Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

1869

Name

E2F1

Synonymous

E2F-1|RBAP1|RBBP3|RBP3;E2F transcription factor 1;E2F1;E2F transcription factor 1

Definition

PBR3|PRB-binding protein E2F-1|RBAP-1|RBBP-3|retinoblastoma-associated protein 1|retinoblastoma-binding protein 3|transcription factor E2F1

Position

20q11.2

Gene Type

protein-coding

Gene Interactions:

Physical Interaction
Metabolic Interaction
Signaling Interaction

Physical Interaction

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Interaction Type

Interactor

Data Source

interacts with

 NDNL2BIOGRID; PUBMED:14593116;

interacts with

 MDM2BIOGRID; PUBMED:16170383;

interacts with

 MDM4BIOGRID; PUBMED:12532331;

interacts with

 MGABIOGRID; PUBMED:12748276;

interacts with

 MCPH1BIOGRID; PUBMED:18660752;

interacts with

 TFDP2BIOGRID; PUBMED:7739537;

interacts with

 TP53BP1BIOGRID; PUBMED:8896460;

interacts with

 TBPBIOGRID; PUBMED:17111193;

interacts with

 TRIM28BIOGRID; PUBMED:17704056;

interacts with

 TOPBP1BIOGRID; PUBMED:12697828;

interacts with

 TOPBP1BIOGRID; PUBMED:14576433;

interacts with

 TOPBP1BIOGRID; PUBMED:20413589;

interacts with

 TEAD3BIOGRID; PUBMED:12748276;

interacts with

 TFDP1BIOGRID; PUBMED:19015639;

interacts with

 TFDP1BIOGRID; PUBMED:7739537;

interacts with

 TFDP1BIOGRID; PUBMED:7892279;

interacts with

 TFDP1BIOGRID; PUBMED:8405995;

interacts with

 TFDP1BIOGRID; PUBMED:9780002;

interacts with

 GTF2H1BIOGRID; PUBMED:10428966;

interacts with

 NPDC1BIOGRID; PUBMED:11042687;

interacts with

 NDNBIOGRID; PUBMED:14593116;

interacts with

 NDNBIOGRID; PUBMED:9422723;

interacts with

 NCOA6BIOGRID; PUBMED:14638867;

interacts with

 NRIP1BIOGRID; PUBMED:20410059;

interacts with

 MYBL2BIOGRID; PUBMED:12748276;

interacts with

 NFKB1BIOGRID; PUBMED:9368006;

interacts with

 LEF1BIOGRID; PUBMED:17980157;

interacts with

 KDM1ABIOGRID; PUBMED:20603083;

interacts with

 KLF6BIOGRID; PUBMED:18521079;

interacts with

 CREBBPBIOGRID; PUBMED:12748276;

interacts with

 CDK2BIOGRID; PUBMED:7969176;

interacts with

 ATMBIOGRID; PUBMED:11459832;

interacts with

 ASH2LBIOGRID; PUBMED:17612494;

interacts with

 ARID3ABIOGRID; PUBMED:9780002;

interacts with

 BRD2BIOGRID; PUBMED:10965846;

interacts with

 BRD2BIOGRID; PUBMED:17111193;

interacts with

 ATAD2BIOGRID; PUBMED:20855524;

interacts with

 ATRBIOGRID; PUBMED:11459832;

interacts with

 E2F4BIOGRID; PUBMED:16357170;

interacts with

 GSK3BBIOGRID; PUBMED:18367454;

interacts with

 HDAC1BIOGRID; PUBMED:10734134;

interacts with

 HDAC1BIOGRID; PUBMED:17980157;

interacts with

 HCFC1BIOGRID; PUBMED:17612494;

interacts with

 CDK7BIOGRID; PUBMED:10428966;

interacts with

 FHL2BIOGRID; PUBMED:12411495;

interacts with

 DNMT1BIOGRID; PUBMED:10888886;

interacts with

 CCNA1BIOGRID; PUBMED:10022926;

interacts with

 CCNA1BIOGRID; PUBMED:16774918;

interacts with

 Nfkb1BIOGRID; PUBMED:9368006;

interacts with

 CUL1BIOGRID; PUBMED:10559858;

interacts with

 CUL1BIOGRID; PUBMED:11245432;

interacts with

 CDKN1ABIOGRID; PUBMED:15964998;

interacts with

 PKIBBIOGRID; PUBMED:12748276;

interacts with

 KAT2BBIOGRID; PUBMED:19188449;

interacts with

 KAT5BIOGRID; PUBMED:15121871;

interacts with

 KAT2ABIOGRID; PUBMED:11418595;

interacts with

 RNF144ABIOGRID; PUBMED:12411495;

interacts with

 RING1BIOGRID; PUBMED:11583618;

interacts with

 RB1BIOGRID; PUBMED:10869426;

interacts with

 RB1BIOGRID; PUBMED:11470869;

interacts with

 RB1BIOGRID; PUBMED:11839806;

interacts with

 RB1BIOGRID; PUBMED:12397079;

interacts with

 RB1BIOGRID; PUBMED:12963846;

interacts with

 RB1BIOGRID; PUBMED:15485920;

interacts with

 RB1BIOGRID; PUBMED:15670817;

interacts with

 RB1BIOGRID; PUBMED:16766265;

interacts with

 RB1BIOGRID; PUBMED:18216119;

interacts with

 RB1BIOGRID; PUBMED:7739537;

interacts with

 RB1BIOGRID; PUBMED:8230483;

interacts with

 RB1BIOGRID; PUBMED:8896460;

interacts with

 RB1BIOGRID; PUBMED:9422723;

interacts with

 RBX1BIOGRID; PUBMED:11245432;

interacts with

 RBL1BIOGRID; PUBMED:8230483;

interacts with

 RBBP4BIOGRID; PUBMED:10734134;

interacts with

 PURABIOGRID; PUBMED:10597240;

interacts with

 CCNA2BIOGRID; PUBMED:7969176;

interacts with

 YWHAQBIOGRID; PUBMED:15494392;

interacts with

 PHBBIOGRID; PUBMED:10523633;

interacts with

 PHBBIOGRID; PUBMED:12065415;

interacts with

 PHBBIOGRID; PUBMED:14500729;

interacts with

 PHBBIOGRID; PUBMED:14637159;

interacts with

 PHBBIOGRID; PUBMED:15141164;

interacts with

 PRDM2BIOGRID; PUBMED:9223517;

interacts with

 Sp1BIOGRID; PUBMED:8657141;

interacts with

 SP2BIOGRID; PUBMED:10547281;

interacts with

 SPIBBIOGRID; PUBMED:12748276;

interacts with

 SKP2BIOGRID; PUBMED:10559858;

interacts with

 SKP2BIOGRID; PUBMED:12097298;

interacts with

 SKP2BIOGRID; PUBMED:16170383;

interacts with

 SP3BIOGRID; PUBMED:10547281;

interacts with

 SP1BIOGRID; PUBMED:10409740;

interacts with

 SP1BIOGRID; PUBMED:10547281;

interacts with

 SP1BIOGRID; PUBMED:8657141;

interacts with

 SP1BIOGRID; PUBMED:8657142;

interacts with

 SP4BIOGRID; PUBMED:10547281;

interacts with

 TRRAPBIOGRID; PUBMED:11418595;

interacts with

 TRRAPBIOGRID; PUBMED:9708738;

interacts with

 SETD7BIOGRID; PUBMED:20603083;

interacts with

 SIRT1BIOGRID; PUBMED:19188449;

interacts with

 CDT1BIOGRID; PUBMED:18162579;

interacts with

 MDM2HPRD; PUBMED:16374512;

interacts with

 MNAT1HPRD; PUBMED:10428966;

interacts with

 MDM4HPRD; PUBMED:12532331;

interacts with

 TFDP2HPRD; PUBMED:8755520;

interacts with

 TP53BP1HPRD; PUBMED:8896460;

interacts with

 TFDP1HPRD; PUBMED:16360038;

interacts with

 TFDP1HPRD; PUBMED:8816502;

interacts with

 TFDP1HPRD; PUBMED:8846921;

interacts with

 GTF2H1HPRD; PUBMED:10428966;

interacts with

 NCOA3HPRD; PUBMED:15169882;

interacts with

 NPDC1HPRD; PUBMED:9181131;

interacts with

 NDNHPRD; PUBMED:14593116;

interacts with

 NCOA6HPRD; PUBMED:14638867;

interacts with

 NFKB1HPRD; PUBMED:9368006;

interacts with

 CREBBPHPRD; PUBMED:8932363;

interacts with

 CDK2HPRD; PUBMED:7969176;

interacts with

 CDK2HPRD; PUBMED:9199321;

interacts with

 ARID1BHPRD; PUBMED:17255939;

interacts with

 ATMHPRD; PUBMED:11459832;

interacts with

 ARID3AHPRD; PUBMED:9780002;

interacts with

 BRD2HPRD; PUBMED:10965846;

interacts with

 ATRHPRD; PUBMED:11459832;

interacts with

 E2F4HPRD; PUBMED:17255939;

interacts with

 GSK3BHPRD; PUBMED:18367454;

interacts with

 HDAC3HPRD; PUBMED:17255939;

interacts with

 CDK3HPRD; PUBMED:11733001;

interacts with

 CDK3HPRD; PUBMED:8846921;

interacts with

 CDK7HPRD; PUBMED:10428966;

interacts with

 E2F6HPRD; PUBMED:9689056;

interacts with

 DNMT1HPRD; PUBMED:10888886;

interacts with

 E2F5HPRD; PUBMED:17255939;

interacts with

 CEBPEHPRD; PUBMED:12947005;

interacts with

 CDKN2AHPRD; PUBMED:11314038;

interacts with

 CUL1HPRD; PUBMED:10559858;

interacts with

 DDB2HPRD; PUBMED:9418871;

interacts with

 CTDP1HPRD; PUBMED:14576433;

interacts with

 RB1HPRD; PUBMED:1388726;

interacts with

 RB1HPRD; PUBMED:16374512;

interacts with

 RB1HPRD; PUBMED:16616919;

interacts with

 RB1HPRD; PUBMED:9501179;

interacts with

 RBL1HPRD; PUBMED:9501179;

interacts with

 PURAHPRD; PUBMED:10597240;

interacts with

 CCNA2HPRD; PUBMED:12501191;

interacts with

 CCNA2HPRD; PUBMED:7969176;

interacts with

 CCNA2HPRD; PUBMED:9199321;

interacts with

 PRMT2HPRD; PUBMED:16616919;

interacts with

 PHBHPRD; PUBMED:10523633;

interacts with

 SP2HPRD; PUBMED:10547281;

interacts with

 SKP2HPRD; PUBMED:10559858;

interacts with

 STAT3HPRD; PUBMED:17255939;

interacts with

 SP3HPRD; PUBMED:10547281;

interacts with

 SERTAD2HPRD; PUBMED:11331592;

interacts with

 SP1HPRD; PUBMED:10547281;

interacts with

 SP4HPRD; PUBMED:10547281;

interacts with

 TRIM36HPRD; PUBMED:16360038;

interacts with

 TRRAPHPRD; PUBMED:9708738;

interacts with

 PARP1HPRD; PUBMED:14627987;

interacts with

 CHEK2HPRD; PUBMED:12717439;

interacts with

 RB1INTACT; PUBMED:20871633;

interacts with

 MCPH1MINT; PUBMED:18660752;

interacts with

 TOPBP1MINT; PUBMED:14576432;

interacts with

 TOPBP1MINT; PUBMED:17006541;

interacts with

 BTG3MINT; PUBMED:17690688;

interacts with

 RB1MINT; PUBMED:11713253;

interacts with

 RB1MINT; PUBMED:16374512;

interacts with

 RB1MINT; PUBMED:17380128;

Metabolic Interaction

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Interaction Type

Interactor

Data Source

metabolic catalysis

 TFDP2NCI_NATURE; PUBMED:11418595;

metabolic catalysis

 TFDP2NCI_NATURE; PUBMED:7958837;PUBMED:7958836;PUBMED:10766737;PUBMED:9192872;PUBMED:9724731;

metabolic catalysis

 E2F4NCI_NATURE; PUBMED:11418595;

metabolic catalysis

 E2F4NCI_NATURE; PUBMED:7958837;PUBMED:7958836;PUBMED:10766737;PUBMED:9192872;PUBMED:9724731;

metabolic catalysis

 HDAC1NCI_NATURE; PUBMED:7958837;PUBMED:7958836;PUBMED:10766737;PUBMED:9192872;PUBMED:9724731;

metabolic catalysis

 HES1NCI_NATURE; PUBMED:15467735;

metabolic catalysis

 E2F6NCI_NATURE; PUBMED:7958837;PUBMED:7958836;PUBMED:9689056;

metabolic catalysis

 E2F1NCI_NATURE; PUBMED:7958837;PUBMED:16179649;PUBMED:7958836;PUBMED:14633988;

metabolic catalysis

 E2F1NCI_NATURE; PUBMED:7958837;PUBMED:7958836;PUBMED:10766737;PUBMED:9192872;PUBMED:9724731;

metabolic catalysis

 E2F1NCI_NATURE; PUBMED:7958837;PUBMED:7958836;PUBMED:16892051;

metabolic catalysis

 E2F1NCI_NATURE; PUBMED:7958837;PUBMED:7958836;PUBMED:9689056;

metabolic catalysis

 KAT2ANCI_NATURE; PUBMED:11418595;

metabolic catalysis

 SP1NCI_NATURE; PUBMED:7958837;PUBMED:16179649;PUBMED:7958836;PUBMED:14633988;

metabolic catalysis

 SP1NCI_NATURE; PUBMED:7958837;PUBMED:7958836;PUBMED:10766737;PUBMED:9192872;PUBMED:9724731;

metabolic catalysis

 SP1NCI_NATURE; PUBMED:7958837;PUBMED:7958836;PUBMED:16892051;

metabolic catalysis

 SP1NCI_NATURE; PUBMED:7958837;PUBMED:7958836;PUBMED:9689056;

metabolic catalysis

 SIRT1NCI_NATURE; PUBMED:7958837;PUBMED:7958836;PUBMED:16892051;

metabolic catalysis

 LIN37REACTOME; PUBMED:17531812;

metabolic catalysis

 LIN54REACTOME; PUBMED:17531812;

metabolic catalysis

 LIN52REACTOME; PUBMED:17531812;

metabolic catalysis

 LIN9REACTOME; PUBMED:17531812;

metabolic catalysis

 E2F4REACTOME; PUBMED:11959842;

metabolic catalysis

 HDAC1REACTOME; PUBMED:11959842;

metabolic catalysis

 RBL1REACTOME; PUBMED:11959842;

metabolic catalysis

 RBBP4REACTOME; PUBMED:17531812;

metabolic catalysis

 RBL2REACTOME; PUBMED:11959842;

metabolic catalysis

 RBL2REACTOME; PUBMED:17531812;

Signaling Interaction

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Interaction Type

Interactor

Data Source

reacts with

 NDNL2NCI_NATURE; PUBMED:14593116;

state change

 TRIM28NCI_NATURE; PUBMED:17704056;

reacts with

 TOPBP1NCI_NATURE; PUBMED:12697828;

reacts with

 NGFRNCI_NATURE; PUBMED:12414813;PUBMED:14593116;

reacts with

 NGFRNCI_NATURE; PUBMED:14593116;

reacts with

 NDNNCI_NATURE; PUBMED:12414813;PUBMED:14593116;

reacts with

 NGFNCI_NATURE; PUBMED:12414813;PUBMED:14593116;

reacts with

 NGFNCI_NATURE; PUBMED:14593116;

state change

 RPS6KB1NCI_NATURE; PUBMED:10373522;

state change

 ATMNCI_NATURE; PUBMED:11459832;

reacts with

 HDAC1NCI_NATURE; PUBMED:17704056;

reacts with

 E2F1NCI_NATURE; PUBMED:11459832;

reacts with

 E2F1NCI_NATURE; PUBMED:12414813;PUBMED:14593116;

reacts with

 E2F1NCI_NATURE; PUBMED:12697828;

reacts with

 E2F1NCI_NATURE; PUBMED:12766778;

reacts with

 E2F1NCI_NATURE; PUBMED:14593116;

reacts with

 E2F1NCI_NATURE; PUBMED:17704056;

reacts with

 KAT2BNCI_NATURE; PUBMED:12766778;

reacts with

 SORT1NCI_NATURE; PUBMED:12414813;PUBMED:14593116;

reacts with

 SORT1NCI_NATURE; PUBMED:14593116;

reacts with

 CDC25AREACTOME; PUBMED:17531812;

reacts with

 TOP2AREACTOME; PUBMED:17531812;

reacts with

 CDK1REACTOME; PUBMED:11959842;

reacts with

 MYBL2REACTOME; PUBMED:11959842;

reacts with

 CDC6REACTOME; PUBMED:17531812;

reacts with

 RBL1REACTOME; PUBMED:17531812;

reacts with

 PCNAREACTOME; PUBMED:17531812;

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