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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 7068 |
Name | THRB |
Synonymous | C-ERBA-2|C-ERBA-BETA|ERBA2|GRTH|NR1A2|PRTH|THR1|THRB1|THRB2;thyroid hormone receptor, beta;THRB;thyroid hormone receptor, beta |
Definition | nuclear receptor subfamily 1 group A member 2|oncogene ERBA2|thyroid hormone nuclear receptor beta variant 1|thyroid hormone receptor beta|thyroid hormone receptor beta 1|thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene hom |
Position | 3p24.2 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
bag1-xbb1(h) + T3R-beta1(h) <==> bag1-xbb1(h):T3R-beta1(h) (binding) | T3R-beta1(h) --> GH(r) (DNA binding). | T3R-beta1(h) --> MHC-A(r) (DNA binding; transregulation). | T3R-beta1(h) --> Me1(r) (DNA binding; transregulation). | T3R-beta1(h) --> VIT-A2(x) (DNA binding). | T3R-beta1(h) --> Mo-MuLV(MOMLV) (DNA binding). | T3R-beta1(h) --> TSHB(h) (DNA binding; transregulation). | T3R-beta1(h) --> MYH6(h) (DNA binding). | T3R-beta1(h) --> CGA(h) (DNA binding). | T3R-beta1(h) --> EGFR(h) (DNA binding). | T3R-beta1(h) + RXR-alpha(h) <==> T3R-beta1(h):RXR-alpha(h) (binding). | RXR-alpha(m) + T3R-beta1(h) <==> RXR-alpha(m):T3R-beta1(h) (binding). | RXR-beta(r) + T3R-beta1(h) <==> RXR-beta(r):T3R-beta1(h) (binding). | TRAP(h) + T3R-beta1(h) <==> TRAP(h):T3R-beta1(h) (binding). | RXR-alpha(x) + T3R-beta1(h) <==> RXR-alpha(x):T3R-beta1(h) (binding). | LXR-beta(r) + T3R-beta1(h) <==> LXR-beta(r):T3R-beta1(h) (binding). | SRC3(h) + T3R-beta1(h) <==> SRC3(h):T3R-beta1(h) (binding). | NCOR1(m) + T3R-beta1(h) <==> NCOR1(m):T3R-beta1(h) (binding) | ZAC-1b(m) + T3R-beta1(h) <==> ZAC-1b(m):T3R-beta1(h) (binding) | ADA2(h) + T3R-beta1(h) <==> ADA2(h):T3R-beta1(h) (binding) | T3R-beta1(h) + TIF2(m) <==> T3R-beta1(h):TIF2(m) (binding) | T3R-beta1(h) + GCN5(h) <==> T3R-beta1(h):GCN5(h) (binding) | GT198(r) + T3R-beta1(h) <==> GT198(r):T3R-beta1(h) (binding) | ER(m.s.) + T3R-beta1(h) <==> ER(m.s.):T3R-beta1(h) (binding) | ctcf(m) + T3R-beta1(h) <==> ctcf(m):T3R-beta1(h) (binding) | T3R-beta1(h) --> p53(h) (increase of abundance) | cyclinD1(m.s.) + T3R-beta1(h) <==> cyclinD1(m.s.):T3R-beta1(h) (binding) | T3R-beta1(h) + cyclinD1(m.s.) + HDAC3-isoform1(h) <==> T3R-beta1(h):cyclinD1(m.s.):HDAC3-isoform1(h) (binding) | T3R-beta1(h) + hdac2(m) <==> T3R-beta1(h):hdac2(m) (binding) | ASC-1(h) + T3R-beta1(h) <==> ASC-1(h):T3R-beta1(h) (binding) | ASC-1(h) + T3R-beta1(h) <==> ASC-1(h):T3R-beta1(h) (binding) | T3R-beta1(h) + SRC-1A(h) <==> T3R-beta1(h):SRC-1A(h) (binding) | T3R-beta1(h) + PGC-1(h) <==> T3R-beta1(h):PGC-1(h) (binding) | NCOR1-isoform1(m) + T3R-beta1(h) <==> NCOR1-isoform1(m):T3R-beta1(h) (binding) | EAR2(h) + T3R-beta1(h) <==> EAR2(h):T3R-beta1(h) (binding) | EAR2(h) + T3R-beta1(h) <==> EAR2(h):T3R-beta1(h) (binding) | T3R-beta1(h) + NCOR1(h) <==> T3R-beta1(h):NCOR1(h) (binding) | SMRT(h) + T3R-beta1(h) <==> SMRT(h):T3R-beta1(h) (binding) | T3R-beta1(h) + TIF2(m.s.) <==> T3R-beta1(h):TIF2(m.s.) (binding) | T3R-beta1(h) --/ Srebf1(m) (transrepression) | T3R-beta1(h) --> Apoa5(h) (transactivation) | T3R-beta1(h) --> Trh(m) (DNA binding). | T3R-beta1(h) --> Gh1(r) (DNA binding). | T3R-beta1(h) --> ATP1B1(h) (DNA binding). | T3R-beta1(h) --> Tshb(m) (DNA binding). | THRB(h) --> T3R-beta1(h) (expression). | T3R-beta2(h) + cyclinD1(m.s.) <==> T3R-beta2(h):cyclinD1(m.s.) (binding) | THRB(h) --> T3R-beta2(h) (expression). | T3R-beta(h) + SET-isoform2(h) <==> T3R-beta(h):SET-isoform2(h) (binding) | T3R-beta(h) + TFIIB(h) <==> T3R-beta(h):TFIIB(h) (binding) | trip11(h) + T3R-beta(h) <==> trip11(h):T3R-beta(h) (binding) | SRB7(h) + T3R-beta(h) <==> SRB7(h):T3R-beta(h) (binding) | SRC-1(m.s.) + T3R-beta(h) <==> SRC-1(m.s.):T3R-beta(h) (binding) | ASC-2(r) + T3R-beta(h) <==> ASC-2(r):T3R-beta(h) (binding) | ASC-2(h) + T3R-beta(h) <==> ASC-2(h):T3R-beta(h) (binding) | T3R-beta(h) + RXR-alpha(h) <==> T3R-beta(h):RXR-alpha(h) (binding) | T3R-beta(h) + Alien(h) <==> T3R-beta(h):Alien(h) (binding) | T3R-beta(h) + RIP140(h) <==> T3R-beta(h):RIP140(h) (binding) | CBP(m) + T3R-beta(h) + SRC-1(m.s.) <==> CBP(m):T3R-beta(h):SRC-1(m.s.) (binding) | T3R-beta(h) + SRC3-xbb2(h) <==> T3R-beta(h):SRC3-xbb2(h) (binding) | T3R-beta(h) + FOXO1A(h) <==> T3R-beta(h):FOXO1A(h) (binding) | NCOR1-isoform1(m) + T3R-beta(h) <==> NCOR1-isoform1(m):T3R-beta(h) (binding) | TIF2(m) + T3R-beta(h) <==> TIF2(m):T3R-beta(h) (binding) | T3R-beta(h) --> apoC-II(h) (DNA binding). | ASC-2(m) + T3R-beta(h) <==> ASC-2(m):T3R-beta(h) (binding) | T3 + T3R-beta(h) <==> T3:T3R-beta(h) (binding) | SRC-1(h) + T3R-beta(h) <==> SRC-1(h):T3R-beta(h) (binding) | T3R-beta(h) + SRC3(h) <==> T3R-beta(h):SRC3(h) (binding) | T3R-beta(h) + TRIP7(h) <==> T3R-beta(h):TRIP7(h) (binding) | T3R-beta(h) + RIP140(h) <==> T3R-beta(h):RIP140(h) (binding) | T3R-beta(h) + CaMKII-beta(h) <==> T3R-beta(h):CaMKII-beta(h) (binding) | T3R-beta(h) + S8(h) <==> T3R-beta(h):S8(h) (binding) | T3R-beta(h) + RXR-alpha(h) <==> T3R-beta(h):RXR-alpha(h) (binding) | T3R-beta(h) --> Cyp7a1(r) (transactivation) | T3R-beta(h) --/ PTGDS(h) (transrepression) | T3R-beta(h) --> Nr4a1(m) (DNA binding). | T3R-beta(h) --> Tshb(r) (DNA binding; transactivation). | rT3 + T3R-beta(h) <==> rT3:T3R-beta(h) (binding) | Triac + T3R-beta(h) <==> Triac:T3R-beta(h) (binding) | L-thyroxine + T3R-beta(h) <==> L-thyroxine:T3R-beta(h) (binding) | Tetrac + T3R-beta(h) <==> Tetrac:T3R-beta(h) (binding) | THRB(h) --> T3R-beta(h) (expression). | TIF2(m.s.) --> T3R-beta(h) (activation) |
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Post Transcriptional Modification From dbPTM | | Top | |
There is no record for THRB |
Methylation Profile From DiseaseMeth database | | Top | |
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Chromosome |
Location |
Source |
|---|---|---|
chr3 |
Promoter: 24510817 - 24512817 | Agilent_014791 |
chr3 |
Promoter: 24510817 - 24512817 | GSE27584 |
chr3 |
Promoter: 24510817 - 24512817 | Agilent_014791_44K |