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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 8821 |
Name | INPP4B |
Synonym | -;inositol polyphosphate-4-phosphatase, type II, 105kDa;INPP4B;inositol polyphosphate-4-phosphatase, type II, 105kDa |
Definition | inositol polyphosphate 4-phosphatase II; 4-phosphatase II|inositol polyphosphate 4-phosphatase type II|type II inositol-3,4-bisphosphate 4-phosphatase |
Position | 4q31.21 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 2 PubMed records as below. |
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Evidence Status |
Description |
reviewed | INPP4B functions as a tumor suppressor by negatively regulating normal and malignant mammary epithelial cell proliferation through regulation of the PI3K/Akt signaling pathway. |
potential | INPP4B functions as a tumor suppressor by negatively regulating normal and malignant mammary epithelial cell proliferation through regulation of the PI3K/Akt signaling pathway. |
potential | "INPP4B has been identified as a tumor suppressor. Loss of heterozygosity (LOH) is found at the INPP4B locus in basal-like breast cancers, as well as in a significant fraction of ovarian cancers." |
| More detail of all 2 literatures about INPP4B | |
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Pathways and Diseases |
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Pathway | 3-phosphoinositide degradation;BioCyc;PWY-6368 |
Pathway | Phosphatidylinositol signaling system;KEGG PATHWAY;hsa04070 |
Pathway | Inositol phosphate metabolism;KEGG PATHWAY;hsa00562 |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
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External Links |
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Links to Entrez Gene | 8821 |
Links to all GeneRIF Items | 8821 |
Links to iHOP | 8821 |
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Sequence Information |
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Nucleotide Sequence |
>8821 : length: 2775 atggaaattaaagaggaaggggcatcagaagaagggcagcactttcttcctacagcccag gccaatgatcccggggactgtcagttcacaagtatccagaagactccaaatgaaccgcag ttggaattcatccttgcatgcaaggatctcgtggctcctgtccgtgatcgtaaactgaat acactggtgcagatctccgtaatccaccccgtggagcagagtctgacaagatactccagc accgaaattgtggagggaacaagggacccactgtttttgactggtgtcacattcccatct gagtatcccatctatgaggagaccaaaataaaactaacagtctatgatgtcaaggataag tctcatgacaccgttcgaaccagtgtcctaccagaacataaggatcccccgccagaagtt gggcgaagtttcttgggctatgccagttttaaagtgggagagctgctgaagtcaaaggag caattgctggtcctgagcctgagaacttcagatggtggcaaagtggttggcaccatagaa gtcagtgtcgtgaagatgggggagattgaggatggggaagccgaccacatcaccacagat gtacagggacaaaagtgtgccctggtatgtgaatgtacagccccggaaagtgtgagcgga aaagataacttaccttttttgaattcagtgttaaagaacccagtatgtaaattatataga tttcccacatctgacaataagtggatgcgaattcgagagcagatgtcagagagcattctt tcctttcatattcctaaggaattgatttcccttcacattaaagaagatttgtgcagaaac caggagataaaagaacttggtgagctttctccacattgggacaatctgcgaaaaaatgtc cttactcactgtgatcaaatggtgaatatgtaccaagacattctgacagaacttagcaag gaaacagggtcctctttcaaatcaagcagcagcaaaggagagaaaacattagaatttgtt ccaataaatctacatctgcaaagaatgcaggtacacagccctcacttgaaagatgctctc tacgatgtcatcactgtgggagccccagctgcccattttcagggatttaagaatggtggt cttcggaagctactccatagatttgaaacagaaagaagaaataccggataccagtttatt tactattcacctgaaaacacagccaaagcaaaggaagttctcagcaacatcaatcaacta caacctcttatagcaacccatgcagacctactgcttaattctgcaagccagcattctcca gacagcttgaagaattctttaaagatgctttcagaaaaaacagagctttttgtacatgcc ttcaaggatcaacttgtcaggagtgctcttttagcactctacactgcaaggccaggaggc attcttaagaagccaccctctcctaagagcagcacagaggagagcagtccccaagaccaa cccccagtgatgagagggcaggactccataccacatcattcagactatgatgaggaagag tgggacagggtgtgggccaatgtggggaagagcctgaactgcattattgctatggtggac aaactgattgaaagagatggtggcagtgaaggcagtggcggcaacaatgatggagaaaag gaaccttcattaacagatgccattccctctcacccaagagaggactggtatgaacagttg tatcccctcatccttaccctgaaggactgcatgggagaagtggtgaaccgagccaagcag tccctgacatttgtgctccttcaggaacttgcgtacagcttgccccagtgtctgatgctg acgctaagaagagacatcgtcttcagccaagcacttgctggattggtttgtggttttatc atcaaattacagacaagtctgtatgacccaggcttcctacagcagcttcacacagtgggg ttgatagtacaatatgaaggactgctaagtacatacagcgatgaaattggaatgctagag gacatggccgttggcatttccgatttaaagaaagttgcatttaaaataattgaagccaaa tccaatgatgtgttgccagttataacaggaagacgagaacattacgtggtagaggtcaag cttccagccagaatgtttgagtcactacctctacagattaaagaaggacagttgcttcat gtgtatccagtactttttaatgttggaatcaatgaacagcaaactctggctgaaaggttt ggagatgtctctttgcaagaaagtattaatcaggaaaacttcgaacttctacaagaatat tacaagatatttatggaaaagatgcctcctgattatatttcacattttcaggaacaaaat gatttaaaagcattgctagaaaatctccttcaaaatatccaatccaaaaaaagaaagaat gtagaaattatgtggctggctgcaacgatttgccgcaaactgaatggtattcgtttcacc tgttgtaaaagtgccaaagacaggacatcgatgtcagtgacacttgaacaatgctcaatc ttgagagatgagcaccagttacacaaggacttctttatccgagcgctggattgcatgaga agagaaggatgccgcatagagaatgtactgaagaatatcaaatgcagaaagtatgctttc aacatgctacagctgatggctttccccaagtactacagacctccagaggggacttatgga aaagctgacacctaa |
Protein Sequence |
>8821 : length: 924 MEIKEEGASEEGQHFLPTAQANDPGDCQFTSIQKTPNEPQLEFILACKDLVAPVRDRKLN TLVQISVIHPVEQSLTRYSSTEIVEGTRDPLFLTGVTFPSEYPIYEETKIKLTVYDVKDK SHDTVRTSVLPEHKDPPPEVGRSFLGYASFKVGELLKSKEQLLVLSLRTSDGGKVVGTIE VSVVKMGEIEDGEADHITTDVQGQKCALVCECTAPESVSGKDNLPFLNSVLKNPVCKLYR FPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQEIKELGELSPHWDNLRKNV LTHCDQMVNMYQDILTELSKETGSSFKSSSSKGEKTLEFVPINLHLQRMQVHSPHLKDAL YDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFIYYSPENTAKAKEVLSNINQL QPLIATHADLLLNSASQHSPDSLKNSLKMLSEKTELFVHAFKDQLVRSALLALYTARPGG ILKKPPSPKSSTEESSPQDQPPVMRGQDSIPHHSDYDEEEWDRVWANVGKSLNCIIAMVD KLIERDGGSEGSGGNNDGEKEPSLTDAIPSHPREDWYEQLYPLILTLKDCMGEVVNRAKQ SLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLQTSLYDPGFLQQLHTVG LIVQYEGLLSTYSDEIGMLEDMAVGISDLKKVAFKIIEAKSNDVLPVITGRREHYVVEVK LPARMFESLPLQIKEGQLLHVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELLQEY YKIFMEKMPPDYISHFQEQNDLKALLENLLQNIQSKKRKNVEIMWLAATICRKLNGIRFT CCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRKYAF NMLQLMAFPKYYRPPEGTYGKADT |