2alpha(h) + ATP --PKAc(h)--> AP-2alpha(h){pS239} + ADP (phosphorylation)
AP-2alpha(h) + sumo1(h) --> AP-2alpha(h){sumo} (sumoylation)
AP-2alpha(h) + Ubc9(h) <==> AP-2alpha(h):Ubc9(h) (binding)
AP-2alpha(h) + Sp1(h) <==> AP-2alpha(h):Sp1(h) (binding)
2 AP-2alpha(h) <==> AP-2alpha(h):AP-2alpha(h) (binding) [f
AP-2alpha(h) + MRG-1-isoform2(h) + p300(h) <==> AP-2alpha(h):MRG-1-isoform2(h):p300(h) (binding)
AP-2alpha(h) + MRG-1-isoform2(h) <==> AP-2alpha(h):MRG-1-isoform2(h) (binding)
AP-2alpha(h) + p300(h) <==> AP-2alpha(h):p300(h) (binding)
AP-2alpha(h) + CITED4(h) <==> AP-2alpha(h):CITED4(h) (binding)
AP-2alpha(h) --> FGFR4(h) (DNA binding; transactivation).
AP-2alpha(h) --/ SOD2(h) (DNA binding; transrepression).
MAGI-1(h) + AP-2alpha(h) <==> MAGI-1(h):AP-2alpha(h) (binding)
AIP5(h) + AP-2alpha(h) <==> AIP5(h):AP-2alpha(h) (binding)
p53-isoform1(h) + AP-2alpha(h) <==> p53-isoform1(h):AP-2alpha(h) (binding)
p53(m.s.) + AP-2alpha(h) <==> p53(m.s.):AP-2alpha(h) (binding)
p53(h) + AP-2alpha(h) <==> p53(h):AP-2alpha(h) (binding)
pax6(h) + AP-2alpha(h) <==> pax6(h):AP-2alpha(h) (binding)
AP-2alpha(h) --> KRT14(h) (DNA binding).
AP-2alpha(h) --> DRD1A(h) (DNA binding).
AP-2alpha(h) --> TFAP2A(h) (DNA binding).
AP-2alpha(h) --> TAF7(h) (DNA binding; transactivation).
AP-2alpha(h) --> TALDO1(h) (DNA binding).
AP-2alpha(h) --> Sod2(r) (DNA binding).
AP-2alpha(h) --> CD82(h) (DNA binding).
AP-2alpha(h) --> HTT(h) (DNA binding).
AP-2alpha(h) --> HGF(m) (DNA binding).
AP-2alpha(h) --> VHL(h) (DNA binding).
AP-2alpha(h) --> FMR1(h) (DNA binding).
AP-2alpha(h) --> FXR2(h) (DNA binding).
AP-2alpha(h) --> Npt2(r) (DNA binding).
AP-2alpha(h) --> ACACA(r) (DNA binding).
AP-2alpha(h) --> MAPT(r) (DNA binding).
AP-2alpha(h) --> CYP11A1(h) (DNA binding).
AP-2alpha(h) --> Cyp11a1(r) (DNA binding).
AP-2alpha(h) + HMGIY(h) <==> AP-2alpha(h):HMGIY(h) (binding)
AP-2alpha(h) + Sp1(m.s.) <==> AP-2alpha(h):Sp1(m.s.) (binding)
AP-2alpha(h) --> APP(h) (DNA binding).
AP-2alpha(h) --> MT2A(h) (DNA binding).
AP-2alpha(h) --> ERBB2(h) (DNA binding).
AP-2alpha(h) --> IGF1R(h) (DNA binding).
AP-2alpha(h) --> MUC5B(h) (DNA binding).
AP-2alpha(h) --> CSH1(h) (DNA binding).
AP-2alpha(h) --> ULBP1(h) (DNA binding).
AP-2alpha(h) + CD229(h) <==> AP-2alpha(h):CD229(h) (binding)
AP-2alpha(h) --> BRS3(h) (DNA binding).
AP-2alpha(h) --> EGFR(h) (DNA binding).
AP-2alpha(h) --> RAD51(h) (DNA binding).
AP-2alpha(h) --> IVL(h) (DNA binding).
AP-2alpha(h) --> KRT1(h) (DNA binding).
AP-2alpha(h) --> CSPG2(h) (DNA binding; transactivation).
AP-2alpha(h) --> TGM1(h) (DNA binding).
AP-2alpha(h) + DEK(r) <==> AP-2alpha(h):DEK(r) (binding)
AP-2alpha(h) --> apoE(h) (DNA binding).
AP-2alpha(h) --> MMP2(h) (DNA binding).
AP-2alpha(h) --> IRF-6(h) (DNA binding).
AP-2alpha(h) --> CGB5(h) (DNA binding).
TFAP2A(h) --> AP-2alpha(h) (expression).
TFAP2A(h) --> AP-2alphaB(h) (expression).
AP-2alphaA(h) --> GH1(h) (DNA binding; transregulation).
AP-2alphaA(h) --> MT2A(h) (DNA binding; transregulation).
AP-2alphaA(h) --> H-2Kb(m) (DNA binding; transregulation).
AP-2alphaA(h) --> ENK(h) (DNA binding; transregulation).
AP-2alphaA(h) --> GFAP(h) (DNA binding).
AP-2alphaA(h) --> CEACAM1(h) (DNA binding).
AP-2alphaA(h) --> Mmp2(r) (DNA binding; transregulation).
AP-2alphaA(h) --> AChR alpha(r) (DNA binding).
AP-2alphaA(h) --> BPV-1(BPV1) (DNA binding; transregulation).
AP-2alphaA(h) --> HTLV-I(HT1) (DNA binding).
AP-2alphaA(h) --> JUN(h) (DNA binding; transregulation).
AP-2alphaA(h) --> MMTV(MMTV) (DNA binding; transregulation).
AP-2alphaA(h) --> SV40(sv) (DNA binding; transregulation).
AP-2alphaA(h) --> apoB(h) (DNA binding).
AP-2alphaA(h) --> Ptma(r) (DNA binding; transregulation).
AP-2alphaA(h) --> ODC1(h) (DNA binding).
AP-2alphaA(h) --> ADM(h) (DNA binding).
AP-2alphaA(h) --> KRT14(h) (DNA binding).
AP-2alphaA(h) --> TCR-alpha(h) (DNA binding).
AP-2alphaA(h) --> ATF2(h) (DNA binding).
AP-2alphaA(h) --> MIP(h) (DNA binding).
AP-2alphaA(h) --> c-myc(h) (DNA binding; transregulation).
AP-2alphaA(h) --> IFNG(h) (DNA binding).
AP-2alphaA(h) --> MMP2(h) (DNA binding).
AP-2alphaA(h) --> CCNB1(h) (DNA binding).
AP-2alphaA(h) + c-Myc(h) <==> AP-2alphaA(h):c-Myc(h) (binding).
AP-2alphaA(h) + YB-1(h) <==> AP-2alphaA(h):YB-1(h) (binding).
AP-2alphaA(h) + E1A 12S protein(AD) <==> AP-2alphaA(h):E1A 12S protein(AD) (binding).
AP-2alphaA(h) --> HSPB1(h) (DNA binding; transactivation).
AP-2alphaA(h) + AP-2alphaA(h) <==> AP-2alphaA(h):AP-2alphaA(h) (binding).
AP-2alphaA(h) --/ HSD17B1(h) (DNA binding; transrepression).
AP-2alphaA(h) --> REL(h) (DNA binding)
AP-2alphaA(h) --/ C3(h) (DNA binding; transrepression).
AP-2alphaA(h) --/ SAA1(r) (DNA binding; transrepression).
AP-2alphaA(h) --> KRT3(rb) (DNA binding; transactivation).
AP-2alphaA(h) --> KIT(h) (DNA binding; transactivation).
AP-2alphaA(h) --> CGB(h) (DNA binding; transactivation).
AP-2alphaA(h) --> PRKCA(h) (DNA binding).
AP-2alphaA(h) --> CGA(h) (DNA binding; transactivation).
AP-2alphaA(h) --> CEBPA(h) (DNA binding).
AP-2alphaA(h) --> KRT1(h) (DNA binding).
AP-2alphaA(h) --> KRT6B(h) (DNA binding).
AP-2alphaA(h) + Sp1(m.s.) <==> AP-2alphaA(h):Sp1(m.s.) (binding)
TFAP2A(h) --> AP-2alphaA(h) (expression).

Post Transcriptional Modification From dbPTM

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Location (AA)

PTM type

Literature

Database

239Phosphoserine (by PKA).Swiss-Prot 53.0
10Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO)(Probable).Swiss-Prot 53.0

Methylation Profile From DiseaseMeth database

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Chromosome

Location

Source

chr6

 Promoter: 10520093 - 10522093Agilent_014791

chr6

 Promoter: 10522956 - 10524956Agilent_014791

chr6

 Promoter: 10520093 - 10522093GSE27584

chr6

 Promoter: 10527283 - 10529283GSE27584

chr6

 Promoter: 10522956 - 10524956GSE27584

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