General information | Expression | Regulation | Mutation | Interaction

Basic Information
Gene ID	9046
Name	DOK2
Synonymous	p56DOK\|p56dok-2;docking protein 2, 56kDa;DOK2;docking protein 2, 56kDa
Definition	docking protein 2\|downstream of tyrosine kinase 2\|p56(dok-2)
Position	8p21.3
Gene Type	protein-coding
Gene Interactions:	Physical Interaction Metabolic Interaction Signaling Interaction

Physical Interaction

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Interaction Type	Interactor	Data Source
interacts with	TEK	BIOGRID; PUBMED:11689432;
interacts with	TEK	BIOGRID; PUBMED:9764820;
interacts with	CFLAR	BIOGRID; PUBMED:17353931;
interacts with	NCK1	BIOGRID; PUBMED:11689432;
interacts with	ASF1B	BIOGRID; PUBMED:17353931;
interacts with	DOK1	BIOGRID; PUBMED:10822173;
interacts with	EGFR	BIOGRID; PUBMED:10508618;
interacts with	HSPA4L	BIOGRID; PUBMED:17353931;
interacts with	DNAJB11	BIOGRID; PUBMED:17353931;
interacts with	KIAA1279	BIOGRID; PUBMED:16189514;
interacts with	RASA1	BIOGRID; PUBMED:10822173;
interacts with	RAB10	BIOGRID; PUBMED:17353931;
interacts with	PSMD10	BIOGRID; PUBMED:17353931;
interacts with	SSSCA1	BIOGRID; PUBMED:17353931;
interacts with	SPOP	BIOGRID; PUBMED:17353931;
interacts with	INPP5D	BIOGRID; PUBMED:10822173;
interacts with	SHC1	BIOGRID; PUBMED:10822173;
interacts with	LYN	HPRD; PUBMED:10428862;
interacts with	NCK1	HPRD; PUBMED:11689432;
interacts with	LCK	HPRD; PUBMED:10799545;
interacts with	EGFR	HPRD; PUBMED:10508618;
interacts with	HCK	HPRD; PUBMED:10428862;
interacts with	IL4R	HPRD; PUBMED:10856136;
interacts with	KIAA1279	HPRD; PUBMED:16189514;
interacts with	RASA1	HPRD; PUBMED:10508618;
interacts with	SRC	HPRD; PUBMED:10428862;
interacts with	INPP5D	HPRD; PUBMED:10822173;
interacts with	PXN	HPRD; PUBMED:12777393;
interacts with	NCK1	MINT; PUBMED:10428862;
interacts with	KIAA1279	MINT; PUBMED:16189514;

Metabolic Interaction

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There is no record for DOK2

Signaling Interaction

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Interaction Type	Interactor	Data Source
state change	TEK	NCI_NATURE; PUBMED:12665569;PUBMED:11689432;PUBMED:9764820;
state change	TEK	NCI_NATURE; PUBMED:9478921;PUBMED:12665569;PUBMED:9764820;
state change	TEK	NCI_NATURE; PUBMED:9764820;
reacts with	NCK1	NCI_NATURE; PUBMED:11689432;PUBMED:16049136;PUBMED:9764820;
reacts with	NCK1	NCI_NATURE; PUBMED:12665569;PUBMED:11689432;PUBMED:9764820;
state change	LCK	NCI_NATURE; PUBMED:9697832;
reacts with	DOK2	NCI_NATURE; PUBMED:11689432;PUBMED:16049136;PUBMED:9764820;
reacts with	DOK2	NCI_NATURE; PUBMED:12665569;PUBMED:11689432;PUBMED:9764820;
reacts with	DOK2	NCI_NATURE; PUBMED:9478921;PUBMED:12665569;PUBMED:9764820;
reacts with	DOK2	NCI_NATURE; PUBMED:9697832;
reacts with	DOK2	NCI_NATURE; PUBMED:9764820;
reacts with	CRK	NCI_NATURE; PUBMED:9764820;
state change	IL2RA	NCI_NATURE; PUBMED:9697832;
state change	IL2RB	NCI_NATURE; PUBMED:9697832;
reacts with	IL4R	NCI_NATURE; PUBMED:9697832;
reacts with	IL2RG	NCI_NATURE; PUBMED:9697832;
state change	IL2RG	NCI_NATURE; PUBMED:9697832;
reacts with	RASA1	NCI_NATURE; PUBMED:9478921;PUBMED:12665569;PUBMED:9764820;
reacts with	RASA1	NCI_NATURE; PUBMED:9697832;
state change	RAC1	NCI_NATURE; PUBMED:11689432;PUBMED:16049136;PUBMED:9764820;
reacts with	JAK1	NCI_NATURE; PUBMED:9697832;
state change	JAK1	NCI_NATURE; PUBMED:9697832;
reacts with	JAK3	NCI_NATURE; PUBMED:9697832;
state change	JAK3	NCI_NATURE; PUBMED:9697832;
state change	ANGPT1	NCI_NATURE; PUBMED:12665569;PUBMED:11689432;PUBMED:9764820;
state change	ANGPT1	NCI_NATURE; PUBMED:9478921;PUBMED:12665569;PUBMED:9764820;
state change	ANGPT1	NCI_NATURE; PUBMED:9764820;
reacts with	IL4	NCI_NATURE; PUBMED:9697832;
state change	IL2	NCI_NATURE; PUBMED:9697832;
reacts with	PAK1	NCI_NATURE; PUBMED:11689432;PUBMED:16049136;PUBMED:9764820;
reacts with	TEK	REACTOME; PUBMED:12665569;PUBMED:11689432;PUBMED:9764820;
reacts with	DOK2	REACTOME; PUBMED:12665569;PUBMED:11689432;PUBMED:9764820;
reacts with	ANGPT1	REACTOME; PUBMED:12665569;PUBMED:11689432;PUBMED:9764820;