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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 1050 |
Name | CEBPA |
Synonymous | C/EBP-alpha|CEBP;CCAAT/enhancer binding protein (C/EBP), alpha;CEBPA;CCAAT/enhancer binding protein (C/EBP), alpha |
Definition | CCAAT/enhancer-binding protein alpha|c/EBP alpha |
Position | 19q13.1 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
C/EBPalpha(h) --> APOA2(h) (DNA binding). | C/EBPalpha(h) --> factor IX(h) (DNA binding). | C/EBPalpha(h) --> OTC(r) (DNA binding). | C/EBPalpha(h) --> TF(h) (DNA binding). | C/EBPalpha(h) --> apoB(h) (DNA binding). | C/EBPalpha(h) --> SAA1(r) (DNA binding). | C/EBPalpha(h) --> FGA(h) (DNA binding). | C/EBPalpha(h) --> ICAM1(h) (DNA binding). | C/EBPalpha(h) + C/EBPbeta(p35)(m) <==> C/EBPalpha(h):C/EBPbeta(p35)(m) (binding). | C/EBPalpha(h) + C/EBPbeta(LAP)(r) <==> C/EBPalpha(h):C/EBPbeta(LAP)(r) (binding). | C/EBPalpha(h) + C/EBPbeta(h) <==> C/EBPalpha(h):C/EBPbeta(h) (binding). | CHOP-10(m) + C/EBPalpha(h) <==> CHOP-10(m):C/EBPalpha(h) (binding). | C/EBPgamma(m) + C/EBPalpha(h) <==> C/EBPgamma(m):C/EBPalpha(h) (binding). | C/EBPalpha(h) + C/EBPalpha(h) <==> C/EBPalpha(h):C/EBPalpha(h) (binding). | C/EBPalpha(h) + C/EBPdelta(h) <==> C/EBPalpha(h):C/EBPdelta(h) (binding). | C/EBPalpha(h) + C/EBPdelta(m) <==> C/EBPalpha(h):C/EBPdelta(m) (binding). | C/EBPalpha(h) + C/EBPdelta(r) <==> C/EBPalpha(h):C/EBPdelta(r) (binding). | C/EBPalpha(h) + ATF-4(h) <==> C/EBPalpha(h):ATF-4(h) (binding). | C/EBPalpha(h) + NF-AT3(h) <==> NF-AT3(h):C/EBPalpha(h) (assembly; binding; interaction) | NF-AT1(h) + C/EBPalpha(h) <==> NF-AT1(h):C/EBPalpha(h) (binding; assembly; interaction) | C/EBPalpha(h) --> IL10(h) (DNA binding; transactivation). | C/EBPalpha(h) --> SERPINC1(h) (DNA binding). | C/EBPalpha(h) + ATP --ERK(h)--> C/EBPalpha(h){pS21} + ADP (phosphorylation) | C/EBPalpha(h) --> DEFA1(h) (transactivation; DNA binding) | C/EBPalpha(h) --> DEFA3(h) (transactivation; DNA binding) | Cdk2(h) + C/EBPalpha(h) <==> Cdk2(h):C/EBPalpha(h) (binding) | Cdk4(h) + C/EBPalpha(h) <==> Cdk4(h):C/EBPalpha(h) (binding) | AR(h) + C/EBPalpha(h) <==> AR(h):C/EBPalpha(h) (binding) | C/EBPalpha(h) + ASC-2(h) <==> C/EBPalpha(h):ASC-2(h) (binding) | NF-kappaB1-p50(h) + C/EBPalpha(h) <==> NF-kappaB1-p50(h):C/EBPalpha(h) (binding) | 2 C/EBPalpha(h) <==> (C/EBPalpha(h))2 (oligomerization) | NF-IL6-1(h) + C/EBPalpha(h) <==> NF-IL6-1(h):C/EBPalpha(h) (binding) | C/EBPalpha(h) + C/EBPgamma(h) <==> C/EBPalpha(h):C/EBPgamma(h) (binding) | C/EBPalpha(h) + C/EBPdelta(h) <==> C/EBPalpha(h):C/EBPdelta(h) (binding) | C/EBPalpha(h) + CHOP-10(h) <==> C/EBPalpha(h):CHOP-10(h) (binding) | C/EBPalpha(h) + ATF-4(h) <==> C/EBPalpha(h):ATF-4(h) (binding) | C/EBPalpha(h) + ATF5(h) <==> C/EBPalpha(h):ATF5(h) (binding) | C/EBPalpha(h) + ATFa-isoform3(h) <==> C/EBPalpha(h):ATFa-isoform3(h) (binding) | C/EBPalpha(h) + CREBPA-Alpha(h) <==> C/EBPalpha(h):CREBPA-Alpha(h) (binding) | C/EBPalpha(h) + B-ATF(h) <==> C/EBPalpha(h):B-ATF(h) (binding) | batf3(h) + C/EBPalpha(h) <==> batf3(h):C/EBPalpha(h) (binding) | C/EBPalpha(h) + cebpe(h) <==> C/EBPalpha(h):cebpe(h) (binding) | C/EBPalpha(h) --> G6pc(r) (DNA binding). | NF-YA(h) + C/EBPalpha(h) <==> NF-YA(h):C/EBPalpha(h) (binding) | NF-YB(m.s.) + C/EBPalpha(h) <==> NF-YB(m.s.):C/EBPalpha(h) (binding) | C/EBPalpha(h) --> CSF1(h) (DNA binding). | C/EBPalpha(h) --> ALOX5AP(h) (DNA binding; transactivation). | C/EBPalpha(h) --> PTGS2(h) (DNA binding). | C/EBPalpha(h) --> CSF2RA(h) (DNA binding). | C/EBPalpha(h) --> CYP3A4(h) (DNA binding). | C/EBPalpha(h) --> S100A9(h) (DNA binding). | C/EBPalpha(h) --> LTF(h) (DNA binding; transactivation). | C/EBPalpha(h) --> IVL(h) (DNA binding). | C/EBPalpha(h) + c-Jun(h) <==> C/EBPalpha(h):c-Jun(h) (binding) | C/EBPalpha(h) --> SERPINE1(h) (DNA binding). | C/EBPalpha(h) --> CYP19A1(h) (DNA binding). | C/EBPalpha(h) --> CYP2A13(h) (DNA binding). | C/EBPalpha(h) --> TLR9(h) (DNA binding). | C/EBPalpha(h) --> BCL2(h) (transactivation) | C/EBPalpha(h) --> Sfpi1(m) (DNA binding). | C/EBPalpha(h) --> G-CSF(h) (DNA binding). | C/EBPalpha(h) --> STAR(h) (DNA binding; transactivation). | C/EBPalpha(h) --> CES1(h) (DNA binding; transactivation). | C/EBPalpha(h) --> CHI3L1(h) (DNA binding). | C/EBPalpha(h) --> CD14(h) (DNA binding; transactivation). | C/EBPalpha(h) --> GAPDH(h) (DNA binding). | C/EBPalpha(h) --> AHSG(h) (DNA binding). | C/EBPalpha(h) --> CRP(h) (DNA binding). | C/EBPalpha(h) --> PRTN3(h) (DNA binding). | C/EBPalpha(h) --> SLC11A1(h) (DNA binding; transactivation). | CEBPA(h) --> C/EBPalpha(h) (expression). | IL-17A(h) --> C/EBPalpha(h) (increase of abundance) | C/EBPalpha(h) --> Serpina1a(m) (DNA binding). | C/EBPalpha(h) --> CRP(h) (DNA binding). | C/EBPalpha(h) --> HBV enhancer(HBV) (DNA binding; transregulation). | C/EBPalpha(h) --> CETP(h) (DNA binding; transregulation). | C/EBPalpha(h) --> PPARG(h) (DNA binding; transactivation). | C/EBPalpha(h) --/ c-Myc(h) (decrease of abundance) | C/EBPalpha(h) --/ B-Myb(h) (decrease of abundance) | C/EBPalpha(h) --/ Cdk1(h) (decrease of abundance) | C/EBPalpha(h) --/ dihydrofolate reductase(h) (decrease of abundance) | C/EBPalpha(h) + GABP-alpha(h) <==> C/EBPalpha(h):GABP-alpha(h) (binding) | C/EBPalpha(h) --> FCAR(h) (transactivation) | C/EBPalpha(h) --> MIRN223(h) (DNA binding; transactivation) | C/EBPalpha(h) --/ Cdk4(h) (decrease of abundance) | C/EBPalpha(h) --/ cyclinD1(h) (decrease of abundance) | C/EBPalpha(h) --/ cyclinA(h) (decrease of abundance) | C/EBPalpha(h) --> Cdk4(h){ub} (increase of ubiquitination) | AML1(h) + C/EBPalpha(h) <==> AML1(h):C/EBPalpha(h) (binding) | C/EBPalpha(h) + FOXO1A(m) <==> C/EBPalpha(h):FOXO1A(m) (binding) | C/EBPalpha(h) --> ADIPOQ(h) (DNA binding; transactivation). | C/EBPalpha(h) --> Adipoq(m) (DNA binding). | C/EBPalpha(h) --> IGHE(h) (DNA binding; transactivation). | C/EBPalpha(h) --> PRTN3(h) (DNA binding). | CEBPA(h) --> C/EBPalpha(h) (expression). |
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Post Transcriptional Modification From dbPTM | | Top | |
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Location (AA) |
PTM type |
Literature |
Database |
21 | Phosphoserine (MAPK1;MAPK3) | 14701740 | Phospho.ELM 6.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
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Chromosome |
Location |
Source |
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chr19 |
Promoter: 38484660 - 38486660 | Agilent_014791 |
chr19 |
Promoter: 38484660 - 38486660 | GoldenGate_Methylation_Cancer_Panel_I |
chr19 |
Promoter: 38484660 - 38486660 | GSE27584 |
chr19 |
Promoter: 38484660 - 38486660 | PMID:16537832 |