Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

7048

Name

TGFBR2

Synonym

AAT3|FAA3|LDS1B|LDS2B|MFS2|RIIC|TAAD2|TGFR-2|TGFbeta-RII;transforming growth factor, beta receptor II (70/80kDa);TGFBR2;transforming growth factor, beta receptor II (70/80kDa)

Definition

TGF-beta receptor type II|TGF-beta receptor type IIB|TGF-beta receptor type-2|TGF-beta type II receptor|tbetaR-II|transforming growth factor beta receptor type IIC|transforming growth factor, beta receptor II (70/80kDa) isoform 1|transforming growth facto

Position

3p22

Gene Type

protein-coding

Source

Count: 2; TAG,Generif

Literature support

Count: 3 PubMed records as below.

Evidence Status

Description

reviewed

Transforming growth factor beta receptor 2 (TGFBR2) is a tumor suppressor gene that plays a role in the differentiation of striated cells and remodeling of coronary arteries.

reviewed

TGF-? acts as a suppressor of primary tumor initiation but has been implicated as a promoter of the later malignant stages.

reviewed

TGFBR2 gene is a tumor suppressor gene located at chromosome 3p22.
More detail of all 3 literatures about TGFBR2

Pathways and Diseases

Pathway

Chagas disease;KEGG PATHWAY;hsa05142

Pathway

Endocytosis;KEGG PATHWAY;hsa04144

Pathway

ctcf: first multivalent nuclear factor;PID BioCarta;100194

Pathway

Integrins in angiogenesis;PID Curated;200109

Pathway

Adherens junction;KEGG PATHWAY;hsa04520

Pathway

Chronic myeloid leukemia;KEGG PATHWAY;hsa05220

Pathway

Cytokine-cytokine receptor interaction;KEGG PATHWAY;hsa04060

Pathway

TGF-beta receptor signaling;PID Curated;200195

Pathway

MAPK signaling pathway;KEGG PATHWAY;hsa04010

Pathway

ALK1 signaling events;PID Curated;200126

Pathway

nfkb activation by nontypeable hemophilus influenzae;PID BioCarta;100088

Pathway

TGF-beta signaling pathway;PANTHER;P00052

Pathway

tgf beta signaling pathway;PID BioCarta;100017

Pathway

TGF-beta signaling pathway;KEGG PATHWAY;hsa04350

Pathway

Glypican 1 network;PID Curated;200021

Pathway

Signaling by TGF beta;Reactome;REACT:6844

Pathway

Pathways in cancer;KEGG PATHWAY;hsa05200

Pathway

alk in cardiac myocytes;PID BioCarta;100244

Pathway

Colorectal cancer;KEGG PATHWAY;hsa05210

Pathway

Pancreatic cancer;KEGG PATHWAY;hsa05212

Disease

Colorectal cancer;KEGG DISEASE;H00020

Disease

tonometry;GAD

Disease

Cancers;KEGG DISEASE

Disease

Loeys-Dietz syndrome, type 1B;OMIM

Disease

Loeys-Dietz syndrome, type 2B;OMIM

Disease

gastric cancer;GAD

Disease

CARDIOVASCULAR;GAD

Disease

Tonometry;NHGRI

Disease

CANCER;GAD

Disease

Esophageal cancer, somatic;OMIM

Disease

Cancers of the digestive system;KEGG DISEASE

Disease

Colorectal cancer, hereditary nonpolyposis, type 6;OMIM

Disease

Aortic Aneurysm, Abdominal;GAD

Disease

stomach cancer;GAD

Disease

colorectal cancer;GAD

External Links

Links to Entrez Gene

7048

Links to all GeneRIF Items

7048

Links to iHOP

7048

Sequence Information

Nucleotide Sequence

>7048 : length: 1779
atgggtcgggggctgctcaggggcctgtggccgctgcacatcgtcctgtggacgcgtatc
gccagcacgatcccaccgcacgttcagaagtcggatgtggaaatggaggcccagaaagat
gaaatcatctgccccagctgtaataggactgcccatccactgagacatattaataacgac
atgatagtcactgacaacaacggtgcagtcaagtttccacaactgtgtaaattttgtgat
gtgagattttccacctgtgacaaccagaaatcctgcatgagcaactgcagcatcacctcc
atctgtgagaagccacaggaagtctgtgtggctgtatggagaaagaatgacgagaacata
acactagagacagtttgccatgaccccaagctcccctaccatgactttattctggaagat
gctgcttctccaaagtgcattatgaaggaaaaaaaaaagcctggtgagactttcttcatg
tgttcctgtagctctgatgagtgcaatgacaacatcatcttctcagaagaatataacacc
agcaatcctgacttgttgctagtcatatttcaagtgacaggcatcagcctcctgccacca
ctgggagttgccatatctgtcatcatcatcttctactgctaccgcgttaaccggcagcag
aagctgagttcaacctgggaaaccggcaagacgcggaagctcatggagttcagcgagcac
tgtgccatcatcctggaagatgaccgctctgacatcagctccacgtgtgccaacaacatc
aaccacaacacagagctgctgcccattgagctggacaccctggtggggaaaggtcgcttt
gctgaggtctataaggccaagctgaagcagaacacttcagagcagtttgagacagtggca
gtcaagatctttccctatgaggagtatgcctcttggaagacagagaaggacatcttctca
gacatcaatctgaagcatgagaacatactccagttcctgacggctgaggagcggaagacg
gagttggggaaacaatactggctgatcaccgccttccacgccaagggcaacctacaggag
tacctgacgcggcatgtcatcagctgggaggacctgcgcaagctgggcagctccctcgcc
cgggggattgctcacctccacagtgatcacactccatgtgggaggcccaagatgcccatc
gtgcacagggacctcaagagctccaatatcctcgtgaagaacgacctaacctgctgcctg
tgtgactttgggctttccctgcgtctggaccctactctgtctgtggatgacctggctaac
agtgggcaggtgggaactgcaagatacatggctccagaagtcctagaatccaggatgaat
ttggagaatgttgagtccttcaagcagaccgatgtctactccatggctctggtgctctgg
gaaatgacatctcgctgtaatgcagtgggagaagtaaaagattatgagcctccatttggt
tccaaggtgcgggagcacccctgtgtcgaaagcatgaaggacaacgtgttgagagatcga
gggcgaccagaaattcccagcttctggctcaaccaccagggcatccagatggtgtgtgag
acgttgactgagtgctgggaccacgacccagaggcccgtctcacagcccagtgtgtggca
gaacgcttcagtgagctggagcatctggacaggctctcggggaggagctgctcggaggag
aagattcctgaagacggctccctaaacactaccaaatag

Protein Sequence

>7048 : length: 592
MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSDVEMEAQKDEIICPSCNRTAHPLRHINND
MIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENI
TLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNT
SNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEH
CAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVA
VKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQE
YLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCL
CDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLW
EMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCE
TLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK



Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston Rights Reserved
Site Policies | State of Texas