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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 7048 |
Name | TGFBR2 |
Synonymous | AAT3|FAA3|LDS1B|LDS2B|MFS2|RIIC|TAAD2|TGFR-2|TGFbeta-RII;transforming growth factor, beta receptor II (70/80kDa);TGFBR2;transforming growth factor, beta receptor II (70/80kDa) |
Definition | TGF-beta receptor type II|TGF-beta receptor type IIB|TGF-beta receptor type-2|TGF-beta type II receptor|tbetaR-II|transforming growth factor beta receptor type IIC|transforming growth factor, beta receptor II (70/80kDa) isoform 1|transforming growth facto |
Position | 3p22 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
TGFbetaR-II(h) + ATP --> TGFbetaR-II(h){p} + ADP (phosphorylation; automodification) | TGFbeta1(h) + TGFbetaR-II(h) + TGFbetaR-I(h) <==> TGFbeta1(h):TGFbetaR-II(h):TGFbetaR-I(h) (binding) | TGFbeta1(pg) + TGFbetaR-II(h) + TGFbetaR-I(mv) <==> TGFbeta1(pg):TGFbetaR-II(h):TGFbetaR-I(mv) (binding) | TGFbeta2(pg) + TGFbetaR-II(h) + TGFbetaR-I(mv) <==> TGFbeta2(pg):TGFbetaR-II(h):TGFbetaR-I(mv) (binding) | TGFbeta3(h) + TGFbetaR-II(h) + TGFbetaR-I(mv) <==> TGFbeta3(h):TGFbetaR-II(h):TGFbetaR-I(mv) (binding) | TGFbeta1(pg) + TGFbetaR-II(h) + ALK-1(h) <==> TGFbeta1(pg):TGFbetaR-II(h):ALK-1(h) (binding) | TGFbetaR-II(h) + TGFbetaR-I(h) + Smad2-L(h) <==> TGFbetaR-II(h):TGFbetaR-I(h):Smad2-L(h) (binding) | TGFbeta1(h) + TGFbetaR-III(h) + TGFbetaR-II(h) <==> TGFbeta1(h):TGFbetaR-III(h):TGFbetaR-II(h) (binding) | TGFbeta1(pg) + TGFbetaR-II(h) + TGFbetaR-I(h) <==> TGFbeta1(pg):TGFbetaR-II(h):TGFbetaR-I(h) (binding) | TGFbeta1(v.s.) + TGFbetaR-II(h) + ALK-1(h) <==> TGFbeta1(v.s.):TGFbetaR-II(h):ALK-1(h) (binding) | TGFbeta1(v.s.) + TGFbetaR-II(h) + TGFbetaR-I(h) <==> TGFbeta1(v.s.):TGFbetaR-II(h):TGFbetaR-I(h) (binding) | (TGFbeta3(h))2 + TGFbetaR-II(h) <==> (TGFbeta3(h))2:TGFbetaR-II(h) (binding) | TGFbeta1(v.s.) + TGFbetaR-II(h) <==> TGFbeta1(v.s.):TGFbetaR-II(h) (binding) | TGFbetaR-II(h) + TGFbetaR-I(h) + ATP --> TGFbetaR-II(h){p} + TGFbetaR-I(h){p} + ADP (phosphorylation) | TGFbeta1(v.s.) + TGFbetaR-II(h) + TGFbetaR-I(h) + Dnlc2a(h) <==> TGFbeta1(v.s.):TGFbetaR-II(h):TGFbetaR-I(h):Dnlc2a(h) (binding) | TGFbetaR-II(h) + Dnlc2a(h) <==> TGFbetaR-II(h):Dnlc2a(h) (binding) | TGFbeta1(h) + TGFbetaR-II(h) <==> TGFbeta1(h):TGFbetaR-II(h) (binding) | TGFbeta3(h) + TGFbetaR-II(h) <==> TGFbeta3(h):TGFbetaR-II(h) (binding) | TGFbeta2(h) + TGFbetaR-III(r) + TGFbetaR-II(h) <==> TGFbeta2(h):TGFbetaR-III(r):TGFbetaR-II(h) (binding) | TGFbetaR-II(h) + endoglin(h) <==> TGFbetaR-II(h):endoglin(h) (binding) | TGFbetaR-II(h) + Daxx(h) <==> TGFbetaR-II(h):Daxx(h) (binding). | TGFbetaR-II(h) + Daxx(m) <==> TGFbetaR-II(h):Daxx(m) (binding). | (TGFbeta1(h))2 + 2 TGFbetaR-II(h) <==> (TGFbeta1(h))2:(TGFbetaR-II(h))2 (binding) | (TGFbeta1(h))2 + TGFbetaR-II(h) + TGFbetaR-I(h) <==> (TGFbeta1(h))2:TGFbetaR-II(h):TGFbetaR-I(h) (binding) | TGFbetaR-II(h) + ATP --> TGFbetaR-II(h){pS213} + ADP (phosphorylation; automodification) | 2 TGFbetaR-II(h) + 2 ATP --TGFbetaR-II(h)--> TGFbetaR-II(h){pS409} + TGFbetaR-II(h){pS416} + 2 ADP (phosphorylation) | 2 TGFbetaR-II(h) <==> (TGFbetaR-II(h))2 (binding) | TGFbetaR-II(h) + Dab2(h) <==> TGFbetaR-II(h):Dab2(h) (binding) | TGFbetaR-II(h) + SNX2(h) <==> TGFbetaR-II(h):SNX2(h) (binding) | TGFBR2(h) --> TGFbetaR-II(h) (expression). | endoglin(h) + ATP --TGFbetaR-II(h)--> endoglin(h){p} + ADP (phosphorylation) | 2 TGFbetaR-II(h) + 2 ATP --TGFbetaR-II(h)--> TGFbetaR-II(h){pS409} + TGFbetaR-II(h){pS416} + 2 ADP (phosphorylation) | TGFBR2(h) --> TGFbetaR-II(h) (expression). |
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Post Transcriptional Modification From dbPTM | | Top | |
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Location (AA) |
PTM type |
Literature |
Database |
70 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 94 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 154 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 548 | Phosphoserine. | Swiss-Prot 53.0 | 336 | Phosphotyrosine (TGFbR2) | 9169454 | Phospho.ELM 6.0 | 424 | Phosphotyrosine (TGFbR2) | 9169454 | Phospho.ELM 6.0 | 409 | Phosphoserine (TGFbR2) | 9155023 | Phospho.ELM 6.0 | 416 | Phosphoserine (TGFbR2) | 9155023 | Phospho.ELM 6.0 | 259 | Phosphotyrosine (TGFbR2) | 9169454 | Phospho.ELM 6.0 | 213 | Phosphoserine (TGFbR2) | 9155023 | Phospho.ELM 6.0 | 548 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
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Chromosome |
Location |
Source |
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chr3 |
Promoter: 30621498 - 30623498 | Agilent_014791 |
chr3 |
Promoter: 30621498 - 30623498 | GSE27584 |
chr3 |
Promoter: 30621498 - 30623498 | GSE27584 |
chr3 |
Promoter: 30621498 - 30623498 | Agilent_014791_44K |
chr3 |
Promoter: 30621498 - 30623498 | PMID:15172987 |
chr3 |
Promoter: 30621498 - 30623498 | PMID:15172987 |
chr3 |
Promoter: 30621498 - 30623498 | PMID:15895377 |
chr3 |
Promoter: 30621498 - 30623498 | PMID:15895377 |