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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 22933 |
Name | SIRT2 |
Synonymous | SIR2|SIR2L|SIR2L2;sirtuin 2;SIRT2;sirtuin 2 |
Definition | NAD-dependent deacetylase sirtuin-2|SIR2-like protein 2|silent information regulator 2|sir2-related protein type 2|sirtuin type 2 |
Position | 19q13 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
SIRT2-isoform1(h) + ATP --> SIRT2-isoform1(h){pS} + ADP (phosphorylation) | SIRT2-isoform1(h) + ATP --Cdk1-isoform1(h):cyclinB1(h)--> SIRT2-isoform1(h){pS368} + ADP (phosphorylation) | SIRT2(h) --> SIRT2-isoform1(h) (expression). | SIRT2(h) + ATP --> SIRT2(h){p} + ADP (phosphorylation) | SIRT2(h) + n ubiquitin(h) --> SIRT2(h){ub}n (ubiquitination) | SIRT2(h) + SERS(h) <==> SIRT2(h):SERS(h) (binding) | SIRT2(h) + prohibitin-2(h) <==> SIRT2(h):prohibitin-2(h) (binding) | SPOP(h) + SIRT2(h) <==> SPOP(h):SIRT2(h) (binding) | SIRT2(h) + gys1(h) <==> SIRT2(h):gys1(h) (binding) | SIRT2(h) + Nogo(h) <==> SIRT2(h):Nogo(h) (binding) | SIRT2(h) + Keratin78(h) <==> SIRT2(h):Keratin78(h) (binding) | ELL(h) + SIRT2(h) <==> ELL(h):SIRT2(h) (binding) | SIRT2(h) --> SIRT2(h) (expression). | SIRT2(h){p} --Cdc14B(h)--> SIRT2(h) + p (dephosphorylation) | SIRT2(h) --> SIRT2-isoform2(h) (expression). |
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Post Transcriptional Modification From dbPTM | | Top | |
There is no record for SIRT2 |
Methylation Profile From DiseaseMeth database | | Top | |
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Chromosome |
Location |
Source |
|---|---|---|
chr19 |
Promoter: 44081701 - 44083701 | GSE27584 |
chr19 |
Promoter: 44081693 - 44083693 | GSE27584 |