Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

7068

Name

THRB

Synonym

C-ERBA-2|C-ERBA-BETA|ERBA2|GRTH|NR1A2|PRTH|THR1|THRB1|THRB2;thyroid hormone receptor, beta;THRB;thyroid hormone receptor, beta

Definition

nuclear receptor subfamily 1 group A member 2|oncogene ERBA2|thyroid hormone nuclear receptor beta variant 1|thyroid hormone receptor beta|thyroid hormone receptor beta 1|thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene hom

Position

3p24.2

Gene Type

protein-coding

Source

Count: 1; Generif

Literature support

Count: 3 PubMed records as below.

Evidence Status

Description

reviewed

"microRNAs up-regulated in papillary thyroid carcinoma tumors directly inhibit the expression of THRB, an important tumor suppressor gene".

reviewed

TRs could function as tumor suppressors in a mouse model of metastatic follicular thyroid cancer.

reviewed

TRbeta gene could function as a tumor suppressor gene. TRbeta could serve as a novel therapeutic target in thyroid cancer.
More detail of all 3 literatures about THRB

Pathways and Diseases

Pathway

map kinase inactivation of smrt corepressor;PID BioCarta;100032

Pathway

Neuroactive ligand-receptor interaction;KEGG PATHWAY;hsa04080

Pathway

Gene Expression;Reactome;REACT:71

Disease

Thyroid hormone resistance;OMIM

Disease

PSYCH;GAD

Disease

ADHD;GAD

Disease

Thyroid hormone resistance, selective pituitary;OMIM

Disease

IMMUNE;GAD

Disease

Thyroid hormone resistance, autosomal recessive;OMIM

Disease

Hematological and biochemical traits;NHGRI

Disease

METABOLIC;GAD

Disease

Graves disease;GAD

Disease

resistance to thyroid hormone;GAD

Disease

hormone disturbance;GAD

External Links

Links to Entrez Gene

7068

Links to all GeneRIF Items

7068

Links to iHOP

7068

Sequence Information

Nucleotide Sequence

>7068 : length: 1386
atgactcccaacagtatgacagaaaatggccttacagcctgggacaaaccgaagcactgt
ccagaccgagaacacgactggaagctagtaggaatgtctgaagcctgcctacataggaag
agccattcagagaggcgcagcacgttgaaaaatgaacagtcgtcgccacatctcatccag
accacttggactagctcaatattccatctggaccatgatgatgtgaacgaccagagtgtc
tcaagtgcccagaccttccaaacggaggagaagaaatgtaaagggtacatccccagttac
ttagacaaggacgagctctgtgtagtgtgtggtgacaaagccaccgggtatcactaccgc
tgtatcacgtgtgaaggctgcaagggtttctttagaagaaccattcagaaaaatctccat
ccatcctattcctgtaaatatgaaggaaaatgtgtcatagacaaagtcacgcgaaatcag
tgccaggaatgtcgctttaagaaatgcatctatgttggcatggcaacagatttggtgctg
gatgacagcaagaggctggccaagaggaagctgatagaggagaaccgggagaaaagacgg
cgggaagagctgcagaagtccatcgggcacaagccagagcccacagacgaggaatgggag
ctcatcaaaactgtcaccgaagcccatgtggcgaccaacgcccaaggcagccactggaag
caaaaacggaaattcctgccagaagacattggacaagcaccaatagtcaatgccccagaa
ggtggaaaggttgacttggaagccttcagccattttacaaaaatcatcacaccagcaatt
accagagtggtggattttgccaaaaagttgcctatgttttgtgagctgccatgtgaagac
cagatcatcctcctcaaaggctgctgcatggagatcatgtcccttcgcgctgctgtgcgc
tatgacccagaaagtgagactttaaccttgaatggggaaatggcagtgacacggggccag
ctgaaaaatgggggtcttggggtggtgtcagacgccatctttgacctgggcatgtctctg
tcttctttcaacctggatgacactgaagtagccctccttcaggccgtcctgctgatgtct
tcagatcgcccggggcttgcctgtgttgagagaatagaaaagtaccaagatagtttcctg
ctggcctttgaacactatatcaattaccgaaaacaccacgtgacacacttttggccaaaa
ctcctgatgaaggtgacagatctgcggatgataggagcctgccatgccagccgcttcctg
cacatgaaggtggaatgccccacagaactcttcccccctttgttcttggaagtgttcgag
gattag

Protein Sequence

>7068 : length: 461
MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED



Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston Rights Reserved
Site Policies | State of Texas