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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 9447 |
Name | AIM2 |
Synonym | PYHIN4;absent in melanoma 2;AIM2;absent in melanoma 2 |
Definition | interferon-inducible protein AIM2 |
Position | 1q22 |
Gene Type | protein-coding |
Source | Count: 3; TAG,UniProt,Generif |
Literature support | Count: 3 PubMed records as below. |
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Evidence Status |
Description |
potential | The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers. |
potential | "Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2." |
reviewed | The importance of HIN-200 proteins in disease now is beginning to be understood as they appear to be involved in autoimmunity and may act as tumor suppressor proteins. |
| More detail of all 3 literatures about AIM2 | |
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Pathways and Diseases |
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Pathway | Cytosolic DNA-sensing pathway;KEGG PATHWAY;hsa04623 |
Disease | Colon cancer;FunDO |
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External Links |
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Links to Entrez Gene | 9447 |
Links to all GeneRIF Items | 9447 |
Links to iHOP | 9447 |
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Sequence Information |
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Nucleotide Sequence |
>9447 : length: 1032 atggagagtaaatacaaggagatactcttgctaacaggcctggataacatcactgatgag gaactggataggtttaagttctttctttcagacgagtttaatattgccacaggcaaacta catactgcaaacagaatacaagtagctaccttgatgattcaaaatgctggggcggtgtct gcagtgatgaagaccattcgtatttttcagaagttgaattatatgcttttggcaaaacgt cttcaggaggagaaggagaaagttgataagcaatacaaatcggtaacaaaaccaaagcca ctaagtcaagctgaaatgagtcctgctgcatctgcagccatcagaaatgatgtcgcaaag caacgtgctgcaccaaaagtctctcctcatgttaagcctgaacagaaacagatggtggcc cagcaggaatctatcagagaagggtttcagaagcgctgtttgccagttatggtactgaaa gcaaagaagcccttcacgtttgagacccaagaaggcaagcaggagatgtttcatgctaca gtggctacagaaaaggaattcttctttgtaaaagtttttaatacactgctgaaagataaa ttcattccaaagagaataattataatagcaagatattatcggcacagtggtttcttagag gtaaatagcgcctcacgtgtgttagatgctgaatctgaccaaaaggttaatgtcccgctg aacattatcagaaaagctggtgaaaccccgaagatcaacacgcttcaaactcagcccctt ggaacaattgtgaatggtttgtttgtagtccagaaggtaacagaaaagaagaaaaacata ttatttgacctaagtgacaacactgggaaaatggaagtactgggggttagaaacgaggac acaatgaaatgtaaggaaggagataaggttcgacttacattcttcacactgtcaaaaaat ggagaaaaactacagctgacatctggagttcatagcaccataaaggttattaaggccaaa aaaaaaacatag |
Protein Sequence |
>9447 : length: 343 MESKYKEILLLTGLDNITDEELDRFKFFLSDEFNIATGKLHTANRIQVATLMIQNAGAVS AVMKTIRIFQKLNYMLLAKRLQEEKEKVDKQYKSVTKPKPLSQAEMSPAASAAIRNDVAK QRAAPKVSPHVKPEQKQMVAQQESIREGFQKRCLPVMVLKAKKPFTFETQEGKQEMFHAT VATEKEFFFVKVFNTLLKDKFIPKRIIIIARYYRHSGFLEVNSASRVLDAESDQKVNVPL NIIRKAGETPKINTLQTQPLGTIVNGLFVVQKVTEKKKNILFDLSDNTGKMEVLGVRNED TMKCKEGDKVRLTFFTLSKNGEKLQLTSGVHSTIKVIKAKKKT |