|
|
||
|
|
||
| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 7128 |
Name | TNFAIP3 |
Synonym | A20|OTUD7C|TNFA1P2;tumor necrosis factor, alpha-induced protein 3;TNFAIP3;tumor necrosis factor, alpha-induced protein 3 |
Definition | OTU domain-containing protein 7C|TNF alpha-induced protein 3|TNFAIP3 (A20)|putative DNA-binding protein A20|tumor necrosis factor alpha-induced protein 3|tumor necrosis factor inducible protein A20|zinc finger protein A20 |
Position | 6q23 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 7 PubMed records as below. |
|
Evidence Status |
Description |
reviewed | tumor suppressor TNFAIP3 (A20) is frequently deleted in Sézary syndrome. |
reviewed | tumor suppressor A20 protects against cardiac hypertrophy and fibrosis by blocking transforming growth factor-beta-activated kinase 1-dependent signaling. |
reviewed | Mutation analysis of the TNFAIP3 (A20) tumor suppressor gene in chronic lymphocytic leukemia. |
reviewed | TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas. |
reviewed | TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma. |
potential | May act as a tumor suppressor gene in ocular adnexal marginal zone B cell lymphoma; loss of this gene may play an important role in lymphomagenesis. |
reviewed | B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice. |
| More detail of all 7 literatures about TNFAIP3 | |
|
Pathways and Diseases |
|
Pathway | TNF receptor signaling pathway;PID Curated;200086 |
Pathway | NOD-like receptor signaling pathway;KEGG PATHWAY;hsa04621 |
Pathway | cd40l signaling pathway;PID BioCarta;100213 |
Pathway | CD40/CD40L signaling;PID Curated;200031 |
Pathway | Canonical NF-kappaB pathway;PID Curated;200026 |
Pathway | Toll receptor signaling pathway;PANTHER;P00054 |
Pathway | tnfr2 signaling pathway;PID BioCarta;100014 |
Disease | IMMUNE;GAD |
Disease | Wegener's granulomatosis;GAD |
Disease | Celiac disease;NHGRI |
Disease | atherosclerosis, coronary;GAD |
Disease | Celiac Disease;GAD |
Disease | Psoriasis;NHGRI |
Disease | CARDIOVASCULAR;GAD |
Disease | psoriasis;GAD |
Disease | Rheumatoid arthritis;NHGRI |
Disease | Systemic lupus erythematosus;NHGRI |
Disease | rheumatoid arthritis;GAD |
Disease | systemic lupus erythematosus;GAD |
|
External Links |
|
Links to Entrez Gene | 7128 |
Links to all GeneRIF Items | 7128 |
Links to iHOP | 7128 |
|
Sequence Information |
|
Nucleotide Sequence |
>7128 : length: 2373 atggctgaacaagtccttcctcaggctttgtatttgagcaatatgcggaaagctgtgaag atacgggagagaactccagaagacatttttaaacctactaatgggatcattcatcatttt aaaaccatgcaccgatacacactggaaatgttcagaacttgccagttttgtcctcagttt cgggagatcatccacaaagccctcatcgacagaaacatccaggccaccctggaaagccag aagaaactcaactggtgtcgagaagtccggaagcttgtggcgctgaaaacgaacggtgac ggcaattgcctcatgcatgccacttctcagtacatgtggggcgttcaggacacagacttg gtactgaggaaggcgctgttcagcacgctcaaggaaacagacacacgcaactttaaattc cgctggcaactggagtctctcaaatctcaggaatttgttgaaacggggctttgctatgat actcggaactggaatgatgaatgggacaatcttatcaaaatggcttccacagacacaccc atggcccgaagtggacttcagtacaactcactggaagaaatacacatatttgtcctttgc aacatcctcagaaggccaatcattgtcatttcagacaaaatgctaagaagtttggaatca ggttccaatttcgcccctttgaaagtgggtggaatttacttgcctctccactggcctgcc caggaatgctacagataccccattgttctcggctatgacagccatcattttgtacccttg gtgaccctgaaggacagtgggcctgaaatccgagctgttccacttgttaacagagaccgg ggaagatttgaagacttaaaagttcactttttgacagatcctgaaaatgagatgaaggag aagctcttaaaagagtacttaatggtgatagaaatccccgtccaaggctgggaccatggc acaactcatctcatcaatgccgcaaagttggatgaagctaacttaccaaaagaaatcaat ctggtagatgattactttgaacttgttcagcatgagtacaagaaatggcaggaaaacagc gagcaggggaggagagaggggcacgcccagaatcccatggaaccttccgtgccccagctt tctctcatggatgtaaaatgtgaaacgcccaactgccccttcttcatgtctgtgaacacc cagcctttatgccatgagtgctcagagaggcggcaaaagaatcaaaacaaactcccaaag ctgaactccaagccgggccctgaggggctccctggcatggcgctcggggcctctcgggga gaagcctatgagcccttggcgtggaaccctgaggagtccactggggggcctcattcggcc ccaccgacagcacccagcccttttctgttcagtgagaccactgccatgaagtgcaggagc cccggctgccccttcacactgaatgtgcagcacaacggattttgtgaacgttgccacaac gcccggcaacttcacgccagccacgccccagaccacacaaggcacttggatcccgggaag tgccaagcctgcctccaggatgttaccaggacatttaatgggatctgcagtacttgcttc aaaaggactacagcagaggcctcctccagcctcagcaccagcctccctccttcctgtcac cagcgttccaagtcagatccctcgcggctcgtccggagcccctccccgcattcttgccac agagctggaaacgacgcccctgctggctgcctgtctcaagctgcacggactcctggggac aggacggggacgagcaagtgcagaaaagccggctgcgtgtattttgggactccagaaaac aagggcttttgcacactgtgtttcatcgagtacagagaaaacaaacattttgctgctgcc tcagggaaagtcagtcccacagcgtccaggttccagaacaccattccgtgcctggggagg gaatgcggcacccttggaagcaccatgtttgaaggatactgccagaagtgtttcattgaa gctcagaatcagagatttcatgaggccaaaaggacagaagagcaactgagatcgagccag cgcagagatgtgcctcgaaccacacaaagcacctcaaggcccaagtgcgcccgggcctcc tgcaagaacatcctggcctgccgcagcgaggagctctgcatggagtgtcagcatcccaac cagaggatgggccctggggcccaccggggtgagcctgcccccgaagacccccccaagcag cgttgccgggcccccgcctgtgatcattttggcaatgccaagtgcaacggctactgcaac gaatgctttcagttcaagcagatgtatggctaa |
Protein Sequence |
>7128 : length: 790 MAEQVLPQALYLSNMRKAVKIRERTPEDIFKPTNGIIHHFKTMHRYTLEMFRTCQFCPQF REIIHKALIDRNIQATLESQKKLNWCREVRKLVALKTNGDGNCLMHATSQYMWGVQDTDL VLRKALFSTLKETDTRNFKFRWQLESLKSQEFVETGLCYDTRNWNDEWDNLIKMASTDTP MARSGLQYNSLEEIHIFVLCNILRRPIIVISDKMLRSLESGSNFAPLKVGGIYLPLHWPA QECYRYPIVLGYDSHHFVPLVTLKDSGPEIRAVPLVNRDRGRFEDLKVHFLTDPENEMKE KLLKEYLMVIEIPVQGWDHGTTHLINAAKLDEANLPKEINLVDDYFELVQHEYKKWQENS EQGRREGHAQNPMEPSVPQLSLMDVKCETPNCPFFMSVNTQPLCHECSERRQKNQNKLPK LNSKPGPEGLPGMALGASRGEAYEPLAWNPEESTGGPHSAPPTAPSPFLFSETTAMKCRS PGCPFTLNVQHNGFCERCHNARQLHASHAPDHTRHLDPGKCQACLQDVTRTFNGICSTCF KRTTAEASSSLSTSLPPSCHQRSKSDPSRLVRSPSPHSCHRAGNDAPAGCLSQAARTPGD RTGTSKCRKAGCVYFGTPENKGFCTLCFIEYRENKHFAAASGKVSPTASRFQNTIPCLGR ECGTLGSTMFEGYCQKCFIEAQNQRFHEAKRTEEQLRSSQRRDVPRTTQSTSRPKCARAS CKNILACRSEELCMECQHPNQRMGPGAHRGEPAPEDPPKQRCRAPACDHFGNAKCNGYCN ECFQFKQMYG |