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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 2309 |
Name | FOXO3 |
Synonymous | AF6q21|FKHRL1|FKHRL1P2|FOXO2|FOXO3A;forkhead box O3;FOXO3;forkhead box O3 |
Definition | forkhead box O3A|forkhead box protein O3|forkhead homolog (rhabdomyosarcoma) like 1|forkhead in rhabdomyosarcoma-like 1|forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1 |
Position | 6q21 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
FOXO3a(h) + ATP --AKT-1(h)--> FOXO3a(h){pS294}{pS344}{pS425} + ADP (phosphorylation) | FOXO3a(h) --> FASLG(h) (DNA binding). | FOXO3a(h) + 14-3-3zeta(h) <==> FOXO3a(h):14-3-3zeta(h) (binding). | FOXO3a(h) + ATP --SGK-1(r)--> FOXO3a(h){pS294}{pS344}{pS425} + ADP (phosphorylation) | FOXO3a(h) + p300(h) <==> FOXO3a(h):p300(h) (binding) | FOXO3a(h) + 14-3-3beta(h) <==> FOXO3a(h):14-3-3beta(h) (binding) | FOXO3a(h) --> Bcl2l11(r) (transactivation) | FOXO3a(h) --> CAV1(h) (transactivation) | p53(h) + FOXO3a(h) <==> FOXO3a(h):p53(h) (binding) | FOXO3a(h) --> SIRT1(m) (transactivation) | FOXO3a(h) --> BCL6(h) (transactivation) | FOXO3a(h) --> TNFSF10(h) (transactivation) | FOXO3a(h) + SIRT1(h) <==> FOXO3a(h):SIRT1(h) (binding) | FOXO3a(h) + IKK-beta(m.s.) <==> FOXO3a(h):IKK-beta(m.s.) (binding) | FOXO3a(h) --> ESR1(h) (DNA binding; transactivation). | FOXO3a(h) --> PDK4(h) (DNA binding; transactivation). | FOXO3a(h) --> DSIPI(h) (DNA binding). | SIRT1(h) + FOXO3a(h) <==> SIRT1(h):FOXO3a(h) (binding) | FOXO3a(h) + smad4(h) <==> FOXO3a(h):smad4(h) (binding) | FOXO3a(h) + Smads(h) <==> FOXO3a(h):Smads(h) (binding) | FOXO3a(h) --> IRS2(h) (DNA binding; transactivation). | FOXO3a(h) + AML2-isoform1(h) <==> FOXO3a(h):AML2-isoform1(h) (binding) | FOXO3a(h) + 2 ATP --AKT(m.s.)--> FOXO3a(h){pT32}{pS253} + 2 ADP (phosphorylation) | FOXO3a(h) --> TGFB2(h) (DNA binding). | FOXO3a(h) --> FOXO3a(h) (translocation) | FOXO3a(h) + ERK(h) <==> FOXO3a(h):ERK(h) (binding) | FOXO3a(h) + 3 ATP --> FOXO3a(h){pS294}{pS344}{pS425} + 3 ADP (phosphorylation) | FOXO3a(h) + mdm2(h) <==> FOXO3a(h):mdm2(h) (binding) | IKK-beta(h) + FOXO3a(h) <==> IKK-beta(h):FOXO3a(h) (binding) | FOXO3a(h) + IKK-alpha(m.s.) <==> FOXO3a(h):IKK-alpha(m.s.) (binding) | FOXO3a(h) + ATP --IKK-beta(m.s.)--> FOXO3a(h){pS644} + ADP (phosphorylation) | FOXO3a(h) + ATP --> FOXO3a(h){pS644} + ADP (phosphorylation) | FOXO3a(h) + ubiquitin(m.s.) --> FOXO3a(h){ub} (ubiquitination) | FOXO3a(h) + ATP --> FOXO3a(h){pT32} + ADP (phosphorylation) | FOXO3a(h) --> PRDX3(h) (transactivation) | pim1(h) + FOXO3a(h) <==> pim1(h):FOXO3a(h) (binding) | FOXO3a(h) + 2 ATP --> FOXO3a(h){pT32}{pS253} + 2 ADP (phosphorylation) | FOXO3a(h) --> CDKN1B(h) (transactivation) | LXR-beta(h) + FOXO3a(h) <==> LXR-beta(h):FOXO3a(h) (binding) | LXR-alpha(h) + FOXO3a(h) <==> LXR-alpha(h):FOXO3a(h) (binding) | FOXO3a(h) --> NOS2(h) (DNA binding). | FOXO3a(h) --> CDKN1B(h) (DNA binding). | FOXO3a(h) --> ID1(h) (DNA binding). | FOXO3a(h) --> AR(h) (DNA binding). | FOXO3a(h) + ATP --> FOXO3a(h){pS} + ADP (phosphorylation) | FOXO3a(h) --> TNFRSF1B(h) (DNA binding). | FOXO3a(h) --> BCL2L11(h) (DNA binding; transactivation). | FOXO3a(h) --> SOD2(h) (DNA binding). | FOXO3(h) --> FOXO3a(h) (expression). | FOXO3a(h){ace} --SIRT1(h)--> FOXO3a(h) + acetyl (deacetylation) | FOXO3a(h) --> FOXO3a(h) (translocation) | Smad3(m.s.) + FOXO3a(h) <==> Smad3(m.s.):FOXO3a(h) (binding) | Smad4(m.s.) + FOXO3a(h) <==> Smad4(m.s.):FOXO3a(h) (binding) | FOXO3a(h) + 3 ATP --ERK2(h){p}--> FOXO3a(h){pS294}{pS344}{pS425} + 3 ADP (phosphorylation) | FOXO3a(h) --> G6pc(m) (transactivation) | FOXO3a(h) --> NOS2(h) (DNA binding). | FOXO3a(h) --> G6PC(h) (DNA binding). | FOXO3a(h) --> Hmgcs2(r) (DNA binding; transactivation). | FOXO3a(h) --> TNFSF10(h) (DNA binding). | FOXO3a(h) --> Bcl2l11(m) (DNA binding; transactivation). | FOXO3a(h) + 5 ATP --AMPK(m.s.)--> FOXO3a(h){pT179}{pS399}{pS413}{pS555}{pS588}{pS626} + 5 ADP (phosphorylation) | FOXO3a(h) --> NR2C2(h) (DNA binding; transactivation). | FOXO3a(h) + ATP --> FOXO3a(h){pY253} + ADP (phosphorylation) | FOXO3a(h) --> Fbxo32(m) (transactivation) | FOXO3(h) --> FOXO3a(h) (expression). | FOXO3(h) --> FOXO3a-xbb1(h) (expression). |
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Post Transcriptional Modification From dbPTM | | Top | |
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Location (AA) |
PTM type |
Literature |
Database |
32 | Phosphothreonine (by PKB/AKT1). | Swiss-Prot 53.0 | 209 | Phosphoserine (by STK4). | Swiss-Prot 53.0 | 253 | Phosphoserine (by PKB/AKT1). | Swiss-Prot 53.0 | 315 | Phosphoserine (by SGK). | Swiss-Prot 53.0 | 321 | Phosphoserine | 11980723 | Phospho.ELM 6.0 | 318 | Phosphoserine | 11980723 | Phospho.ELM 6.0 | 644 | Phosphoserine (IKK-beta) | 15084260 | Phospho.ELM 6.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
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Chromosome |
Location |
Source |
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chr6 |
Promoter: 108986219 - 108988219 | GSE27584 |
chr6 |
Promoter: 108987262 - 108989262 | GSE27584 |
chr6 |
Promoter: 108987262 - 108989262 | Agilent_014791_44K |
chr6 |
Promoter: 108987262 - 108989262 | Agilent_014791 |
chr6 |
Promoter: 108986219 - 108988219 | Agilent_014791 |