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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 1869 |
Name | E2F1 |
Synonymous | E2F-1|RBAP1|RBBP3|RBP3;E2F transcription factor 1;E2F1;E2F transcription factor 1 |
Definition | PBR3|PRB-binding protein E2F-1|RBAP-1|RBBP-3|retinoblastoma-associated protein 1|retinoblastoma-binding protein 3|transcription factor E2F1 |
Position | 20q11.2 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
E2F-1(h) --> CCND1(h) (DNA binding). | E2F-1(h) --> cycE(h) (DNA binding). | E2F-1(h) --> E2F1(h) (DNA binding). | E2F-1(h) --> B-myb(m) (DNA binding). | E2F-1(h) --> H2A.1(h) (DNA binding). | E2F-1(h) + ATP --cyclinA(h):Cdk2(h)--> E2F-1(h){p} + ADP (phosphorylation) | E2F-1(h) + pRb(h) <==> E2F-1(h):pRb(h) (binding) | E2F-1(h) + ATP --cyclinE(h):Cdk2(h)--> E2F-1(h){p} + ADP (phosphorylation) | E2F-1(h) + DP-1(h) + pRb(h) <==> E2F-1(h):DP-1(h):pRb(h) (binding) | E2F-1(h) + DP-2(h) + pRb(h) <==> E2F-1(h):DP-2(h):pRb(h) (binding) | E2F-1(h) + DP-1(h) <==> E2F-1(h):DP-1(h) (binding) | E2F-1(h) + p53(h) <==> E2F-1(h):p53(h) (binding) | Mdm4-L(m) + E2F-1(h) <==> Mdm4-L(m):E2F-1(h) (binding) | TBP(h) + E2F-1(h) <==> TBP(h):E2F-1(h) (binding). | E2F-2(h) + E2F-1(h) <==> E2F-2(h):E2F-1(h) (binding). | E2F-1(h) + DP-1(m) <==> E2F-1(h):DP-1(m) (binding). | DP-2(h) + E2F-1(h) <==> E2F-1(h):DP-2(h) (binding) | DDB(h) + E2F-1(h) <==> DDB(h):E2F-1(h) (binding). | E2F-1(h) + E2F-1(h) <==> E2F-1(h):E2F-1(h) (binding). | p300(h) + p130(h) + E2F-1(h) <==> p300(h):p130(h):E2F-1(h) (binding) | E2F-1(h) --> RB1(h) (DNA binding). | E2F-1(h) + carm1(h) <==> E2F-1(h):carm1(h) (binding) | E2F-1(h) + ATP --> E2F-1(h){p} + ADP (phosphorylation) | E2F-1(h) --> cyclinD1(h) (increase of abundance) | E2F-1(h) --> TK1(h) (increase of abundance) | E2F-1(h) --> pRb(h) (increase of abundance) | E2F-1(h) + IKK-alpha(h) <==> E2F-1(h):IKK-alpha(h) (binding) | BRD2(m.s.) + E2F-1(h) <==> BRD2(m.s.):E2F-1(h) (binding) | E2F-1(h) + acetyl-CoA --> E2F-1(h){aceK} + CoA (acetylation) | E2F-1(h) + pRb(h) <==> E2F-1(h):pRb(h) (binding) | p/CAF(h) + E2F-1(h) <==> p/CAF(h):E2F-1(h) (binding) | E2F-1(h) --> BCL2(h) (DNA binding; transactivation). | E2F-1(h) --/ TERT(h) (DNA binding; transrepression). | TOP2BP1(h) + E2F-1(h) <==> TOP2BP1(h):E2F-1(h) (binding) | HDAC1(h) + E2F-1(h) + pRb(h) + Dnmt1(h) <==> HDAC1(h):E2F-1(h):pRb(h):Dnmt1(h) (binding) | E2F-1(h) --> TNFSF11(h) (DNA binding). | E2F-1(h) --/ DIRAS3(h) (DNA binding; transrepression). | E2F-1(h) --> GADD45B(h) (DNA binding). | E2F-1(h) --> Nox4(m) (DNA binding). | pawr(h) + E2F-1(h) <==> pawr(h):E2F-1(h) (binding) | pawr(h) + E2F-1(h) <==> pawr(h):E2F-1(h) (binding) | E2F-1(h) + TFIIH-p62(h) <==> E2F-1(h):TFIIH-p62(h) (binding) | E2F-1(h) + TFIIH-p90(h):TFIIH-p62(h):MO15(h) <==> E2F-1(h):TFIIH-p90(h):TFIIH-p62(h):MO15(h) (binding) | E2F-1(h) + trrap(h) <==> E2F-1(h):trrap(h) (binding) | E2F-1(h) + RelA-p65(h) <==> E2F-1(h):RelA-p65(h) (binding) | E2F-1(h) --> DBF4(h) (DNA binding). | E2F-1(h) --> RRP1B(h) (transactivation) | E2F-1(h) --> CASP7(h) (transactivation) | E2F-1(h) --> tk1(h) (transactivation) | rrp1b(h) + E2F-1(h) <==> rrp1b(h):E2F-1(h) (binding) | E2F-1(h) --> AURKB(h) (DNA binding). | E2F-1(h) --> BIK(h) (DNA binding). | E2F1(h) --> E2F-1(h) (expression). | IKK-alpha(h) --> E2F-1(h) (increase of abundance) | pRb(m.s.) --> E2F-1(h) (increase of abundance) | p75NTR(m.s.) --/ E2F-1(h) (decrease of abundance) | IL-2(m.s.) --> E2F-1(h) (increase of abundance) | atad2(h) --> E2F-1(h) (increase of abundance) | E2F-7(h) --/ E2F-1(h) (decrease of abundance) | E2F-8(h) --/ E2F-1(h) (decrease of abundance) | EGF(m.s.) --> E2F-1(h) (increase of abundance) | E2F-1(h) --> RB1(h) (DNA binding). | E2F-1(h) --> tk(HSV1) (DNA binding). | E2F-1(h) --> Pola1(m) (DNA binding). | E2F-1(h) --> cdc25A(h) (DNA binding). | E2F-1(h) --> CYC1(h) (DNA binding). | E2F-1(h) --> SIVA(m) (DNA binding; transactivation). | Sp1(m) + E2F-1(h) <==> Sp1(m):E2F-1(h) (binding) | Sp1(h) + E2F-1(h) <==> Sp1(h):E2F-1(h) (binding) | Sp1(m.s.) + E2F-1(h) <==> Sp1(m.s.):E2F-1(h) (binding) | brca1(h) + E2F-1(h) <==> brca1(h):E2F-1(h) (binding) | JAB1(h) + E2F-1(h) <==> JAB1(h):E2F-1(h) (binding) | MCRS1(h) + E2F-1(h) <==> MCRS1(h):E2F-1(h) (binding) | FHOS(h) + E2F-1(h) <==> FHOS(h):E2F-1(h) (binding) | Filamin(h) + E2F-1(h) <==> Filamin(h):E2F-1(h) (binding) | EIF1(h) + E2F-1(h) <==> EIF1(h):E2F-1(h) (binding) | fabp4(h) + E2F-1(h) <==> fabp4(h):E2F-1(h) (binding) | MX1(h) + E2F-1(h) <==> MX1(h):E2F-1(h) (binding) | HRMT1L3(h) + E2F-1(h) <==> HRMT1L3(h):E2F-1(h) (binding) | E2F-1(h) + RING1B(h) <==> E2F-1(h):RING1B(h) (binding) | RanBPM(h) + E2F-1(h) <==> RanBPM(h):E2F-1(h) (binding) | JAB1(h) + E2F-1(h) <==> JAB1(h):E2F-1(h) (binding) | E2F-1(h) --> p53(r) (increase of abundance) | E2F-1(h) --> Cdkn2a(r) (transactivation) | E2F-1(h) --> Pcna(r) (transactivation) | E2F-1(h) --> PCNA(r) (increase of abundance) | E2F-1(h) + 2 ATP --GSK3beta(m.s.)--> E2F-1(h){pS403}{pT433} + 2 ADP (phosphorylation) | p53-isoform1(h) + E2F-1(h) <==> p53-isoform1(h):E2F-1(h) (binding) | E2F-1(h) + p53-isoform1(h){pS315} <==> E2F-1(h):p53-isoform1(h){pS315} (binding) | Slim-3(h) + E2F-1(h) <==> Slim-3(h):E2F-1(h) (binding) | p/CAF(m.s.) + E2F-1(h) <==> p/CAF(m.s.):E2F-1(h) (binding) | E2F-1(h) + DEDAF(h) <==> E2F-1(h):DEDAF(h) (binding) | E2F-1(h) + 3 acetyl-CoA --> E2F-1(h){aceK117}{aceK120}{aceK125} + 3 CoA (acetylation) | E2F-1(h) + p300(m.s.) <==> E2F-1(h):p300(m.s.) (binding) | E2F-1(h) + acetyl-CoA --CBP(m.s.)--> E2F-1(h){ace} + CoA (acetylation) | E2F-1(h) + acetyl-CoA --p300(m.s.)--> E2F-1(h){ace} + CoA (acetylation) | E2F-1(h) + acetyl-CoA --GCN5(m.s.)--> E2F-1(h){ace} + CoA (acetylation) | E2F-1(h) + 3 acetyl-CoA --p/CAF(h)--> E2F-1(h){aceK117}{aceK120}{aceK125} + 3 CoA (acetylation) | E2F-1(h) + p/CAF(h) <==> E2F-1(h):p/CAF(h) (binding) | E2F-1(h) --/ DIRAS3(h) (transrepression) | E2F-1(h) --> DUSP4(h) (transactivation) | E2F-1(h) --> CDKN2A(h) (transactivation) | E2F-1(h) --> PCSK6(h) (transactivation) | E2F-1(h) --> PTPRO(h) (DNA binding; transactivation). | E2F-1(h) --> MIRN17(h) (DNA binding; transactivation). | E2F-1(h) + ATP --ATM(m.s.)--> E2F-1(h){pS31} + ADP (phosphorylation) | E2F-1(h) + ATP --ATR(m.s.)--> E2F-1(h){pS31} + ADP (phosphorylation) | E2F-1(h) --> E2F-6(h) (transactivation) | E2F-1(h) --> E2F-6(m) (transactivation) | E2F-1(h) + 3 ATP --> E2F-1(h){pS403}{pY411}{pT433} + 3 ADP (phosphorylation) | E2F-1(h) + 3 ATP --TFIIH-p62(h)--> E2F-1(h){pS403}{pY411}{pT433} + 3 ADP (phosphorylation) | E2F-1(h) + MO15(h) <==> E2F-1(h):MO15(h) (binding) | E2F-1(h) --> MAP3K5(h) (DNA binding; transactivation). | E2F-1(h) --> MAP3K5(h) (transactivation) | E2F-1(h) --> ASK1(h) (increase of abundance) | E2F-1(h) --> ASK1(h){p} (increase of phosphorylation) | rrp1b(rb) + E2F-1(h) <==> rrp1b(rb):E2F-1(h) (binding) | E2F-1(h) + rrp1b-isoform1(h) <==> E2F-1(h):rrp1b-isoform1(h) (binding) | E2F1(h) --> E2F-1(h) (expression). | E2F1(h) --> E2F1(h) (expression). | hsa-miR-106a --/ E2F1(h) (predicted) | hsa-miR-106b --/ E2F1(h) (predicted) | hsa-miR-17-5p --/ E2F1(h) (translational repression) | hsa-miR-20a --/ E2F1(h) (predicted) | hsa-miR-20a --/ E2F1(h) (translational repression) | hsa-miR-20b --/ E2F1(h) (predicted) | hsa-miR-330 --/ E2F1(h) (translational repression). |
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Post Transcriptional Modification From dbPTM | | Top | |
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Location (AA) |
PTM type |
Literature |
Database |
375 | Phosphoserine. | Swiss-Prot 53.0 | 403 | Phosphoserine (CDK7) | 10428966 | Phospho.ELM 6.0 | 433 | Phosphothreonine (CDK7) | 10428966 | Phospho.ELM 6.0 | 364 | Phosphoserine (CHK2) | 12717439 | Phospho.ELM 6.0 | 31 | Phosphoserine (ATM;ATR) | 11459832 | Phospho.ELM 6.0 | 332 | Phosphoserine (CDK1) | 8087847 | Phospho.ELM 6.0 | 337 | Phosphoserine (CDK1) | 8087847 | Phospho.ELM 6.0 | 375 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
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Chromosome |
Location |
Source |
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chr20 |
Promoter: 31737354 - 31739354 | Agilent_014791 |
chr20 |
Promoter: 31737354 - 31739354 | GSE27584 |
chr20 |
Promoter: 31737354 - 31739354 | Agilent_014791_44K |
chr20 |
Promoter: 31737354 - 31739354 | Agilent_014791 |