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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 8289 |
Name | ARID1A |
Synonym | B120|BAF250|BAF250a|BM029|C1orf4|ELD|OSA1|P270|SMARCF1|hELD|hOSA1;AT rich interactive domain 1A (SWI-like);ARID1A;AT rich interactive domain 1A (SWI-like) |
Definition | ARID domain-containing protein 1A|AT-rich interactive domain-containing protein 1A|BRG1-associated factor 250a|OSA1 nuclear protein|SWI-like protein|SWI/SNF complex protein p270|SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin su |
Position | 1p35.3 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 4 PubMed records as below. |
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Evidence Status |
Description |
reviewed | ARID1A is a bona fide tumor suppressor that collaborates with p53 to regulate CDKN1A and SMAD3 transcription and tumor growth in gynecologic cancers. |
reviewed | These data implicate ARID1A as a tumor-suppressor gene frequently disrupted in ovarian clear-cell and endometrioid carcinomas. |
potential | "genes mutated in ovarian clear cell carcinoma(OCCC);data suggest PPP2R1A functions as an oncogene and ARID1A as tumor-suppressor gene; in 42 OCCCs, 7% had mutations in PPP2R1A and 57% in ARID1A; suggests aberrant chromatin remodeling contributes to OCCC". |
reviewed | Genomic and functional evidence for an ARID1A tumor suppressor role. |
| More detail of all 4 literatures about ARID1A | |
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Pathways and Diseases |
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Pathway | chromatin remodeling by hswi/snf atp-dependent complexes;PID BioCarta;100141 |
Pathway | the information processing pathway at the ifn beta enhancer;PID BioCarta;100079 |
Pathway | Wnt signaling pathway;PANTHER;P00057 |
Pathway | control of gene expression by vitamin d receptor;PID BioCarta;100007 |
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External Links |
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Links to Entrez Gene | 8289 |
Links to all GeneRIF Items | 8289 |
Links to iHOP | 8289 |
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Sequence Information |
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Nucleotide Sequence |
>8289 : length: 6858 atggccgcgcaggtcgcccccgccgccgccagcagcctgggcaacccgccgccgccgccg ccctcggagctgaagaaagccgagcagcagcagcgggaggaggcggggggcgaggcggcg gcggcggcagcggccgagcgcggggaaatgaaggcagccgccgggcaggaaagcgagggc cccgccgtggggccgccgcagccgctgggaaaggagctgcaggacggggccgagagcaat gggggtggcggcggcggcggagccggcagcggcggcgggcccggcgcggagccggacctg aagaactcgaacgggaacgcgggccctaggcccgccctgaacaataacctcacggagccg cccggcggcggcggtggcggcagcagcgatggggtgggggcgcctcctcactcagccgcg gccgccttgccgcccccagcctacggcttcgggcaaccctacggccggagcccgtctgcc gtcgccgccgccgcggccgccgtcttccaccaacaacatggcggacaacaaagccctggc ctggcagcgctgcagagcggcggcggcgggggcctggagccctacgcggggccccagcag aactctcacgaccacggcttccccaaccaccagtacaactcctactaccccaaccgcagc gcctaccccccgcccgccccggcctacgcgctgagctccccgagaggtggcactccgggc tccggcgcggcggcggctgccggctccaagccgcctccctcctccagcgcctccgcctcc tcgtcgtcttcgtccttcgctcagcagcgcttcggggccatggggggaggcggcccctcc gcggccggcgggggaactccccagcccaccgccacccccaccctcaaccaactgctcacg tcgcccagctcggcccggggctaccagggctaccccgggggcgactacagtggcgggccc caggacgggggcgccggcaagggcccggcggacatggcctcgcagtgttggggggctgcg gcggcggcagctgcggcggcggccgcctcgggaggggcccaacaaaggagccaccacgcg cccatgagccccgggagcagcggcggcggggggcagccgctcgcccggacccctcagcca tccagtccaatggatcagatgggcaagatgagacctcagccatatggcgggactaaccca tactcgcagcaacagggacctccgtcaggaccgcagcaaggacatgggtacccagggcag ccatacgggtcccagaccccgcagcggtacccgatgaccatgcagggccgggcgcagagt gccatgggcggcctctcttatacacagcagattcctccttatggacaacaaggccccagc gggtatggtcaacagggccagactccatattacaaccagcaaagtcctcaccctcagcag cagcagccaccctactcccagcaaccaccgtcccagacccctcatgcccaaccttcgtat cagcagcagccacagtctcaaccaccacagctccagtcctctcagcctccatactcccag cagccatcccagcctccacatcagcagtccccggctccatacccctcccagcagtcgacg acacagcagcacccccagagccagcccccctactcacagccacaggctcagtctccttac cagcagcagcaacctcagcagccagcaccctcgacgctctcccagcaggctgcgtatcct cagccccagtctcagcagtcccagcaaactgcctattcccagcagcgcttccctccaccg caggagctatctcaagattcatttgggtctcaggcatcctcagccccctcaatgacctcc agtaagggagggcaagaagatatgaacctgagccttcagtcaagaccctccagcttgcct gatctatctggttcaatagatgacctccccatggggacagaaggagctctgagtcctgga gtgagcacatcagggatttccagcagccaaggagagcagagtaatccagctcagtctcct ttctctcctcatacctcccctcacctgcctggcatccgaggcccttccccgtcccctgtt ggctctcccgccagtgttgctcagtctcgctcaggaccactctcgcctgctgcagtgcca ggcaaccagatgccacctcggccacccagtggccagtcggacagcatcatgcatccttcc atgaaccaatcaagcattgcccaagatcgaggttatatgcagaggaacccccagatgccc cagtacagttccccccagcccggctcagccttatctccgcgtcagccttccggaggacag atacacacaggcatgggctcctaccagcagaactccatggggagctatggtccccagggg ggtcagtatggcccacaaggtggctaccccaggcagccaaactataatgccttgcccaat gccaactaccccagtgcaggcatggctggaggcataaaccccatgggtgccggaggtcaa atgcatggacagcctggcatcccaccttatggcacactccctccagggaggatgagtcac gcctccatgggcaaccggccttatggccctaacatggccaatatgccacctcaggttggg tcagggatgtgtcccccaccagggggcatgaaccggaaaacccaagaaactgctgtcgcc atgcatgttgctgccaactctatccaaaacaggccgccaggctaccccaatatgaatcaa gggggcatgatgggaactggacctccttatggacaagggattaatagtatggctggcatg atcaaccctcagggacccccatattccatgggtggaaccatggccaacaattctgcaggg atggcagccagcccagagatgatgggccttggggatgtaaagttaactccagccaccaaa atgaacaacaaggcagatgggacacccaagacagaatccaaatccaagaaatccagttct tctactacaaccaatgagaagatcaccaagttgtatgagctgggtggtgagcctgagagg aagatgtgggtggaccgttatctggccttcactgaggagaaggccatgggcatgacaaat ctgcctgctgtgggtaggaaacctctggacctctatcgcctctatgtgtctgtgaaggag attggtggattgactcaggtcaacaagaacaaaaaatggcgggaacttgcaaccaacctc aatgtgggcacatcaagcagtgctgccagctccttgaaaaagcagtatatccagtgtctc tatgcctttgaatgcaagattgaacggggagaagaccctcccccagacatctttgcagct gctgattccaagaagtcccagcccaagatccagcctccctctcctgcgggatcaggatct atgcaggggccccagactccccagtcaaccagcagttccatggcagaaggaggagactta aagccaccaactccagcatccacaccacacagtcagatccccccattgccaggcatgagc aggagcaattcagttgggatccaggatgcctttaatgatggaagtgactccacattccag aagcggaattccatgactccaaaccctgggtatcagcccagtatgaatacctctgacatg atggggcgcatgtcctatgagccaaataaggatccttatggcagcatgaggaaagctcca gggagtgatcccttcatgtcctcagggcagggccccaacggcgggatgggtgacccctac agtcgtgctgccggccctgggctaggaaatgtggcgatgggaccacgacagcactatccc tatggaggtccttatgacagagtgaggacggagcctggaatagggcctgagggaaacatg agcactggggccccacagccgaatctcatgccttccaacccagactcggggatgtattct cctagccgctaccccccgcagcagcagcagcagcagcagcaacgacatgattcctatggc aatcagttctccacccaaggcaccccttctggcagccccttccccagccagcagactaca atgtatcaacagcaacagcagaattacaagcggccaatggatggcacatatggccctcct gccaagcggcacgaaggggagatgtacagcgtgccatacagcactgggcaggggcagcct cagcagcagcagttgcccccagcccagccccagcctgccagccagcaacaagctgcccag ccttcccctcagcaagatgtatacaaccagtatggcaatgcctatcctgccactgccaca gctgctactgagcgccgaccagcaggcggcccccagaaccaatttccattccagtttggc cgagaccgtgtctctgcaccccctggcaccaatgcccagcaaaacatgccaccacaaatg atgggcggccccatacaggcatcagctgaggttgctcagcaaggcaccatgtggcagggg cgtaatgacatgacctataattatgccaacaggcagagcacgggctctgccccccagggc cccgcctatcatggcgtgaaccgaacagatgaaatgctgcacacagatcagagggccaac cacgaaggctcgtggccttcccatggcacacgccagcccccatatggtccctctgcccct gtgccccccatgacaaggccccctccatctaactaccagcccccaccaagcatgcagaat cacattcctcaggtatccagccctgctcccctgccccggccaatggagaaccgcacctct cctagcaagtctccattcctgcactctgggatgaaaatgcagaaggcaggtcccccagta cctgcctcgcacatagcacctgcccctgtgcagccccccatgattcggcgggatatcacc ttcccacctggctctgttgaagccacacagcctgtgttgaagcagaggaggcggctcaca atgaaagacattggaaccccggaggcatggcgggtaatgatgtccctcaagtctggtctc ctggcagagagcacatgggcattagataccatcaacatcctgctgtatgatgacaacagc atcatgaccttcaacctcagtcagctcccagggttgctagagctccttgtagaatatttc cgacgatgcctgattgagatctttggcattttaaaggagtatgaggtgggtgacccagga cagagaacgctactggatcctgggaggttcagcaaggtgtctagtccagctcccatggag ggtggggaagaagaagaagaacttctaggtcctaaactagaagaggaagaagaagaggaa gtagttgaaaatgatgaggagatagccttttcaggcaaggacaagccagcttcagagaat agtgaggagaagctgatcagtaagtttgacaagcttccagtaaagatcgtacagaagaat gatccatttgtggtggactgctcagataagcttgggcgtgtgcaggagtttgacagtggc ctgctgcactggcggattggtgggggggacaccactgagcatatccagacccacttcgag agcaagacagagctgctgccttcccggcctcacgcaccctgcccaccagcccctcggaag catgtgacaacagcagagggtacaccagggacaacagaccaggaggggcccccacctgat ggacctccagaaaaacggatcacagccactatggatgacatgttgtctactcggtctagc accttgaccgaggatggagctaagagttcagaggccatcaaggagagcagcaagtttcca tttggcattagcccagcacagagccaccggaacatcaagatcctagaggacgaaccccac agtaaggatgagaccccactgtgtacccttctggactggcaggattctcttgccaagcgc tgcgtctgtgtgtccaataccattcgaagcctgtcatttgtgccaggcaatgactttgag atgtccaaacacccagggctgctgctcatcctgggcaagctgatcctgctgcaccacaag cacccagaacggaagcaggcaccactaacttatgaaaaggaggaggaacaggaccaaggg gtgagctgcaacaaagtggagtggtggtgggactgcttggagatgctccgggaaaacacc ttggttacactcgccaacatctcggggcagttggacctatctccataccccgagagcatt tgcctgcctgtcctggacggactcctacactgggcagtttgcccttcagctgaagcccag gaccccttttccaccctgggccccaatgccgtcctttccccgcagagactggtcttggaa accctcagcaaactcagcatccaggacaacaatgtggacctgattctggccacacccccc ttcagccgcctggagaagttgtatagcactatggtgcgcttcctcagtgaccgaaagaac ccggtgtgccgggagatggctgtggtactgctggccaacctggctcagggggacagcctg gcagctcgtgccattgcagtgcagaagggcagtatcggcaacctcctgggcttcctagag gacagccttgccgccacacagttccagcagagccaggccagcctcctccacatgcagaac ccaccctttgagccaactagtgtggacatgatgcggcgggctgcccgcgcgctgcttgcc ttggccaaggtggacgagaaccactcagagtttactctgtacgaatcacggctgttggac atctcggtatcaccgttgatgaactcattggtttcacaagtcatttgtgatgtactgttt ttgattggccagtcatga |
Protein Sequence |
>8289 : length: 2285 MAAQVAPAAASSLGNPPPPPPSELKKAEQQQREEAGGEAAAAAAAERGEMKAAAGQESEG PAVGPPQPLGKELQDGAESNGGGGGGGAGSGGGPGAEPDLKNSNGNAGPRPALNNNLTEP PGGGGGGSSDGVGAPPHSAAAALPPPAYGFGQPYGRSPSAVAAAAAAVFHQQHGGQQSPG LAALQSGGGGGLEPYAGPQQNSHDHGFPNHQYNSYYPNRSAYPPPAPAYALSSPRGGTPG SGAAAAAGSKPPPSSSASASSSSSSFAQQRFGAMGGGGPSAAGGGTPQPTATPTLNQLLT SPSSARGYQGYPGGDYSGGPQDGGAGKGPADMASQCWGAAAAAAAAAAASGGAQQRSHHA PMSPGSSGGGGQPLARTPQPSSPMDQMGKMRPQPYGGTNPYSQQQGPPSGPQQGHGYPGQ PYGSQTPQRYPMTMQGRAQSAMGGLSYTQQIPPYGQQGPSGYGQQGQTPYYNQQSPHPQQ QQPPYSQQPPSQTPHAQPSYQQQPQSQPPQLQSSQPPYSQQPSQPPHQQSPAPYPSQQST TQQHPQSQPPYSQPQAQSPYQQQQPQQPAPSTLSQQAAYPQPQSQQSQQTAYSQQRFPPP QELSQDSFGSQASSAPSMTSSKGGQEDMNLSLQSRPSSLPDLSGSIDDLPMGTEGALSPG VSTSGISSSQGEQSNPAQSPFSPHTSPHLPGIRGPSPSPVGSPASVAQSRSGPLSPAAVP GNQMPPRPPSGQSDSIMHPSMNQSSIAQDRGYMQRNPQMPQYSSPQPGSALSPRQPSGGQ IHTGMGSYQQNSMGSYGPQGGQYGPQGGYPRQPNYNALPNANYPSAGMAGGINPMGAGGQ MHGQPGIPPYGTLPPGRMSHASMGNRPYGPNMANMPPQVGSGMCPPPGGMNRKTQETAVA MHVAANSIQNRPPGYPNMNQGGMMGTGPPYGQGINSMAGMINPQGPPYSMGGTMANNSAG MAASPEMMGLGDVKLTPATKMNNKADGTPKTESKSKKSSSSTTTNEKITKLYELGGEPER KMWVDRYLAFTEEKAMGMTNLPAVGRKPLDLYRLYVSVKEIGGLTQVNKNKKWRELATNL NVGTSSSAASSLKKQYIQCLYAFECKIERGEDPPPDIFAAADSKKSQPKIQPPSPAGSGS MQGPQTPQSTSSSMAEGGDLKPPTPASTPHSQIPPLPGMSRSNSVGIQDAFNDGSDSTFQ KRNSMTPNPGYQPSMNTSDMMGRMSYEPNKDPYGSMRKAPGSDPFMSSGQGPNGGMGDPY SRAAGPGLGNVAMGPRQHYPYGGPYDRVRTEPGIGPEGNMSTGAPQPNLMPSNPDSGMYS PSRYPPQQQQQQQQRHDSYGNQFSTQGTPSGSPFPSQQTTMYQQQQQNYKRPMDGTYGPP AKRHEGEMYSVPYSTGQGQPQQQQLPPAQPQPASQQQAAQPSPQQDVYNQYGNAYPATAT AATERRPAGGPQNQFPFQFGRDRVSAPPGTNAQQNMPPQMMGGPIQASAEVAQQGTMWQG RNDMTYNYANRQSTGSAPQGPAYHGVNRTDEMLHTDQRANHEGSWPSHGTRQPPYGPSAP VPPMTRPPPSNYQPPPSMQNHIPQVSSPAPLPRPMENRTSPSKSPFLHSGMKMQKAGPPV PASHIAPAPVQPPMIRRDITFPPGSVEATQPVLKQRRRLTMKDIGTPEAWRVMMSLKSGL LAESTWALDTINILLYDDNSIMTFNLSQLPGLLELLVEYFRRCLIEIFGILKEYEVGDPG QRTLLDPGRFSKVSSPAPMEGGEEEEELLGPKLEEEEEEEVVENDEEIAFSGKDKPASEN SEEKLISKFDKLPVKIVQKNDPFVVDCSDKLGRVQEFDSGLLHWRIGGGDTTEHIQTHFE SKTELLPSRPHAPCPPAPRKHVTTAEGTPGTTDQEGPPPDGPPEKRITATMDDMLSTRSS TLTEDGAKSSEAIKESSKFPFGISPAQSHRNIKILEDEPHSKDETPLCTLLDWQDSLAKR CVCVSNTIRSLSFVPGNDFEMSKHPGLLLILGKLILLHHKHPERKQAPLTYEKEEEQDQG VSCNKVEWWWDCLEMLRENTLVTLANISGQLDLSPYPESICLPVLDGLLHWAVCPSAEAQ DPFSTLGPNAVLSPQRLVLETLSKLSIQDNNVDLILATPPFSRLEKLYSTMVRFLSDRKN PVCREMAVVLLANLAQGDSLAARAIAVQKGSIGNLLGFLEDSLAATQFQQSQASLLHMQN PPFEPTSVDMMRRAARALLALAKVDENHSEFTLYESRLLDISVSPLMNSLVSQVICDVLF LIGQS |