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| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 6794 |
Name | STK11 |
Synonymous | LKB1|PJS|hLKB1;serine/threonine kinase 11;STK11;serine/threonine kinase 11 |
Definition | liver kinase B1|polarization-related protein LKB1|renal carcinoma antigen NY-REN-19|serine/threonine-protein kinase 11|serine/threonine-protein kinase LKB1|serine/threonine-protein kinase STK11 |
Position | 19p13.3 |
Gene Type | protein-coding |
Gene Mutation: | Substitution Insertion & Deletion Other Mutation |
Substitution | | Top | |
|
Mutation (Type; AA; Chr) |
Site |
Histology |
|---|---|---|
Substitution - coding silent; c.816C>T; 19:1172293-1172293 |
lung | adenocarcinoma; carcinoma |
Substitution - coding silent; c.816C>T; 19:1172293-1172293 |
lung | adenocarcinoma; carcinoma |
Substitution - coding silent; c.870T>A; 19:1172955-1172955 |
ovary | granulosa_cell_tumour; sex_cord-stromal_tumour |
Substitution - coding silent; c.318G>T; 19:1169443-1169443 |
stomach | intestinal_adenocarcinoma; carcinoma |
Substitution - coding silent; c.816C>T; 19:1172293-1172293 |
lung | adenocarcinoma; carcinoma |
Substitution - coding silent; c.96C>G; 19:1158008-1158008 |
small_intestine | adenocarcinoma; carcinoma |
Substitution - coding silent; c.357C>T; 19:1169482-1169482 |
skin | malignant_melanoma |
Substitution - coding silent; c.96C>G; 19:1158008-1158008 |
cervix | adenoma_malignum |
Substitution - coding silent; c.984C>T; 19:1174047-1174047 |
skin | malignant_melanoma |
Substitution - coding silent; c.1050C>T; 19:1174113-1174113 |
stomach | intestinal_adenocarcinoma; carcinoma |
Substitution - coding silent; c.1257C>T; 19:1177601-1177601 |
pancreas | ductal_carcinoma; carcinoma |
Substitution - coding silent; c.657C>T; |
n; breast | HER-positive_carcinoma; carcinoma |
Indel | | Top | |
|
Mutation (Type; AA; Chr) |
Site |
Histology |
|---|---|---|
Deletion - Frameshift; c.633delG; 19:1171615-1171615 |
lung | non_small_cell_carcinoma; carcinoma |
Deletion - Frameshift; c.827delG; 19:1172304-1172304 |
lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.209delA; 19:1158121-1158121 |
lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.47_651del605; |
lung | squamous_cell_carcinoma; carcinoma |
Deletion - Frameshift; c.709_709delG; 19:1171691-1171691 |
lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.153delG; 19:1158065-1158065 |
lung | large_cell_carcinoma; carcinoma |
Deletion - Frameshift; c.120_130del11; 19:1158032-1158042 |
lung | adenocarcinoma; carcinoma |
Deletion - In frame; c.153_536del384; |
lung | mixed_adenosquamous_carcinoma; carcinoma |
Deletion - In frame; c.291_464del174; |
lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.465_597del133; 19:1171372-1171504 |
lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.180delC; 19:1158092-1158092 |
n; lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.166_178del13; 19:1158078-1158090 |
n; lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.169delG; 19:1158077-1158077 |
lung | non_small_cell_carcinoma; carcinoma |
Deletion - Frameshift; c.650delC; 19:1171632-1171632 |
pancreas | ductal_carcinoma; carcinoma |
Deletion - Frameshift; c.650delC; 19:1171632-1171632 |
pancreas | dysplasia-in_situ_neoplasm; other |
Deletion - Frameshift; c.837delC; 19:1172314-1172314 |
large_intestine; colon; ascending | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.842delC; 19:1172319-1172319 |
lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.143delA; 19:1158055-1158055 |
lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.842delC; 19:1172319-1172319 |
lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.291_378del88; 19:1169416-1169503 |
lung | squamous_cell_carcinoma; carcinoma |
Deletion - Frameshift; c.842delC; 19:1172319-1172319 |
lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.532_536delAAGCC; 19:1171439-1171443 |
prostate | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.837delC; 19:1172314-1172314 |
lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.169delG; 19:1158077-1158077 |
lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.842delC; 19:1172319-1172319 |
large_intestine; colon; sigmoid | adenocarcinoma; carcinoma |
Deletion - In frame; c.291_464del174; |
lung | squamous_cell_carcinoma; carcinoma |
Deletion - Frameshift; c.563delG; 19:1171470-1171470 |
lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.610_623del14; 19:1171592-1171605 |
lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.157delG; 19:1158069-1158069 |
n; lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.607_610delCCGT; 19:1171589-1171592 |
large_intestine; rectum | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.787_790delTTGT; 19:1172264-1172267 |
gastrointestinal_tract_(site_i | hamartoma; other |
Deletion - Frameshift; c.787_790delTTGT; 19:1172264-1172267 |
gastrointestinal_tract_(site_i | hamartoma; other |
Deletion - In frame; c.544_546delCTG; 19:1171451-1171453 |
lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.291_597del307; |
lung | squamous_cell_carcinoma; carcinoma |
Deletion - Frameshift; c.465_597del133; 19:1171372-1171504 |
lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.465_597del133; 19:1171372-1171504 |
lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.735_862del128; 19:1172212-1172339 |
lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.842delC; 19:1172319-1172319 |
lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.1_290del290; 19:1157913-1158202 |
skin; axilla | malignant_melanoma |
Deletion - Frameshift; c.842delC; 19:1172319-1172319 |
lung | adenocarcinoma; carcinoma |
Deletion - In frame; c.126_149del24; 19:1158038-1158061 |
lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.228delC; 19:1158140-1158140 |
lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.579delC; 19:1171486-1171486 |
n; lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.842delC; 19:1172319-1172319 |
skin | malignant_melanoma |
Deletion - Frameshift; c.598delG; 19:1171580-1171580 |
lung | bronchioloalveolar_adenocarcinoma; carcinoma |
Deletion - Frameshift; c.787_790delTTGT; 19:1172264-1172267 |
gastrointestinal_tract_(site_i | hamartoma; other |
Deletion - Frameshift; c.936delA; 19:1173999-1173999 |
pancreas | ductal_carcinoma; carcinoma |
Deletion - Frameshift; c.169delG; 19:1158077-1158077 |
lung | non_small_cell_carcinoma; carcinoma |
Deletion - Frameshift; c.129delC; 19:1158041-1158041 |
lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.180delC; 19:1158092-1158092 |
lung | adenocarcinoma; carcinoma |
Deletion - In frame; c.291_464del174; |
lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.431delC; 19:1170379-1170379 |
n; lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.169delG; 19:1158077-1158077 |
lung | non_small_cell_carcinoma; carcinoma |
Deletion - Frameshift; c.787_790delTTGT; 19:1172264-1172267 |
gastrointestinal_tract_(site_i | hamartoma; other |
Deletion - Frameshift; c.465_597del133; 19:1171372-1171504 |
lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.810delG; 19:1172287-1172287 |
n; lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.180delC; 19:1158092-1158092 |
n; lung | adenocarcinoma; carcinoma |
Deletion - In frame; c.148_159del12; 19:1158060-1158071 |
lung | adenocarcinoma; carcinoma |
Deletion - Frameshift; c.842delC; 19:1172319-1172319 |
lung | squamous_cell_carcinoma; carcinoma |
Other Mutation | | Top | |
|
Mutation (Type; AA; Chr) |
Site |
Histology |
|---|---|---|
Whole gene deletion; c.1_1302del1302; 19:1157913-1177646 |
cervix | squamous_cell_carcinoma; carcinoma |
Complex - frameshift; c.841_842>T; 19:1172318-1172319 |
lung | adenocarcinoma; carcinoma |
Whole gene deletion; c.1_1302del1302; 19:1157913-1177646 |
cervix | squamous_cell_carcinoma; carcinoma |
Whole gene deletion; c.1_1302del1302; 19:1157913-1177646 |
cervix | squamous_cell_carcinoma; carcinoma |
Whole gene deletion; c.1_1302del1302; 19:1157913-1177646 |
cervix | adenocarcinoma; carcinoma |
Whole gene deletion; c.1_1302del1302; 19:1157913-1177646 |
lung | adenocarcinoma; carcinoma |
Whole gene deletion; c.1_1302del1302; 19:1157913-1177646 |
kidney | renal_cell_carcinoma; carcinoma |
Whole gene deletion; c.1_1302del1302; 19:1157913-1177646 |
cervix | adenocarcinoma; carcinoma |
Whole gene deletion; c.1_1302del1302; 19:1157913-1177646 |
oesophagus; middle_third | squamous_cell_carcinoma; carcinoma |
Whole gene deletion; c.1_1302del1302; 19:1157913-1177646 |
ovary | adenocarcinoma; carcinoma |
Whole gene deletion; c.1_1302del1302; 19:1157913-1177646 |
kidney | renal_cell_carcinoma; carcinoma |
Complex - frameshift; c.143_144>T; 19:1158055-1158056 |
lung | non_small_cell_carcinoma; carcinoma |
Whole gene deletion; c.1_1302del1302; 19:1157913-1177646 |
cervix | squamous_cell_carcinoma; carcinoma |
Complex - frameshift; c.75_76CA>T; 19:1157987-1157988 |
lung | adenocarcinoma; carcinoma |
Whole gene deletion; c.1_1302del1302; 19:1157913-1177646 |
cervix | squamous_cell_carcinoma; carcinoma |
Whole gene deletion; c.1_1302del1302; 19:1157913-1177646 |
cervix | adenocarcinoma; carcinoma |
Whole gene deletion; c.1_1302del1302; 19:1157913-1177646 |
cervix | squamous_cell_carcinoma; carcinoma |
Whole gene deletion; c.1_1302del1302; 19:1157913-1177646 |
cervix | squamous_cell_carcinoma; carcinoma |
Whole gene deletion; c.1_1302del1302; 19:1157913-1177646 |
cervix | adenocarcinoma; carcinoma |
Whole gene deletion; c.1_1302del1302; 19:1157913-1177646 |
cervix | squamous_cell_carcinoma; carcinoma |
Complex - frameshift; c.957_958AG>T; 19:1174020-1174021 |
cervix | adenocarcinoma; carcinoma |
Whole gene deletion; c.1_1302del1302; 19:1157913-1177646 |
cervix | squamous_cell_carcinoma; carcinoma |
Whole gene deletion; c.1_1302del1302; 19:1157913-1177646 |
cervix | adenocarcinoma; carcinoma |
Whole gene deletion; c.1_1302del1302; 19:1157913-1177646 |
pancreas | ductal_carcinoma; carcinoma |
Complex - frameshift; c.464_465GG>TTTGCT; |
lung | squamous_cell_carcinoma; carcinoma |