Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

7414

Name

VCL

Synonymous

CMD1W|CMH15|MVCL;vinculin;VCL;vinculin

Definition

metavinculin

Position

10q22.2

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors

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Regulation From TransFac database

FAK1(h) + vinculin(h) <==> FAK1(h):vinculin(h) (binding)
vinculin(h) + ATP --> vinculin(h){pY} + ADP (phosphorylation)
trip6(h) + vinculin(h) <==> trip6(h):vinculin(h) (binding)
vinculin(h) + abi2(h) <==> vinculin(h):abi2(h) (binding)
vinculin(h) + c19orf57(h) <==> vinculin(h):c19orf57(h) (binding)
VCL(h) --> vinculin(h) (expression).
VCL(h) --> Vinculin-isoform1(h) (expression).
VCL(h) --> Vinculin-isoform2(h) (expression).

Post Transcriptional Modification From dbPTM

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Location (AA)

PTM type

Literature

Database

290Phosphoserine.Swiss-Prot 53.0
508Phosphothreonine.Swiss-Prot 53.0
537Phosphotyrosine (Potential).Swiss-Prot 53.0
604Phosphothreonine.Swiss-Prot 53.0
721Phosphoserine.Swiss-Prot 53.0
822Phosphotyrosine (Probable).Swiss-Prot 53.0
1100Phosphoserine (PKC alpha)11741957Phospho.ELM 6.0
1112Phosphoserine (PKC alpha)11741957Phospho.ELM 6.0
507Phosphothreonine16097034Phospho.ELM 6.0
1132Phosphotyrosine15229287Phospho.ELM 6.0

Methylation Profile From DiseaseMeth database

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Chromosome

Location

Source

chr10

Promoter: 75426378 - 75428378Agilent_014791

chr10

Promoter: 75426378 - 75428378GSE27584

chr10

Promoter: 75426378 - 75428378GSE27584

chr10

Promoter: 75426378 - 75428378Agilent_014791_44K


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