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| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 3486 |
Name | IGFBP3 |
Synonymous | BP-53|IBP3;insulin-like growth factor binding protein 3;IGFBP3;insulin-like growth factor binding protein 3 |
Definition | IBP-3|IGF-binding protein 3|IGFBP-3|acid stable subunit of the 140 K IGF complex|binding protein 29|binding protein 53|growth hormone-dependent binding protein|insulin-like growth factor-binding protein 3 |
Position | 7p13-p12 |
Gene Type | protein-coding |
Gene Interactions: | Physical Interaction Metabolic Interaction Signaling Interaction |
Physical Interaction | | Top | |
|
Interaction Type |
Interactor |
Data Source |
|---|---|---|
interacts with |
GTF3C1 | BIOGRID; PUBMED:16169070; |
interacts with |
CD44 | BIOGRID; PUBMED:12127836; |
interacts with |
Ltbp1 | BIOGRID; PUBMED:12962157; |
interacts with |
FN1 | BIOGRID; PUBMED:11344214; |
interacts with |
FN1 | BIOGRID; PUBMED:12127836; |
interacts with |
POLA2 | BIOGRID; PUBMED:16169070; |
interacts with |
IGF2 | BIOGRID; PUBMED:11600567; |
interacts with |
IGF2 | BIOGRID; PUBMED:11749962; |
interacts with |
IGF2 | BIOGRID; PUBMED:9446566; |
interacts with |
IGF2 | BIOGRID; PUBMED:9497324; |
interacts with |
IGF1R | BIOGRID; PUBMED:9389554; |
interacts with |
ADAM12 | BIOGRID; PUBMED:10849447; |
interacts with |
ADAM12 | BIOGRID; PUBMED:11095942; |
interacts with |
IGFALS | BIOGRID; PUBMED:9446566; |
interacts with |
IGFALS | BIOGRID; PUBMED:9497324; |
interacts with |
IGF1 | BIOGRID; PUBMED:10823924; |
interacts with |
IGF1 | BIOGRID; PUBMED:11600567; |
interacts with |
IGF1 | BIOGRID; PUBMED:12735930; |
interacts with |
IGF1 | BIOGRID; PUBMED:1383255; |
interacts with |
IGF1 | BIOGRID; PUBMED:9446566; |
interacts with |
IGF1 | BIOGRID; PUBMED:9497324; |
interacts with |
PLG | BIOGRID; PUBMED:9688635; |
interacts with |
TF | BIOGRID; PUBMED:11297622; |
interacts with |
Igf2 | BIOGRID; PUBMED:12962157; |
interacts with |
RXRA | BIOGRID; PUBMED:10874028; |
interacts with |
PAPPA2 | BIOGRID; PUBMED:11264294; |
interacts with |
COL1A1 | BIOGRID; PUBMED:12735930; |
interacts with |
MMP3 | HPRD; PUBMED:7523391; |
interacts with |
MMP2 | HPRD; PUBMED:7523391; |
interacts with |
F2 | HPRD; PUBMED:8843739; |
interacts with |
GTF3C1 | HPRD; PUBMED:16169070; |
interacts with |
LTBP1 | HPRD; PUBMED:12962157; |
interacts with |
KLKB1 | HPRD; PUBMED:10226805; |
interacts with |
CD44 | HPRD; PUBMED:12127836; |
interacts with |
CAV1 | HPRD; PUBMED:14576164; |
interacts with |
CTSG | HPRD; PUBMED:10512690; |
interacts with |
GPI | HPRD; PUBMED:15059907; |
interacts with |
POLA2 | HPRD; PUBMED:16169070; |
interacts with |
CSNK2A1 | HPRD; PUBMED:10650937; |
interacts with |
IGF2 | HPRD; PUBMED:10407151; |
interacts with |
IGF1R | HPRD; PUBMED:9389554; |
interacts with |
IGFBP5 | HPRD; PUBMED:12810534; |
interacts with |
MT-RNR2 | HPRD; PUBMED:14561895; |
interacts with |
ADAM12 | HPRD; PUBMED:10849447; |
interacts with |
IGFALS | HPRD; PUBMED:9446566; |
interacts with |
IGFBP2 | HPRD; PUBMED:12810534; |
interacts with |
PLG | HPRD; PUBMED:7538844; |
interacts with |
KPNB1 | HPRD; PUBMED:10811646; |
interacts with |
VTN | HPRD; PUBMED:12810534; |
interacts with |
CTSD | HPRD; PUBMED:9275067; |
interacts with |
CTSL1 | HPRD; PUBMED:11801256; |
interacts with |
COL1A1 | HPRD; PUBMED:12735930; |
interacts with |
GTF3C1 | MINT; PUBMED:16169070; |
interacts with |
POLA2 | MINT; PUBMED:16169070; |
Metabolic Interaction | | Top | |
|
Interaction Type |
Interactor |
Data Source |
|---|---|---|
metabolic catalysis |
TP53 | NCI_NATURE; PUBMED:7566179; |
Signaling Interaction | | Top | |
|
Interaction Type |
Interactor |
Data Source |
|---|---|---|
state change |
F2 | REACTOME; PUBMED:12466191;PUBMED:17047378;PUBMED:12379487;PUBMED:8817670;PUBMED:11739083; |
state change |
KLK3 | REACTOME; PUBMED:10218588;PUBMED:12466191;PUBMED:1383255;PUBMED:17047378;PUBMED:12379487;PUBMED:7538844;PUBMED:11751371;PUBMED:8817670;PUBMED:7525634;PUBMED:7525824; |
state change |
CTSG | REACTOME; PUBMED:10512690; |
reacts with |
IGFBP3 | REACTOME; PUBMED:10218588;PUBMED:12466191;PUBMED:1383255;PUBMED:17047378;PUBMED:12379487;PUBMED:7538844;PUBMED:11751371;PUBMED:8817670;PUBMED:7525634;PUBMED:7525824; |
reacts with |
IGFBP3 | REACTOME; PUBMED:10512690; |
reacts with |
IGFBP3 | REACTOME; PUBMED:10810289;PUBMED:7689487;PUBMED:15485880;PUBMED:9709957;PUBMED:11250653;PUBMED:7519608;PUBMED:2476804;PUBMED:12379487;PUBMED:12810533;PUBMED:8781553;PUBMED:7543116;PUBMED:11316783;PUBMED:10681634;PUBMED:12466191;PUBMED:1370451;PUBMED:15126567;PUBMED:17047378;PUBMED:10026136;PUBMED:9497324;PUBMED:7683646;PUBMED:15469690;PUBMED:11788658; |
reacts with |
IGFBP3 | REACTOME; PUBMED:10990447;PUBMED:12466191;PUBMED:7527330;PUBMED:17047378;PUBMED:8894645;PUBMED:12379487;PUBMED:11739083;PUBMED:8817670;PUBMED:8964575;PUBMED:7588299; |
reacts with |
IGFBP3 | REACTOME; PUBMED:12466191;PUBMED:17047378;PUBMED:12379487;PUBMED:8817670;PUBMED:11739083; |
reacts with |
IGFBP3 | REACTOME; PUBMED:9922210;PUBMED:12466191;PUBMED:7523391;PUBMED:17047378;PUBMED:12379487;PUBMED:8817670; |
state change |
IGFBP3 | REACTOME; PUBMED:10810289;PUBMED:7689487;PUBMED:15485880;PUBMED:9709957;PUBMED:11250653;PUBMED:7519608;PUBMED:2476804;PUBMED:12379487;PUBMED:12810533;PUBMED:8781553;PUBMED:7543116;PUBMED:11316783;PUBMED:10681634;PUBMED:12466191;PUBMED:1370451;PUBMED:15126567;PUBMED:17047378;PUBMED:10026136;PUBMED:9497324;PUBMED:7683646;PUBMED:15469690;PUBMED:11788658; |
reacts with |
IGFALS | REACTOME; PUBMED:10218588;PUBMED:12466191;PUBMED:1383255;PUBMED:17047378;PUBMED:12379487;PUBMED:7538844;PUBMED:11751371;PUBMED:8817670;PUBMED:7525634;PUBMED:7525824; |
reacts with |
IGFALS | REACTOME; PUBMED:10512690; |
reacts with |
IGFALS | REACTOME; PUBMED:10810289;PUBMED:7689487;PUBMED:15485880;PUBMED:9709957;PUBMED:11250653;PUBMED:7519608;PUBMED:2476804;PUBMED:12379487;PUBMED:12810533;PUBMED:8781553;PUBMED:7543116;PUBMED:11316783;PUBMED:10681634;PUBMED:12466191;PUBMED:1370451;PUBMED:15126567;PUBMED:17047378;PUBMED:10026136;PUBMED:9497324;PUBMED:7683646;PUBMED:15469690;PUBMED:11788658; |
reacts with |
IGFALS | REACTOME; PUBMED:10990447;PUBMED:12466191;PUBMED:7527330;PUBMED:17047378;PUBMED:8894645;PUBMED:12379487;PUBMED:11739083;PUBMED:8817670;PUBMED:8964575;PUBMED:7588299; |
reacts with |
IGFALS | REACTOME; PUBMED:12466191;PUBMED:17047378;PUBMED:12379487;PUBMED:8817670;PUBMED:11739083; |
reacts with |
IGFALS | REACTOME; PUBMED:9922210;PUBMED:12466191;PUBMED:7523391;PUBMED:17047378;PUBMED:12379487;PUBMED:8817670; |
state change |
PLG | REACTOME; PUBMED:10990447;PUBMED:12466191;PUBMED:7527330;PUBMED:17047378;PUBMED:8894645;PUBMED:12379487;PUBMED:11739083;PUBMED:8817670;PUBMED:8964575;PUBMED:7588299; |