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| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 22943 |
Name | DKK1 |
Synonymous | DKK-1|SK;dickkopf 1 homolog (Xenopus laevis);DKK1;dickkopf 1 homolog (Xenopus laevis) |
Definition | dickkopf related protein-1|dickkopf-1 like|dickkopf-related protein 1|hDkk-1 |
Position | 10q11.2 |
Gene Type | protein-coding |
Gene Interactions: | Physical Interaction Metabolic Interaction Signaling Interaction |
Physical Interaction | | Top | |
|
Interaction Type |
Interactor |
Data Source |
|---|---|---|
interacts with |
MDFI | BIOGRID; PUBMED:16189514; |
interacts with |
LRP6 | BIOGRID; PUBMED:11448771; |
interacts with |
CORO1A | BIOGRID; PUBMED:17353931; |
interacts with |
LRP6 | CELL_MAP; PUBMED:11448771; |
interacts with |
LRP5 | CELL_MAP; PUBMED:11448771; |
interacts with |
MDFI | HPRD; PUBMED:16189514; |
interacts with |
LRP6 | HPRD; PUBMED:11357136; |
interacts with |
LRP5 | HPRD; PUBMED:11516963; |
interacts with |
KREMEN1 | HPRD; PUBMED:12050670; |
interacts with |
SMAD9 | HPRD; PUBMED:15231748; |
interacts with |
MDFI | MINT; PUBMED:16189514; |
interacts with |
SMAD9 | MINT; PUBMED:15231748; |
interacts with |
LRP6 | NCI_NATURE; PUBMED:12050670; |
interacts with |
KREMEN2 | NCI_NATURE; PUBMED:12050670; |
interacts with |
DKK2 | NCI_NATURE; PUBMED:12050670; |
Metabolic Interaction | | Top | |
|
Interaction Type |
Interactor |
Data Source |
|---|---|---|
metabolic catalysis |
MAX | NCI_NATURE; PUBMED:17485441; |
metabolic catalysis |
MED12 | NCI_NATURE; PUBMED:16565090; |
metabolic catalysis |
TCF7L2 | NCI_NATURE; PUBMED:15592430;PUBMED:15592505;PUBMED:15378020; |
metabolic catalysis |
MYC | NCI_NATURE; PUBMED:17485441; |
metabolic catalysis |
HDAC2 | NCI_NATURE; PUBMED:11840333;PUBMED:17409421;PUBMED:10777218; |
metabolic catalysis |
CTNNB1 | NCI_NATURE; PUBMED:15592430;PUBMED:15592505;PUBMED:15378020; |
metabolic catalysis |
CTNNB1 | NCI_NATURE; PUBMED:16565090; |
metabolic catalysis |
TP53 | NCI_NATURE; PUBMED:11840333;PUBMED:17409421;PUBMED:10777218; |
Signaling Interaction | | Top | |
|
Interaction Type |
Interactor |
Data Source |
|---|---|---|
reacts with |
LRP6 | NCI_NATURE; PUBMED:11357136; |
reacts with |
LRP6 | NCI_NATURE; PUBMED:18505732;PUBMED:14731402;PUBMED:20093360;PUBMED:11433302; |
reacts with |
LRP6 | NCI_NATURE; PUBMED:18505822;PUBMED:12527209;PUBMED:11357136;PUBMED:18502762;PUBMED:12050670; |
reacts with |
LRP6 | NCI_NATURE; PUBMED:19477926;PUBMED:11448771;PUBMED:11357136;PUBMED:11029007; |
reacts with |
LRP6 | NCI_NATURE; PUBMED:20053636; |
reacts with |
KREMEN2 | NCI_NATURE; PUBMED:11357136; |
reacts with |
LRP5 | NCI_NATURE; PUBMED:17276019;PUBMED:11336703; |
reacts with |
FZD1 | NCI_NATURE; PUBMED:17276019;PUBMED:11336703; |
reacts with |
FZD8 | NCI_NATURE; PUBMED:18505732;PUBMED:14731402;PUBMED:20093360;PUBMED:11433302; |
reacts with |
FZD8 | NCI_NATURE; PUBMED:19477926;PUBMED:11448771;PUBMED:11357136;PUBMED:11029007; |
reacts with |
DKK2 | NCI_NATURE; PUBMED:11357136; |
reacts with |
DKK1 | NCI_NATURE; PUBMED:11357136; |
reacts with |
DKK1 | NCI_NATURE; PUBMED:17276019;PUBMED:11336703; |
reacts with |
DKK1 | NCI_NATURE; PUBMED:18505732;PUBMED:14731402;PUBMED:20093360;PUBMED:11433302; |
reacts with |
DKK1 | NCI_NATURE; PUBMED:18505822;PUBMED:12527209;PUBMED:11357136;PUBMED:18502762;PUBMED:12050670; |
reacts with |
DKK1 | NCI_NATURE; PUBMED:19477926;PUBMED:11448771;PUBMED:11357136;PUBMED:11029007; |
reacts with |
DKK1 | NCI_NATURE; PUBMED:20053636; |
reacts with |
WNT3A | NCI_NATURE; PUBMED:18505732;PUBMED:14731402;PUBMED:20093360;PUBMED:11433302; |
reacts with |
WNT1 | NCI_NATURE; PUBMED:17276019;PUBMED:11336703; |
reacts with |
WNT1 | NCI_NATURE; PUBMED:19477926;PUBMED:11448771;PUBMED:11357136;PUBMED:11029007; |
state change |
RSPO1 | NCI_NATURE; PUBMED:17804805;PUBMED:20053636;PUBMED:18606139; |