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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 7414 |
Name | VCL |
Synonym | CMD1W|CMH15|MVCL;vinculin;VCL;vinculin |
Definition | metavinculin |
Position | 10q22.2 |
Gene Type | protein-coding |
Source | Count: 1; TAG |
Literature support | Count: 0 PubMed records as below. |
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Evidence Status |
Description |
| . |
| More detail of all 0 literatures about VCL | |
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Pathways and Diseases |
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Pathway | Bacterial invasion of epithelial cells;KEGG PATHWAY;hsa05100 |
Pathway | Adherens junction;KEGG PATHWAY;hsa04520 |
Pathway | Amoebiasis;KEGG PATHWAY;hsa05146 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | erk and pi-3 kinase are necessary for collagen binding in corneal epithelia;PID BioCarta;100184 |
Pathway | Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | rho cell motility signaling pathway;PID BioCarta;100041 |
Pathway | Signaling events mediated by VEGFR1 and VEGFR2;PID Curated;200161 |
Pathway | integrin signaling pathway;PID BioCarta;100123 |
Pathway | Signaling events mediated by focal adhesion kinase;PID Curated;200192 |
Pathway | Integrins in angiogenesis;PID Curated;200109 |
Pathway | RhoA signaling pathway;PID Curated;200007 |
Pathway | Shigellosis;KEGG PATHWAY;hsa05131 |
Pathway | Leukocyte transendothelial migration;KEGG PATHWAY;hsa04670 |
Pathway | Muscle contraction;Reactome;REACT:17044 |
Pathway | Integrin signalling pathway;PANTHER;P00034 |
Pathway | Stabilization and expansion of the E-cadherin adherens junction;PID Curated;200155 |
Pathway | cell to cell adhesion signaling;PID BioCarta;100208 |
Disease | Cardiomyopathy, familial hypertrophic, 15;OMIM |
Disease | Cardiomyopathy, dilated, 1W;OMIM |
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External Links |
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Links to Entrez Gene | 7414 |
Links to all GeneRIF Items | 7414 |
Links to iHOP | 7414 |
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Sequence Information |
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Nucleotide Sequence |
>7414 : length: 3201 atgccagtgtttcatacgcgcacgatcgagagcatcctggagccggtggcacagcagatc tcccacctggtgataatgcacgaggagggcgaggtggacggcaaagccattcctgacctc accgcgcccgtggccgccgtgcaggcggccgtcagcaacctcgtccgggttggaaaagag actgttcaaaccactgaggatcagattttgaagagagatatgccaccagcatttattaag gttgagaatgcttgcaccaagcttgtccaggcagctcagatgcttcagtcagacccttac tcagtgcctgctcgagattatctaattgatgggtcaaggggcatcctctctggaacatca gacctgctccttaccttcgatgaggctgaggtccgtaaaattattagagtttgcaaagga attttggaatatcttacagtggcagaggtggtggagactatggaagatttggtcacttac acaaagaatcttgggccaggaatgactaagatggccaagatgattgacgagagacagcag gagctcactcaccaggagcaccgagtgatgttggtgaactcgatgaacaccgtgaaagag ttgctgccagttctcatttcagctatgaagatttttgtaacaactaaaaactcaaaaaac caaggcatagaggaagctttaaaaaatcgcaattttactgtagaaaaaatgagtgctgaa attaatgagataattcgtgtgttacaactcacctcttgggatgaagatgcctgggccagc aaggacactgaagccatgaagagagcattggcctccatagactccaaactgaaccaggcc aaaggttggctccgtgaccctagtgcctccccaggggatgctggtgagcaggccatcaga cagatcttagatgaagctggaaaagttggtgaactctgtgcaggcaaagaacgcagggag attctgggaacttgcaaaatgctagggcagatgactgatcaagtggctgacctccgtgcc agaggacaaggatcctcaccggtggccatgcagaaagctcagcaggtatctcagggtctg gatgtgctcacagcaaaagtggaaaatgcagctcgcaagctggaagccatgaccaactca aagcagagcattgcaaagaagatcgatgctgctcagaactggcttgcagatccaaatggt ggaccggaaggagaagagcagattcgaggtgctttggctgaagctcggaaaatagcagaa ttatgtgatgatcctaaagaaagagatgacattctacgttcccttggggaaatatctgct ctgacttctaaattagcagatctacgaagacaggggaaaggagattctccagaggctcga gccttggccaaacaggtggccacggccctgcagaacctgcagaccaaaaccaaccgggct gtggccaacagcagaccggccaaagcagctgtacaccttgagggcaagattgagcaagca cagcggtggattgataatcccacagtggatgaccgtggagtcggtcaggctgccatccgg gggcttgtggccgaagggcatcgtctggctaatgttatgatggggccttatcggcaagat cttctcgccaagtgtgaccgagtggaccagctgacagcccagctggctgacctggctgcc agaggggaaggggagagtcctcaggcacgagcacttgcatctcagctccaagactcctta aaggatctaaaagctcggatgcaggaggccatgactcaggaagtgtcagatgttttcagc gataccacaactcccatcaagctgttggcagtggcagccacggcgcctcctgatgcgcct aacagggaagaggtatttgatgagagggcagctaactttgaaaaccattcaggaaagctt ggtgctacggccgagaaggcggctgcggttggtactgctaataaatcaacagtggaaggc attcaggcctcagtgaagacggcccgagaactcacaccccaggtggtctcggctgctcgt atcttacttaggaaccctggaaatcaagctgcttatgaacattttgagaccatgaagaac cagtggatcgataatgttgaaaaaatgacagggctggtggacgaagccattgataccaaa tctctgttggatgcttcagaagaagcaattaaaaaagacctggacaagtgcaaggtagct atggccaacattcagcctcagatgctggttgctggggcaaccagtattgctcgtcgggcc aaccggatcctgctggtggctaagagggaggtggagaattccgaggatcccaagttccgt gaggctgtgaaagctgcctctgatgaattgagcaaaaccatctccccgatggtgatggat gcaaaagctgtggctggaaacatttccgaccctggactgcaaaagagcttcctggactca ggatatcggatcctgggagctgtggccaaggtcagagaagccttccaacctcaggagcct gacttcccgccgcctccaccagaccttgaacaactccgactaacagatgagcttgctcct cccaaaccacctctgcctgaaggtgaggtccctccacctaggcctccaccaccagaggaa aaggatgaagagttccctgagcagaaggccggggaggtgattaaccagccaatgatgatg gctgccagacagctccatgatgaagctcgcaaatggtccagcaagggcaatgacatcatt gcagcagccaagcgcatggctctgctgatggctgagatgtctcggctggtaagagggggc agtggtaccaagcgggcactcattcagtgtgccaaggacatcgccaaggcctcagatgag gtgactcggttggccaaggaggttgccaagcagtgcacagataaacggattagaaccaac ctcttacaggtatgtgagcgaatcccaaccataagcacccagctcaaaatcctgtccaca gtgaaggccaccatgctgggccggaccaacatcagtgatgaggagtctgagcaggccaca gagatgctggttcacaatgcccagaacctcatgcagtctgtgaaggagactgtgcgggaa gctgaagctgcttcaatcaaaattcgaacagatgctggatttacactgcgctgggttaga aagactccctggtaccagtag |
Protein Sequence |
>7414 : length: 1066 MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKE TVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTS DLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQ ELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAE INEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIR QILDEAGKVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGL DVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAE LCDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRA VANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQD LLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMTQEVSDVFS DTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEG IQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAIDTK SLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFR EAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEP DFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPMMM AARQLHDEARKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQCAKDIAKASDE VTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQAT EMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWVRKTPWYQ |